Pichler Team

October 2013
October 2013
March 2015
March 2015

Research Goals

We are interested in processes that involve biological membranes. We engineer the membranes of microbes, i.e. bacteria and yeasts, regarding lipid and membrane protein composition, either to understand the complex interactions of these hydrophobic compounds or to apply the modified microorganisms for interesting goals of industrial biotechnology. Our particular focus in the yeast lipid field are sterols, their biosynthesis and homeostasis, and their interactions with membrane proteins.

Pichia pastoris, a methylotrophic yeast, is our favourite host, which we employ for expression and secretion of recombinant soluble proteins as well as for the biosynthesis of valuable metabolites, e.g. plant terpenoids, through heterologous expression of membrane proteins. We have uncovered several endogenous yeast proteins and mechanisms that render protein secretion or membrane protein expression more efficient and sustainable. Based on our expertise in medium to high-throughput screening approaches involving microbes and a background in yeast cell biology, we expand the knowledge on membrane-related processes and extend the molecular toolboxes for applications on industrial scale.

Rational and evolutionary enzyme engineering approaches allow us to make novel enzymes or enzyme families fit for biocatalytic applications, as isolated enzymes or in whole-cell applications. Therefore, we study enzyme characteristics by classical protein analytics and devise novel enzyme assays. We usually team up with structural biologists, biochemists as well as analytical and organic chemists.


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Current Projects

  • January 2014 – ongoing
    ACIB projects 4.5-6 and 24.011 - Engineering hydratases

    We are engineering hydratases for industrial fitness. This project is carried out with company partners at DSM Chemical Technology R&D B.V., Innovative Synthesis (Geleen, The Netherlands).


  • February 2015 – ongoing
    Industrial collaboration project - Terpenoid screening

    We are developing a medium for a high throughput terpenoid screening procedure in collaboration with Isobionics (Geleen, The Netherlands).


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Past Projects

  • September 2005 – June 2009
    Applied Biocatalysis projects 2.11 and P09 - Recombinant esterase for alpha-substituted aliphatic esters – improving the yield

    We have identified a novel isoform of the pig liver esterase protein family, markedly improved expression of pig liver esterases in P. pastoris and E. coli, and have evolutionarily engineered pig liver esterases for biocatalytic applications. This project has been carried out in close collaboration with Prof. Helmut Schwab, Prof. Karl Gruber and company partners at DSM Chemical Technology R&D B.V., Innovative Synthesis (Geleen, The Netherlands) and DPx Fine Chemicals (Linz, Austria).


  • July 2009 – December 2013
    ACIB projects PÜ4.1 and 4.2-1 - Enzyme engineering for complex reactions

    We have generated a promising yeast whole-cell biocatalyst that makes (+)-nootkatone from simple carbon sources. To foster plant terpenoid biosynthesis in yeasts, and to improve the industrial applicability of membrane-attached cytochrome P450 enzymes we have identified several endogenous helper factors in P. pastoris and S. cerevisiae. This project has been carried out in close collaboration with company partners at DSM Chemical Technology R&D B.V., Innovative Synthesis (Geleen, The Netherlands) and DPx Fine Chemicals (Linz, Austria).


  • October 2009 – April 2014
    DK Molecular Enzymology (FWF) PhD project Dr. Christine Winkler - Probing the secretory pathway of the yeast Pichia pastoris

    We have devised a novel, medium-throughput, random mutagenesis/screening protocol for improved protein secretion in P. pastoris. A couple of highly interesting target genes have been identified, partially characterized and filed for patenting. This project has been carried out in close collaboration with Prof. Helmut Schwab.


  • January 2010 – December 2015
    ACIB project 3.2-1 - Pichia pastoris cell factory for protein production

    We have applied multiple approaches to identify key genes that determine protein secretion rates in P. pastoris. Upregulation of several target genes has improved recombinant protein titers and yields. This project has been carried out in close collaboration with Prof. Diethard Mattanovich (Vienna), Prof. Guenther Daum and company partners at Biocrates (Innsbruck, Austria), Biomin (Tulln, Austria), Boehringer Ingelheim-RCV (Vienna, Austria), LONZA (Visp, Switzerland), Sandoz (Kundl, Austria) and VTU (Grambach, Austria).


  • January 2010 – June 2015
    ACIB projects 4.2-2 and 54.041 - Enzyme engineering and substrate channeling for vitamin production

    We have developed and employed screenings for improved production of vitamin precursors. Remarkably, we have managed to engineer a very complex enzyme that has evaded structural elucidation to date. This project was carried out in close collaboration with company partners at DSM Nutritional Products (Kaiseraugst, Switzerland).


  • January 2015 – February 2017
    ACIB project 23.021 - Engineering of protein secretion in Pichia pastoris

    We were following up on several approaches to enhance recombinant protein titers and yields. This project was carried out in close collaboration with Prof. Diethard Mattanovich (Vienna), Prof. Guenther Daum and company partners at Biomin (Tulln, Austria), Boehringer Ingelheim-RCV (Vienna, Austria), LONZA (Visp, Switzerland), Sandoz (Kundl, Austria) and VTU (Grambach, Austria).


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Current Theses

  • PhD Theses

    • Sandra Moser
      Triterpenoid synthesis in yeast

  • Master Theses

    • Chiam Hashem
    • Uchralbayar Tugel
    • Anna Katharina Lämmerer
    • Antonia Volpini de Maestri
    • Andreas Proksch
    • Astrid Radkohl
    • Simon Kobalter

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Completed Theses

  • PhD Theses

    • Dr. Martin Trinker (né Kietzmann)
      January 2009
      Pig liver esterase: Molecular development of a biocatalyst for the industrial production of high-value pharmaceuticals
    • Dr. Veeresh Juturu
      June 2010
      Enhancing the expression of recombinant proteins in the methylotrophic yeast Pichia pastoris
    • Dr. Anita Emmerstorfer
      April 2014
      Improving heterologous cytochrome P450 function in S. cerevisiae
    • Dr. Christine Winkler
      April 2014
      Probing the secretory pathway of the yeast Pichia pastoris
    • Dr. Melanie Hirz
      May 2017
      Tuning of Pichia pastoris for the expression of membrane proteins and small peptides
    • Dr. Matthias Engleder
      July 2018
      Selective hydration of carbon-carbon double bonds: From structure function studies to enzyme engineering

  • Master Theses

    • 2005
      Dr. Veeresh Juturu
    • 2007
      Anja Egger Dr. Michael Tscherner Dr. Eva Hoffmann
    • 2008
      Dr. Andreas Braun Dr. Julia Feichtinger
    • 2009
      Dr. Amin El-Heliebi Dr. Christine Winkler 
    • 2010
      Dr. Andreas Küberl Michael Felber Dr. Anita Emmerstorfer Dr. Birgit Ploier
    • 2011
      Dr. Thomas Vogl Dr. Corinna Odar Dr. Peter Augustin Gerald Richter
    • 2012
      Dr. Melanie Hirz
    • 2013
      Dr. Ariane Fankl Peter Neugebauer
    • 2014
      Katharina Littringer Sandra Moser Miriam Wimmer-Teubenbacher
    • 2015
      Dr. Matthias Engleder Florian Ungerböck Johannes Fuchs
      Sabine Schrempf Bernd Albrecht Mia Potocnjak
    • 2016
      Simon Arhar Stefanie Gabriel Manfred Briendl Elisabeth Hirschböck
    • 2017
      Birgit Grill Christoph Schilling Melissa Horvat Valentin Steinwender Edmund Dittmann Alena Voit Kerstin Stadler Klara Lanz Zan Caf-Feldin Sanja Tunjic
    • 2018
      Johanna Zwick Claudia Gafko Philippe Oberhemm Carolin Kunz Martin Senekowitsch Daniela Brunner Katharina Nagl Johannes Blamauer

