In this lecture, Thomas Weichhart will discuss how studying a mouse model of spontaneous granuloma formation led to the discovery of a key pathogenetic mechanisms in sarcoidosis, a systemic inflammatory disease characterized by granulomas in the lungs, skin, or heart. By dissecting macrophage-driven processes, the lab uncovered metabolic pathways that are active in progressive forms of the disease. These insights guided the development of a targeted treatment strategy, culminating in a successful clinical trial. This translational approach illustrates how basic immunological studies in mice can inform novel, effective therapies for human diseases.
Thomas Weichhart is researcher and Principal Investigator at the Medical University of Vienna, Center for Pathobiochemistry and Genetics.
The BioTechMed-Graz Faculty Club offers a platform for interdisciplinary exchange and networking to all full and associated members of BioTechMed-Graz.
Please register via the BioTechMed-Graz website.
BioTechMed-Graz
18. Juni 2025, 17:00 - 21:00
TU Graz, Campus Neue Technik, Hörsaal BMT Stremayrgasse 16, 8010 Graz
Abhaltungssprache: Englisch
Katrin STÜHLINGER
BioTechMed-Graz
katrin.stuehlinger@uni-graz.at
Tel.: +43 316 3805028