The Redox Biocatalysis Group focuses on the discovery, investigation, and engineering of enzymes instrumental for a sustainable bioeconomy. We are specialised in redox-active metalloenzymes, a diverse group of enzymes that can make and break chemical bonds with high precision. We combine detailed kinetic characterization with AI-driven rational protein design to investigate how Nature overcomes high-energy barriers to perform difficult chemical transformations.
Our current research focuses on the investigation and engineering of enzymes capable of cleaving carbon-halogen bonds with the aim of developing enzymatic routes for the bioremediation of persistent halogenated pollutants.
Second, we study the activation and mechanism of copper-dependent peroxygenases to enhance the oxidative depolymerization of polysaccharides like cellulose and chitin. Beyond their industrial utilisation, we are exploring the emerging roles of these enzymes in biological pathogenicity.

Key Methodologies: Heterologous protein expression, biophysical interaction studies (e.g., MST), steady-state and pre-steady-state kinetics, development of high-throughput activity assays.