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Partners

Scientific partners

  • Prof. Erich Leitner - Institute of Analytical and Food Chemistry, Graz University of Technology, Austria
  • Dr. Gernot Strohmeier - Institute of Organic Chemistry, Graz University of Technology, Austria
  • Prof. Guenther Zellnig - Institute of Plant Physiology, University of Graz, Austria
  • Prof. Harro Bouwmeester - Laboratory of Plant Physiology, University of Wageningen, The Netherlands
  • Prof. Howard Riezman - Department of Biochemistry, University of Geneva, Switzerland
  • Prof. Karl Gruber - Institute of Molecular Biosciences, University of Graz, Austria
  • Prof. Koichi Funato - Department of Biofunctional Science and Technology, Graduate School of Biosphere Science Hiroshima University, Japan
  • Prof. Maria A Vanoni - Department of Biomolecular Sciences and Biotechnology, University of Milano, Italy
  • Dr. Michael Haertlein - Institut Laue-Langevin, Grenoble, France
  • Prof. Steven JD Karlish - Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Industrial collaborations

  • ACIB, Austrian Centre of Industrial Biotechnology (Graz, Vienna, Innsbruck, Austria)
  • DSM Chemical Technology R&D B.V., Innovative Synthesis (Geleen, The Netherlands)
  • DPx Fine Chemicals (Linz, Austria)
  • Biomin (Tulln, Austria)
  • Boehringer Ingelheim RCV (Vienna, Austria) 
  • LONZA (Visp, Switzerland)
  • Sandoz (Kundl, Austria)
  • VTU (Grambach, Austria)

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Selected Publications

2018
JiaJia Dong, Elena Fernández-Fueyo, Frank Hollmann, Caroline Paul, Milja Pasic, Sandy Schmidt, Yonghua Wang, Sabry Younes and Wuyuan Zhang Biocatalytic oxidation reactions - a Chemist's perspective Show publication in PURE
Anita Emmerstorfer-Augustin, Tamara Wriessnegger, Melanie Hirz, Günther Zellnig and Harald Pichler Membrane protein production in yeast: Modification of yeast membranes for human membrane protein productionRecombinant Protein Production in Yeast: Methods and Protocols Show publication in PURE
Matthias Engleder and Harald Pichler On the current role of hydratases in biocatalysis Show publication in PURE
Sandra Moser, Gernot Strohmeier, Erich Leitner, Thomas J Plocek, Koenraad Vanhessche and Harald Pichler Whole-cell (+)-ambrein production in the yeast Pichia pastoris Show publication in PURE
Yan Liu, Rong Gong, Xiaoqin Liu, Peichao Zhang, Qi Zhang, You-Sheng Cai, Zixin Deng, Margit Winkler, Jianguo Wu and Wenqing Chen Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090 Show publication in PURE
Elisa Lanfranchi, Birgit Grill, Zainab Raghoebar, Sander Van Pelt, Roger A Sheldon, Kerstin Steiner, Anton Glieder and Margit Winkler Production of Hydroxynitrile Lyase from Davallia tyermannii (DtHNL) in Komagataella phaffii and Its Immobilization as a CLEA to Generate a Robust Biocatalyst Show publication in PURE
Anna Katharina Migglautsch, Melissa Willim, Bettina Schweda, Anton Glieder, Rolf Breinbauer and Margit Winkler Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X Show publication in PURE
Cyrill Grengg, Florian Mittermayr, Neven Ukrainczyk, Eddie Koenders, Guenther Koraimann, Sabine Kienesberger and Martin Dietzel MICROBIAL INDUCED ACID CORROSION FROM A FIELD PERSPECTIVE – ADVANCES IN PROCESS UNDERSTANDING AND CONSTRUCTION MATERIAL DEVELOPMENTProceedings of final conference of RILEM TC 253-MCI3-10 Show publication in PURE
Alessandra Luchini, Robin Delhom, Bruno Demé, Valérie Laux, Martine Mouline, Michael Haertlein, Harald Pichler, Gernot Strohmeier, Hanna Wacklin and Giovanna Fragneto The Impact of Deuteration on Natural and Synthetic Lipids: a Neutron Diffraction Study Show publication in PURE
Harald Pichler and Anita Emmerstorfer-Augustin Modification of Membrane Lipid Compositions in single-celled organisms–from Basics to Applications Show publication in PURE
Holly Stolterfoht, Georg Steinkellner, Daniel Schwendenwein, Tea Pavkov-Keller, Karl Gruber and Margit Winkler Identification of key residues for enzymatic carboxylate reduction Show publication in PURE
Robert Kourist, Anna Schweiger and Hanna Büchsenschütz Enzymatic Decarboxylation as a Tool for the Enzymatic Defunctionalization of Hydrophobic Bio-based Organic AcidsLipid Modification by Enzymes and Engineered Microbes89-118 Show publication in PURE
Martine Mouline, Gernot Strohmeier, Melanie Hirz, Katherine Thompson, Adrian Rennie, Richard A Campbell, Harald Pichler, Selma Maric, Trevor Forsyth and Michael Haertlein Perdeuteration of cholesterol for neutron scattering applicatioins using recombinant Pichia pastoris Show publication in PURE
Matthias Engleder, Melissa Horvat, Anita Emmerstorfer-Augustin, Tamara Wriessnegger, Stefanie Gabriel, Gernot Strohmeier, Hansjörg Weber, Monika Müller, Iwona Kaluzna, Daniel Mink, Martin Schürmann and Harald Pichler Recombinant expression, purification and biochemical characterization of kievitone hydratase from Nectria haematococca Show publication in PURE
Thomas Kickenweiz, Anton Glieder and Jin Chuan Wu Construction of a cellulose-metabolizing Komagataella phaffii (Pichia pastoris) by co-expressing glucanases and β-glucosidase Show publication in PURE
Sandy Schmidt, Mark Dörr and Uwe T. Bornscheuer Library growth and protein expressionMethods in Molecular Biology145-156 Show publication in PURE
Samiro Bojarra, Dennis Reichert, Marius Grote, Álvaro Gómez Baraibar, Alexander Dennig, Bernd Nidetzky, Carolin Mügge and Robert Kourist Bio-based α,ω functionalized hydrocarbons from multi-step reaction sequences with bio- and metallo-catalysts based on the fatty acid decarboxylase OleTJE Show publication in PURE
2017
Sandy Schmidt, Harald Gröger and Robert Kourist Durch Trennen verbinden Show publication in PURE
Anna Reimer, Severin Wedde, Svenja Staudt, Sandy Schmidt, Diana Höffer, Werner Hummel, Udo Kragl, Uwe T. Bornscheuer and Harald Gröger Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical ε-Caprolactone Show publication in PURE
Sandy Schmidt, Tiago Pedroso de Almeida, Dörte Rother and Frank Hollmann Towards environmentally acceptable synthesis of chiral alpha-hydroxy ketones via oxidase-lyase cascades Show publication in PURE
Marine Rauch, Sandy Schmidt, Isabel W. C. E. Arends, Kerstin Oppelt, Selin Kara and Frank Hollmann Photobiocatalytic alcohol oxidation using LED light sources Show publication in PURE
Severin Wedde, Philipp Rommelmann, Christian Scherkus, Sandy Schmidt, Uwe T. Bornscheuer, Andreas Liese and Harald Gröger An alternative approach towards poly-epsilon-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates Show publication in PURE
Stefanie Böhmer, Katharina Köninger, Alvaro Gomez-Baraibar, Samiro Bojarra, Carolin Mügge, Sandy Schmidt, Marc Nowaczyk and Robert Kourist Enzymatic Oxyfunctionalization Driven by Photosynthetic Water-Splitting in the Cyanobacterium Synechocystis sp. PCC 6803 Show publication in PURE
Sandy Schmidt, Kathrin Castiglione and Robert Kourist Overcoming the incompatibility challenge in chemo-enzymatic and multi-catalytic cascade reactions. Show publication in PURE
Thomas Bayer, Thomas Wiesinger, Sofia Milker, Margit Winkler, Marko D. Mihovilovic and Florian Rudroff IN VIVO SYNTHESIS OF POLYHYDROXYLATED COMPOUNDS FROM A ‘HIDDEN RESERVOIR’ OF TOXIC ALDEHYDE SPECIES Show publication in PURE
Elisa Lanfranchi, Tea Pavkov-Keller, Eva-Maria Koehler, Matthias Diepold, Kerstin Steiner, Barbara Darnhofer, Jürgen Hartler, Tom Van Den Bergh, Henk-Jan Joosten, Mandana Gruber-Khadjawi, Gerhard G Thallinger, Ruth Birner-Gruenberger, Karl Gruber, Margit Winkler and Anton Glieder Enzyme discovery beyond homology Show publication in PURE
Vicente Planells-Palop, Ali Hazazi, Julia Feichtinger, Jana Jezkova, Gerhard Thallinger, Naif O Alsiwiehri, Mikhlid Almutairi, Lee Parry, Jane A Wakeman and Ramsay J McFarlane Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis Show publication in PURE
Tea Pavkov-Keller, Kerstin Steiner, Mario Faber, Martin Tengg, Helmut Schwab, Mandana Gruber-Khadjawi and Karl Gruber Crystal Structure and Catalytic Mechanism of CouO, a Versatile C-Methyltransferase from Streptomyces rishiriensis Show publication in PURE
Alexander J A Deutsch, Beate Rinner, Martin Pichler, Katharina Prochazka, Katrin Pansy, Marco Bischof, Karoline Fechter, Stefan Hatzl, Julia Feichtinger, Kerstin Wenzl, Marie-Therese Frisch, Verena Stiegelbauer, Andreas Prokesch, Anne Krogsdam, Heinz Sill, Gerhard G Thallinger, Hildegard T Greinix, Chenguang Wang, Christine Beham-Schmid and Peter Neumeister NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes Show publication in PURE
Holly Stolterfoht, Daniel Schwendenwein, Christoph Wilhelm Sensen, Florian Rudroff and Margit Winkler Four distinct types of E.C. 1.2.1.30 enzymes can catalyze the reduction of carboxylic acids to aldehydes Show publication in PURE
Uwe T. Bornscheuer and Robert Kourist Evolving Enzymes for BiocatalysisConsequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals1-17 Show publication in PURE
F. Geigl, C. Moik, Stefan Hinteregger and M. Goller Using Machine Learning and RFID Localization for Advanced Logistic Applications2017 IEEE Int. Conf. RFID73-74 Show publication in PURE
Octavia N. Kracht, Ann-Christin Ammann, Julia Stockmann, D Wibberg, J Kalinowski, M Piotrowski, R Kerr, T. B. Brück and R. Kourist Transcriptome Profiling of the Australian arid-land Plant Eremophila serrulata for the Identification of Monoterpene synthases Show publication in PURE
Sarah Waldie, Tania K Lind, Kathryn Browning, Martine Mouline, Michael Haertlein, Trevor Forsyth, Alessandra Luchini, Gernot Strohmeier, Harald Pichler, Selma Maric and Marité Cárdenas Localization of Cholesterol within Supported Lipid Bilayers Made of a Natural Extract of Tailor-Deuterated Phosphatidylcholine Show publication in PURE
Elisa Lanfranchi, Tea Pavkov-Keller, Eva-Maria Koehler, Matthias Diepold, Kerstin Steiner, Barbara Darnhofer, Jürgen Hartler, Tom Van Den Bergh, Henk-Jan Joosten, Mandana Gruber-Khadjawi, Gerhard G Thallinger, Ruth Birner-Gruenberger, Karl Gruber, Margit Winkler and Anton Glieder Erratum Show publication in PURE
Peter Ulz, Michael R. Speicher and Gerhard Thallinger Reconstruction of mitochondrial genotypes from diverse next generation sequencing datasetsProceedings of the 10th International joint conference on Biomedical Engineering Systems and Technologiesin press Show publication in PURE
Rui M C Portela, Thomas Vogl, Claudia Kniely, Jasmin E Fischer, Rui Oliveira and Anton Glieder Synthetic Core Promoters as Universal Parts for Fine-Tuning Expression in Different Yeast Species Show publication in PURE
Kristína Markošová, Andrea Camattari, Michal Rosenberg, Anton Glieder, Nicholas J Turner and Martin Rebroš Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris Show publication in PURE
Astrid Weninger, Jasmin Fischer, Hana Raschmanová, Claudia Kniely, Thomas Vogl and Anton Glieder Expanding the CRISPR/Cas9 toolkit for Pichia pastoris with efficient donor integration and alternative resistance markers Show publication in PURE
Rui M C Portela, Thomas Vogl, Katharina Ebner, Rui Oliveira and Anton Glieder Pichia pastoris Alcohol Oxidase 1 (AOX1) Core Promoter Engineering by High Resolution Systematic Mutagenesis Show publication in PURE
Robert Kourist and Uwe T. Bornscheuer BiocatalysisApplied Homogeneous Catalysis with Organometallic Compounds Show publication in PURE
Robert Kourist and Carolin Mügge Practical Considerions Regarding the Choice of High-Throughput-AssaysProtein Engineering- Methods and Protocols189-208 Show publication in PURE
2016
Margit Winkler and Christoph K. Winkler TRAMETES VERSICOLOR CARBOXYLATE REDUCTASE UNCOVERED Show publication in TUGRAZonline
Filippo Fiorentini, Martina Geier, Claudia Binda, Margit Winkler, Kurt Faber, Mélanie Hall and Andrea Matteiv Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans Show publication in TUGRAZonline
Jürgen Hartler LipidHomeEncyclopedia of Lipidomicsn/a - n/a Show publication in TUGRAZonline
Jürgen Hartler MassBankEncyclopedia of Lipidomicsn/a - n/a Show publication in TUGRAZonline
Jürgen Hartler LIPID MAPS: Tools and DatabasesEncyclopedia of Lipidomicsn/a - n/a Show publication in TUGRAZonline
Anita Emmerstorfer and Harald Pichler Production of aromatic plant terpenoids in recombinant baker´s yeastBiotechnology of Plant Secondary Metabolism79 - 89 Show publication in TUGRAZonline
Ryan C Smith, Jonas G King, Dingyin Tao, Oana A Zeleznik, Clara Brando, Gerhard G Thallinger and Rhoel R Dinglasan Molecular profiling of phagocytic immune cells in Anopheles gambiae reveals integral roles for hemocytes in mosquito innate immunity Show publication in PURE
Harald Pichler Oleate hydratase - structure function relationships and applicationPower of microbes in industry and environment33 Show publication in PURE
Daniel Schwendenwein, Giuseppe Fiume, Hansjörg Weber, Florian Rudroff and Margit Winkler Selective Enzymatic Transformation to Aldehydes in vivo by Fungal Carboxylate Reductase from Neurospora crassa Show publication in PURE
Katrin Weinhandl, Melanie Ballach, Margit Winkler, Ahmad Mudassar, Anton Glieder, Ruth Birner-Gruenberger, Ian Fotheringham and Franck Escalettes Pichia pastoris mutants as host strains for efficient secretion of recombinant Branched Chain Aminotransferase (BCAT) Show publication in PURE
Martial Rey, Menglin Yang, Linda Lee, Ye Zhang, Joey G Sheff, Christoph W Sensen, Hynek Mrazek, Petr Halada, Petr Man, Justin L McCarville, Elena F Verdu and David C Schriemer Addressing proteolytic efficiency in enzymatic degradation therapy for celiac disease Show publication in PURE
Linda Lee, Ye Zhang, Brittany Ozar, Christoph W Sensen and David C Schriemer Carnivorous Nutrition in Pitcher Plants (Nepenthes spp.) via an Unusual Complement of Endogenous Enzymes Show publication in PURE
Bernd Nidetzky and Christoph W Sensen Special Issue on acib, Dedicated to the Occasion of Prof. Dr. Helmut Schwab's 65th Birthday Show publication in PURE
Veronika Perz, Altijana Hromic, Georg Steinkellner, Tea Pavkov-Keller, Karl Gruber, Klaus Bleymaier, Sabine Zitzenbacher, Armin Zankel, Claudia Mayrhofer, Carsten Sinkel, Ulf Kueper, Katharina Schlegel, Doris Ribitsch and Georg M. Guebitz An Esterase from Anaerobic Clostridium hathewayi Can Hydrolyze Aliphatic−Aromatic Polyesters Show publication in PURE
S L Wilson, C Li, E Ramos-Padrón, C Nesbø, J Soh, C W Sensen, G Voordouw, J Foght and L M Gieg Oil sands tailings ponds harbour a small core prokaryotic microbiome and diverse accessory communities Show publication in PURE
Christian Scherkus, Sandy Schmidt, Uwe T. Bornscheuer, Harald Gröger, Selin Kara and Andreas Liese A Fed-Batch Synthetic Strategy for a Three-Step Enzymatic Synthesis of Poly-ϵ-caprolactone Show publication in PURE
Patrick Hyden, Ariane Pietzka, Anna Lennkh, Andrea Murer, Burkhard Springer, Marion Blaschitz, Alexander Indra, Steliana Huhulescu, Franz Allerberger, Werner Ruppitsch and Christoph W Sensen Whole genome sequence-based serogrouping of Listeria monocytogenes isolates Show publication in PURE
Bastian Daniel, Silvia Wallner, Barbara Steiner, Gustav Oberdorfer, Prashant Kumar, Eric van der Graaff, Thomas Roitsch, Christoph W Sensen, Karl Gruber and Peter Macheroux Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae Show publication in PURE
Anita Emmerstorfer, Sandra Moser and Harald Pichler Screening for improved isoprenoid biosynthesis in microorganisms Show publication in PURE
Marcia Ferreira Antunes, Fabian K. Eggimann, Matthias Kittelmann, Stephan Lütz, Steven P. Hanlon, Beat Wirz, Thorsten Bachler and Margit Winkler Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis Show publication in PURE
Tamara Wriessnegger, Sandra Moser, Anita Emmerstorfer-Augustin, Erich Leitner, Monika Müller, Iwona Kaluzna, Martin Schürmann, Mink Daniel and Harald Pichler Enhancing cytochrome P450-mediated conversions in P. pastoris through RAD52 over-expression and optimizing the cultivation conditions Show publication in PURE
Zalina Magomedova, Andreea Grecu, Christoph W Sensen, Helmut Schwab and Petra Heidinger Characterization of two novel alcohol short-chain dehydrogenases/reductases from Ralstonia eutropha H16 capable of stereoselective conversion of bulky substrates Show publication in PURE
Patrick Hyden, Ariane Pietzka, Franz Allerberger, Burkhard Springer, Christoph Sensen and Werner Ruppitsch Draft Genome Sequence of a 94-Year-Old Listeria monocytogenes Isolate, SLCC208 Show publication in PURE
Margit Winkler and Christoph K. Winkler TRAMETES VERSICOLOR CARBOXYLATE REDUCTASE UNCOVERED Show publication in PURE
Anita Emmerstorfer and Harald Pichler Production of aromatic plant terpenoids in recombinant baker´s yeastBiotechnology of Plant Secondary Metabolism79-89 Show publication in PURE
Tea Pavkov-Keller, Gernot Strohmeier, Matthias Diepold, Wilco Peeters, Natascha Smeets, Martin Schürmann, Karl Gruber, Helmut Schwab and Kerstin Steiner Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold Show publication in PURE
Marc Nowaczyk and Robert Kourist Lichtgetriebene Ganzzellbiotransformation mit rekombinanten Cyanobakterien Show publication in PURE
F Busch, N. Hülsemann, J Enoki, K Miyamoto, M Bocola and R Kourist Semiempirical QM/MM calculations reveal a step-wise proton transfer and an unusual thiolate pocket in the mechanism of the racemizing mutant G74C of arylmalonate decarboxylase Show publication in PURE
S. K. Gaßmeyer, J Wetzig, C Mügge, M Assmann, J Enoki, L Hilterhaus, R Zuhse, K Miyamoto, A Liese and R Kourist Arylmalonate decarboxylase-catalyzed asymmetric synthesis of both enantiomers of optically pure flurbiprofen Show publication in PURE
Katrin Niegelhell, Michael Süßenbacher, Thomas Ganner, Daniel Schwendenwein, Helmut Schwab, Franz Stelzer, Harald Plank and Stefan. Spirk Enzymes as Biodevelopers for Nano- And Micropatterned Bicomponent Biopolymer Thin Films. Show publication in PURE
Florian Krainer, Barbara Darnhofer, Ruth Birner-Gruenberger and Anton Glieder Recombinant production of a peroxidase-protein G fusion protein in Pichia pastoris Show publication in PURE
Lukas Sturmberger, Paal W Wallace, Anton Glieder and Ruth Birner-Gruenberger Synergism of proteomics and mRNA sequencing for enzyme discovery Show publication in PURE
Astrid Weninger, Anna-Maria Hatzl, Christian Schmid, Thomas Vogl and Anton Glieder Combinatorial optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris Show publication in PURE
Florian W. Krainer, Michaela A. Gerstmann, Barbara Darnhofer, Ruth Birner-Gruenberger and Anton Glieder Biotechnological advances towards an enhanced peroxidase production in Pichia pastoris Show publication in PURE
Martin Tengg, Harald Stecher, Lisa Offner, Katharina Plasch, Felix Anderl, Hansjörg Weber, Helmut Schwab and Mandana Gruber Methyltransferases Show publication in PURE
Thomas Vogl, Lukas Sturmberger, Thomas Kickenweiz, Richard Wasmayer, Christian Schmid, Anna-Maria Hatzl, Michaela Agnes Gerstmann, Julia Pitzer, Marlies Wagner, Gerhard G Thallinger, Martina Geier and Anton Glieder A Toolbox of Diverse Promoters Related to Methanol Utilization Show publication in PURE
Chen Meng, Oana Alina Zeleznik, Gerhard G Thallinger, Bernhard Küster, Amin M Gholami and Aedín C Culhane Dimension reduction techniques for the integrative analysis of multi-omics data Show publication in PURE
Julia Feichtinger, Inmaculada Hernández, Christoph Fischer, Michael Hanscho, Norbert Auer, Matthias Hackl, Vaibhav Jadhav, Martina Baumann, Peter M Krempl, Christian Schmidl, Matthias Farlik, Michael Schuster, Angelika Merkel, Andreas Sommer, Simon Heath, Daniel Rico, Christoph Bock, Gerhard G Thallinger and Nicole Borth Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time Show publication in PURE
Natalia Gomez-Escobar, Nasser Almobadel, Othman Alzahrani, Julia Feichtinger, Vicente Planells-Palop, Zafer Alshehri, Gerhard G Thallinger, Jane A Wakeman and Ramsay J McFarlane Translin and Trax differentially regulate telomere-associated transcript homeostasis Show publication in PURE
Filippo Fiorentini, Martina Geier, Claudia Binda, Margit Winkler, Kurt Faber, Mélanie Hall and Andrea Matteiv Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans Show publication in PURE
Robert Krause, Bettina Halwachs, Gerhard Thallinger, Ingeborg Klymiuk, Gregor Gorkiewicz, Martin Hoenigl, Jürgen Prattes, Thomas Valentin, Katharina Heidrich, Walter Buzina, Helmut J F Salzer, Jasmin Rabensteiner, Florian Prüller, Reinhard B Raggam, Andreas Meinitzer, Christine Moissl-Eichinger, Christoph Högenauer, Franz Quehenberger, Karl Kashofer and Ines Zollner-Schwetz Characterisation of Candida within the Mycobiome/Microbiome of the Lower Respiratory Tract of ICU Patients Show publication in PURE
Minoska Valli, Nadine E Tatto, Armin Peymann, Clemens Gruber, Nils Landes, Heinz Ekker, Gerhard G Thallinger, Diethard Mattanovich, Brigitte Gasser and Alexandra B Graf Curation of the genome annotation of Pichia pastoris (Komagataella phaffii) CBS7435 from gene level to protein function Show publication in PURE
Peter Ulz, Gerhard G Thallinger, Martina Auer, Ricarda Graf, Karl Kashofer, Stephan W Jahn, Luca Abete, Gunda Pristauz, Edgar Petru, Jochen B Geigl, Ellen Heitzer and Michael R Speicher Inferring expressed genes by whole-genome sequencing of plasma DNA Show publication in PURE
2015
Margit Winkler Drug Metabolite Synthesis with Human Enzymes Show publication in TUGRAZonline
Ivan Hajnal, Kurt Faber, Helmut Schwab, Melanie Hall and Kerstin Steiner Oxidative Alkene Cleavage Catalysed by Manganese-​Dependent Cupin TM1459 from Thermotoga maritima Show publication in TUGRAZonline
Thomas Vogl, Mudassar Ahmad, Florian Krainer, Helmut Schwab and Anton Glieder Restriction site free cloning (RSFC) plasmid family for seamless, sequence independent cloning in Pichia pastoris Show publication in TUGRAZonline
Jillian M. Hagel, Jeremy S. Morris, Eun-Jeong Lee, Isabel Desgagne-Penix, Crystal D. Bross, Limei Chang, Xue Chen, Scott C. Farrow, Ye Zhang, Jung Soh, Christoph Wilhelm Sensen and Peter J. Facchini Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. Show publication in TUGRAZonline
Margit Winkler, Katharina Dokulil, Hansjörg Weber, Tea Pavkov-Keller and Birgit Wilding The Nitrile forming Enzyme 7-Cyano-7-deazaguanine Synthase from Geobacillus kaustophilus: A reverse Nitrilase? Show publication in TUGRAZonline
Thomas Eichmann, Lukas Grumet, Ulrike Taschler, Jürgen Hartler, Christoph Heier, Aaron Woblistin, Laura Pajed, Manfred Kollroser, Gerald Rechberger, Gerhard Thallinger, Rudolf Zechner, Guenter Haemmerle, Robert Zimmermann and Achim Lass ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6 Show publication in TUGRAZonline
Man-Ling Wong, Dongshan An, Sean Caffrey, Jung Soh, Xiaoli Dong, Christoph Wilhelm Sensen, Thomas Oldenburg, Stephen R. Larter and Gerrit Voordouw Roles of Thermophiles and Fungi in Bitumen Degradation in Mostly Cold Oil Sands Outcrops Show publication in TUGRAZonline
Petra Köfinger, Steffen Gruber and Helmut Schwab Versatile plasmid-based expression systems for Gram-negative bacteria-General essentials exemplified with the bacterium Ralstonia eutropha H16. Show publication in TUGRAZonline
Bastian Daniel, Tea Pavkov-Keller, Barbara Steiner, Angela Dodic, Alexander Gutmann, Bernd Nidetzky, Christoph Wilhelm Sensen, Eric van der Graaff, Silvia Wallner, Karl Gruber and Peter Macheroux Oxidation of monolignols by members of the berberine bridge enzyme family suggests a role in plant cell wall metabolism Show publication in TUGRAZonline
Matthias Engleder, Tea Pavkov-Keller, Anita Emmerstorfer, Hromic Altijana, Sabine Schrempf, Georg Steinkellner, Tamara Wriessnegger, Erich Leitner, Gernot Strohmeier, Iwona Kaluzna, Mink Daniel, Schürmann Martin, Silvia Wallner, Peter Macheroux, Karl Gruber and Harald Pichler Structure-based mechanism of oleate hydratase from Elizabethkingia meningoseptica Show publication in TUGRAZonline
Martina Geier, Thorsten Bachler, Steven P Hanlon, Fabian K Eggimann, Matthias Kittelmann, Hansjörg Weber, Stephan Lütz, Beat Wirz and Margit Winkler Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis Show publication in TUGRAZonline
Elisa Lanfranchi, Eva-Maria Köhler, Barbara Darnhofer, Kerstin Steiner, Ruth Birner-Grünberger, Anton Glieder and Margit Winkler Bioprospecting for Hydroxynitrile Lyases by Blue Native PAGE Coupled HCN Detection Show publication in TUGRAZonline
Atsuko Ikeda, Tetsuya Muneoka, Suguru Murakami, Ayaka Hirota, Yukari Yabuki , Takefumi Karashima, Kota Nakazono, Masahiro Tsuruno, Harald Pichler, Katsuhiko Shirahige, Yukiko Kodama, Toshi Shimamoto, Keiko Mizuta and Kouichi Funato Sphingolipids regulate telomere clustering by affecting transcriptional levels of genes involved in telomere homeostasis Show publication in TUGRAZonline
UM Tran, U. Rajarajacholan , Jung Soh, TS Kim, S. Thalappilly , Christoph Wilhelm Sensen and Karl Riabowol LincRNA-p21 acts as a mediator of ING1b-induced apoptosis Show publication in TUGRAZonline
B. Tan, Jane Fowler, N.A. Laban, Xiaoli Dong, Christoph Wilhelm Sensen, Julia Foght and Lisa M. Gieg Comparative analysis of metagenomes from three methanogenic hydrocarbon-degrading enrichment cultures with 41 environmental samples. Show publication in TUGRAZonline
Ryan A. Groves, Jillian M. Hagel, Ye Zhang, Kilpatrick Korey, Levy Asaf, Marsolais Frederic, Lewinsohn Efraim, Christoph Wilhelm Sensen and Facchini Peter J. Transcriptome Profiling of Khat (Catha edulis) and Ephedra sinica Reveals Gene Candidates Potentially Involved in Amphetamine-Type Alkaloid Biosynthesis. Show publication in TUGRAZonline
Armin Erlacher, Tomislav Cernava, Massimiliano Cardinale, Jung Soh, Christoph Wilhelm Sensen, Martin Grube and Gabriele Berg Rhizobiales as functional and endosymbiontic members in the lichen symbiosis Lobaria pulmonaria L.. Show publication in TUGRAZonline
Corinna Odar, Margit Winkler and Birgit Wiltschi FLUORINATED AMINO ACIDS – A RARITY IN NATURE YET A PROSPECT FOR PROTEIN ENGINEERING Show publication in TUGRAZonline
Martina Geier, Pia Carina Fauland, Thomas Vogl and Anton Glieder Compact multi-enzyme pathways in P. pastoris Show publication in TUGRAZonline
Florian Krainer and Anton Glieder An updated view on horseradish peroxidases: recombinant production and biotechnological applications. Show publication in TUGRAZonline
Florian Krainer, Simona Capone, Martin Jäger, Thomas Vogl, Michaela Agnes Gerstmann, Anton Glieder, Christoph Herwig and Oliver Spadiut Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris. Show publication in TUGRAZonline
Katharina Schmoelzer, Tibor Czabany, Christiane Luley, Tea Pavkov-Keller, Doris Ribitsch, Helmut Schwab, Karl Gruber, Hansjörg Weber and Bernd Nidetzky Complete switch from α-2,3- to α-2,6-regioselectivity in Pasteurella dagmatis β-D-galactoside sialyltransferase by active-site redesign Show publication in TUGRAZonline
Kerstin Steiner, Anton Glieder and Mandana Gruber Cyanohydrin Formation / Henry ReactionSience of Synthesis1 - 5 Show publication in TUGRAZonline
Romana Wiedner, Bettina Kothbauer, Tea Pavkov-Keller, Mandana Gruber, Karl Gruber, Helmut Schwab and Kerstin Steiner Improving the Properties of Bacterial R-selective Hydroxynitrile Lyases for Industrial Applications Show publication in TUGRAZonline
Anita Emmerstorfer, Miriam Wimmer-Teubenbacher, Tamara Wriessnegger, Erich Leitner, Monika Müller, Iwona Kaluzna, Martin Schürmann, Daniel Mink, Günther Zellnig, Helmut Schwab and Harald Pichler Over-expression of ICE2 stabilizes cytochrome P450 reductase levels in Saccharomyces cerevisiae and Pichia pastoris Show publication in TUGRAZonline
Sandy Schmidt, Christian Scherkus, Jan Muschiol, Ulf Menyes, Till Winkler, Werner Hummel, Harald Gröger, Andreas Liese, Hans Georg Herz and Uwe T. Bornscheuer Eine Enzymkaskade zur Synthese von ε-Caprolacton und dessen Oligomeren Show publication in PURE
Armin Erlacher, Tomislav Cernava, Massimiliano Cardinale, Jung Soh, Christoph Wilhelm Sensen, Martin Grube and Gabriele Berg Rhizobiales as functional and endosymbiontic members in the lichen symbiosis of Lobaria pulmonaria L. Show publication in PURE
Matthias Engleder, Tea Pavkov-Keller, Anita Emmerstorfer, Hromic Altijana, Sabine Schrempf, Georg Steinkellner, Tamara Wriessnegger, Erich Leitner, Gernot Strohmeier, Iwona Kaluzna, Mink Daniel, Schürmann Martin, Silvia Wallner, Peter Macheroux, Karl Gruber and Harald Pichler Structure-based mechanism of oleate hydratase from Elizabethkingia meningoseptica Show publication in PURE
Florian Krainer, Simona Capone, Martin Jäger, Thomas Vogl, Michaela Agnes Gerstmann, Anton Glieder, Christoph Herwig and Oliver Spadiut Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris. Show publication in PURE
Ryan A. Groves, Jillian M. Hagel, Ye Zhang, Kilpatrick Korey, Levy Asaf, Marsolais Frederic, Lewinsohn Efraim, Christoph Wilhelm Sensen and Peter J. Facchini Transcriptome Profiling of Khat (Catha edulis) and Ephedra sinica Reveals Gene Candidates Potentially Involved in Amphetamine-Type Alkaloid Biosynthesis. Show publication in PURE
Anita Emmerstorfer, Miriam Wimmer-Teubenbacher, Tamara Wriessnegger, Erich Leitner, Monika Müller, Iwona Kaluzna, Martin Schürmann, Daniel Mink, Günther Zellnig, Helmut Schwab and Harald Pichler Over-expression of ICE2 stabilizes cytochrome P450 reductase levels in Saccharomyces cerevisiae and Pichia pastoris Show publication in PURE
Jürgen Hartler LIPID MAPS: Tools and DatabasesEncyclopedia of Lipidomics Show publication in PURE
Elisa Lanfranchi, Eva-Maria Köhler, Barbara Darnhofer, Kerstin Steiner, Ruth Birner-Grünberger, Anton Glieder and Margit Winkler Bioprospecting for Hydroxynitrile Lyases by Blue Native PAGE Coupled HCN Detection Show publication in PURE
Romana Wiedner, Bettina Kothbauer, Tea Pavkov-Keller, Mandana Gruber, Karl Gruber, Helmut Schwab and Kerstin Steiner Improving the Properties of Bacterial R-selective Hydroxynitrile Lyases for Industrial Applications Show publication in PURE
Jillian M. Hagel, Jeremy S. Morris, Eun-Jeong Lee, Isabel Desgagne-Penix, Crystal D. Bross, Limei Chang, Xue Chen, Scott C. Farrow, Ye Zhang, Jung Soh, Christoph Wilhelm Sensen and Peter J. Facchini Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. Show publication in PURE
Margit Winkler Drug Metabolite Synthesis with Human Enzymes Show publication in PURE
UM Tran, U. Rajarajacholan, Jung Soh, TS Kim, S. Thalappilly, Christoph Wilhelm Sensen and Karl Riabowol LincRNA-p21 acts as a mediator of ING1b-induced apoptosis Show publication in PURE
Jürgen Hartler MassBankEncyclopedia of Lipidomics1-3 Show publication in PURE
Thomas Vogl, Mudassar Ahmad, Florian Krainer, Helmut Schwab and Anton Glieder Restriction site free cloning (RSFC) plasmid family for seamless, sequence independent cloning in Pichia pastoris Show publication in PURE
Bastian Daniel, Tea Pavkov-Keller, Barbara Steiner, Angela Dodic, Alexander Gutmann, Bernd Nidetzky, Christoph Wilhelm Sensen, Eric van der Graaff, Silvia Wallner, Karl Gruber and Peter Macheroux Oxidation of monolignols by members of the berberine bridge enzyme family suggests a role in plant cell wall metabolism Show publication in PURE
Magali Tanghe, Barbara Danneels, Andrea Camattari, Anton Glieder, Isabel Vandenberghe, Bart Devreese, Ingeborg Stals and Tom Desmet Recombinant Expression of Trichoderma reesei Cel61A in Pichia pastoris Show publication in PURE
Corinna Odar, Margit Winkler and Birgit Wiltschi FLUORINATED AMINO ACIDS – A RARITY IN NATURE YET A PROSPECT FOR PROTEIN ENGINEERING Show publication in PURE
Julia Pitzer, Bob Van Hove, Aaron M. Love, Parayil Kumaran Ajikumar, Marjan De Mey and Anton Glieder Novel DNA and RNA elementsSynthetic Biology65-99 Show publication in PURE
Man-Ling Wong, Dongshan An, Sean Caffrey, Jung Soh, Xiaoli Dong, Christoph Wilhelm Sensen, Thomas Oldenburg, Stephen R. Larter and Gerrit Voordouw Roles of Thermophiles and Fungi in Bitumen Degradation in Mostly Cold Oil Sands Outcrops Show publication in PURE
Katharina Schmoelzer, Tibor Czabany, Christiane Luley, Tea Pavkov-Keller, Doris Ribitsch, Helmut Schwab, Karl Gruber, Hansjörg Weber and Bernd Nidetzky Complete switch from α-2,3- to α-2,6-regioselectivity in Pasteurella dagmatis β-D-galactoside sialyltransferase by active-site redesign Show publication in PURE
Florian Krainer and Anton Glieder An updated view on horseradish peroxidases: recombinant production and biotechnological applications. Show publication in PURE
Martina Geier, Thorsten Bachler, Steven P Hanlon, Fabian K Eggimann, Matthias Kittelmann, Hansjörg Weber, Stephan Lütz, Beat Wirz and Margit Winkler Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis Show publication in PURE
Shosuke Yoshida, Junichi Enoki, Robert Kourist and Kenji Miyamoto Engineered hydrophobic pocket of (S)-selective arylmalonate decarboxylase variant by simultaneous saturation mutagenesis to improve catalytic performance Show publication in PURE
Thomas Eichmann, Lukas Grumet, Ulrike Taschler, Jürgen Hartler, Christoph Heier, Aaron Woblistin, Laura Pajed, Manfred Kollroser, Gerald Rechberger, Gerhard G. Thallinger, Rudolf Zechner, Guenter Haemmerle, Robert Zimmermann and Achim Lass ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6 Show publication in PURE
Armin Erlacher, Tomislav Cernava, Massimiliano Cardinale, Jung Soh, Christoph Wilhelm Sensen, Martin Grube and Gabriele Berg Rhizobiales as functional and endosymbiontic members in the lichen symbiosis Lobaria pulmonaria L.. Show publication in PURE
Ioannis Zachos, Sarah Katharina Gaßmeyer, Daniel Bauer, Volker Sieber, Frank Hollmann and Robert Kourist Photobiocatalytic decarboxylation for olefin synthesis Show publication in PURE
Atsuko Ikeda, Tetsuya Muneoka, Suguru Murakami, Ayaka Hirota, Yukari Yabuki, Takefumi Karashima, Kota Nakazono, Masahiro Tsuruno, Harald Pichler, Katsuhiko Shirahige, Yukiko Kodama, Toshi Shimamoto, Keiko Mizuta and Kouichi Funato Sphingolipids regulate telomere clustering by affecting transcriptional levels of genes involved in telomere homeostasis Show publication in PURE
Thorsten Masuch, Anna Kusnezowa, Sebastian Nilewski, José T Bautista, Robert Kourist and Lars I Leichert A combined bioinformatics and functional metagenomics approach to discovering lipolytic biocatalysts Show publication in PURE
Robert Kourist A New Class of Enzymes Discovered: A Non-Heme Oxidase Produces Medium-Chain 1-Alkenes Show publication in PURE
M. Bartsch, S.K. Gaßmeyer, K. Igarashi, M. Miyamoto, M. Rögner, M. Nowaczyc and R. Kourist Expression of enantioselective enzymes in cyanobacteria Show publication in PURE
Astrid Weninger, Anton Glieder and Thomas Vogl A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris Show publication in PURE
Ivan Hajnal, Kurt Faber, Helmut Schwab, Melanie Hall and Kerstin Steiner Oxidative Alkene Cleavage Catalysed by Manganese-​Dependent Cupin TM1459 from Thermotoga maritima Show publication in PURE
Martina Geier, Christoph Brandner, Gernot A Strohmeier, Mélanie Hall, Franz Stefan Hartner and Anton Glieder Engineering Pichia pastoris for improved NADH regeneration Show publication in PURE
B. Tan, Jane Fowler, N.A. Laban, Xiaoli Dong, Christoph Wilhelm Sensen, Julia Foght and Lisa M. Gieg Comparative analysis of metagenomes from three methanogenic hydrocarbon-degrading enrichment cultures with 41 environmental samples. Show publication in PURE
Petra Köfinger, Steffen Gruber and Helmut Schwab Versatile plasmid-based expression systems for Gram-negative bacteria-General essentials exemplified with the bacterium Ralstonia eutropha H16. Show publication in PURE
Jürgen Hartler LipidHomeEncyclopedia of Lipidomics1-3 Show publication in PURE
Martina Geier, Pia Carina Fauland, Thomas Vogl and Anton Glieder Compact multi-enzyme pathways in P. pastoris Show publication in PURE
Kerstin Steiner, Anton Glieder and Mandana Gruber Cyanohydrin Formation / Henry ReactionSience of Synthesis1-5 Show publication in PURE
Margit Winkler, Katharina Dokulil, Hansjörg Weber, Tea Pavkov-Keller and Birgit Wilding The Nitrile forming Enzyme 7-Cyano-7-deazaguanine Synthase from Geobacillus kaustophilus: A reverse Nitrilase? Show publication in PURE
2014
Katrin Weinhandl, Margit Winkler, Anton Glieder and Andrea Camattari Extracellular transaminases for biocatalysis New BiotechnologyS198 - S198 Show publication in TUGRAZonline
Margit Winkler, Martina Geier, Thorsten Bachler, Steven P Hanlon, Matthias Kittelmann, Anton Glieder, Stephan Lütz and Beat Wirz Human flavin monooxygenase 2: Heterologous expression in E. coli and API modificationNew BiotechnologyS82 - S82 Show publication in TUGRAZonline
Steffen Gruber, Jeremias Hagen, Helmut Schwab and Petra Köfinger Versatile and stable vectors for efficient gene expression in Ralstonia eutropha H16 Show publication in TUGRAZonline
Aleksandra Mitrovic and Anton Glieder Discovery of fungal enzymes and pathwaysFungal Bio-Molecules: Sources, Applications and Recent Developments51 - 61 Show publication in TUGRAZonline
Oliver Spadiut, Simona Capone, Florian Krainer, Anton Glieder and Christoph Herwig Microbials for the production of monoclonal antibodies and antibody fragments Show publication in TUGRAZonline
Aleksandra Mitrovic, Karlheinz Flicker, Georg Steinkellner, Karl Gruber, Christoph Reisinger, Christoph Schirrmacher, Andrea Camattari and Anton Glieder Thermostability improvement of endoglucanase Cel7B from Hypocrea pseudokoningii Show publication in TUGRAZonline
Barbara Petschacher, Nicole Staunig, Monika Mueller, Martin Schuermann, Daniel Mink, Stefaan Wildemann, Karl Gruber and Anton Glieder Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD (P)+ Regeneration in Biocatalytic Oxidations Show publication in TUGRAZonline
Shuke Wu, Yongzheng Chen, Yi Xu, Anton Glieder and Zhi Li Enantioselective trans-dihydroxylation of aryl olefins by cascade biocatalysis with recombinant escherichia coli coexpressing monooxygenase and epoxide hydrolase Show publication in TUGRAZonline
Andrea Mellitzer, Claudia Ruth, Claes Gustafson, Mark Welch, Ruth Birner-Gruenberger, Roland Weis, Thomas Purkarthoer and Anton Glieder Synergistic modular promoter and gene optimization to push cellulase secretion by Pichia pastoris beyond existing benchmarks Show publication in TUGRAZonline
Oliver Spadiut, Simona Capone, Florian Krainer, Anton Glieder and Christoph Herwig Microbials for the production of monoclonal antibodies and antibody fragments. Show publication in TUGRAZonline
Florian Krainer, Robert Pletzenauer, Laura Rossetti, Christoph Herwig, Anton Glieder and Oliver Spadiut Purification and basic biochemical characterization of 19 recombinant plant peroxidase isoenzymes produced in Pichia pastoris. Show publication in TUGRAZonline
Laura Näätsaari, Florian Krainer, Michael Schubert, Anton Glieder and Gerhard Thallinger Peroxidase gene discovery from the horseradish transcriptome Show publication in TUGRAZonline
Thomas Vogl, Gerhard Thallinger, Günther Zellnig, David Drew, James Cregg, Anton Glieder and Maria Elisabeth Freigaßner Towards improved membrane protein production in Pichia pastoris: general and specific transcriptional response to membrane protein overexpression Show publication in TUGRAZonline
Doris Ribitsch, Sabine Zitzenbacher, Peter Andreas Augustin, Katharina Schmoelzer, Christiane Luley, Marco Thomann, Christine Jung, Harald Sobek, Rainer Müller, Bernd Nidetzky and Helmut Schwab High-quality production of human α-2,6-sialyltransferase in Pichia pastoris requires control over N-terminal truncations by host-inherent protease activities Show publication in TUGRAZonline
Antje Chang, Ida Schomburg, Sandra Placzek, Lisa Jeske, Markus Ulbrich, Mei Xiao, Christoph Wilhelm Sensen and Dietmar Schomburg BRENDA in 2015: exciting developments in its 25th year of existence. Show publication in TUGRAZonline
Martin Grube, Tomislav Cernava, J. Soh, S. Fuchs, Ines Aschenbrenner, C. Lassek, U Wegener, K. Riedel, Christoph Wilhelm Sensen and Gabriele Berg Exploring a functional network of symbiotic sustain with the microbiome of lichens and comparative omics Show publication in TUGRAZonline
Michael Karbiener, Christina Glantschnig and Marcel Scheideler Hunting the needle in the haystack - A guide to obtain biologically meaningful microRNA targets Show publication in TUGRAZonline
Ronald Gstir, Simon Schafferer, Marcel Scheideler, M Misslinger, Matthias Griehl, N Daschil, C Humpel, GJ Obermair, C Schuckermair, J Striessnig, BE Flucher and Alexander Hüttenhofer Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases. Show publication in TUGRAZonline
Katharina Schmoelzer, Christiane Luley, Tibor Czabany, Doris Ribitsch, Helmut Schwab, Hansjörg Weber and Bernd Nidetzky Mechanistic study of CMP-Neu5Ac hydrolysis by α2,3-sialyltransferase from Pasteurella dagmatis Show publication in TUGRAZonline
Michael Karbiener and Marcel Scheideler MicroRNA functions in brite/brown fat - novel perspectives towards anti-obesity strategies Show publication in TUGRAZonline
Ryan Lauchli, Julia Pitzer, Rebekah Z. Kitto, Karolina Z. Kalbarczyk and Kersten S. Rabe Improved selectivity of an engineered multi-product terpene synthase Show publication in TUGRAZonline
Barbara Petschacher, Nicole Staunig, Monika Müller, Martin Schürmann, Daniel Mink, Stefaan DeWildeman, Karl Gruber and Anton Glieder Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD(P)(+) Regeneration in Biocatalytic Oxidations. Show publication in TUGRAZonline
Claudia Ruth, Markus Buchetics , Viktorija Vidimce, Daniela Kotz, Stefan Naschberger, Diethard Mattanovich, Harald Pichler and Brigitte Gasser Pichia pastoris Aft1 - a novel transcription factor, enhancing recombinant protein secretion Show publication in TUGRAZonline
Andreas Maccani, Matthias Hackl, Christian Leitner, Nadine E. Tatto, Michael Karbiener, Marcel Scheideler, Johannes Grillari, Diethard Mattanovich, Renate Kunert, Nicole Borth, Reingard Grabherr and Wolfgang Ernst Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation Show publication in TUGRAZonline
Ludger Wessjohann, Martin Dippe, Martin Tengg and Mandana Gruber Methyltransferases in biocatalysisCascade Biocatalysis: Stereoselective and Environmentally Friendly Reactionsn/a - n/a Show publication in TUGRAZonline
Romana Wiedner, Mandana Gruber, Helmut Schwab and Kerstin Steiner Discovery of a novel (R)-selective bacterial cupin HNL from Acidobacterium capsulatum ATCC 51196 by a sequence-based approach Show publication in TUGRAZonline
Margit Winkler, Kamilla Napora-Wijata, Birgit Wilding and Norbert Klempier Unconventional Enzymatic Reductions: Nitriles and Carboxylates as SubstratesNew BiotechnologyS1 - S2 Show publication in TUGRAZonline
Anita Emmerstorfer, Tamara Wriessnegger, Melanie Hirz and Harald Pichler Overexpression of membrane proteins from higher eukaryotes in yeasts Show publication in TUGRAZonline
Ian Reid, Nick O'Toole, Omar Zabaneh, Reza Nourzadeh, Mike Dahdouli, Mostafa Abdellateef, Paul M. Gordon, Jung Soh, Greg Butler, Christoph Wilhelm Sensen and Adrian Tsang SnowyOwl: accurate prediction of fungal genes by using RNA-Seq and homology information to select ab initio models. Show publication in TUGRAZonline
RJ Gruninger, Christoph Wilhelm Sensen, TA McAllister and RJ Forster Diversity of Rumen Bacteria in Canadian Cervids Show publication in TUGRAZonline
Marcel Scheideler, Michael Karbiener, Eleonore Lang, Lisa Maria Oberreiter, Christina Glantschnig, Didier Pisani, Gérard Ailhaud and Ez-Zoubir Amri MicroRNA functions in human fat cell development - Novel perspectives towards anti-obesity strategiesBIT´s Annual World Congress of Molecular & Cell Biology - 2014124 - 124 Show publication in TUGRAZonline
Georg Steinkellner, Christian C. Gruber, Tea Pavkov-Keller, Alexandra Binter, Kerstin Steiner, Christoph Winkler, Andrzej Lyskowski, Orsolya Schwamberger, Monika Oberer, Helmut Schwab, Kurt Faber, Peter Macheroux and Karl Gruber Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations Show publication in TUGRAZonline
Tamara Wriessnegger, Peter Andreas Augustin, Matthias Engleder, Erich Leitner, Monika Müller, Iwona Kaluzna, Martin Schürmann, Daniel Mink, Günther Zellnig, Helmut Schwab and Harald Pichler Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastors Show publication in TUGRAZonline
Michael Felber, Harald Pichler and Claudia Ruth Strains and Molecular Tools for Recombinant Protein Production in Pichia pastorisYeast Metabolic Engineering: Methods and Protocols87 - 111 Show publication in TUGRAZonline
Ahmad Mudassar, Melanie Hirz, Harald Pichler and Helmut Schwab Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production Show publication in TUGRAZonline
Steven P. Hanlon, Matthias Kittelmann and Margit Winkler SEMI-PREPARATIVE SCALE DRUG METABOLITE SYNTHESIS WITH HUMAN FLAVIN MONOOXYGENASESPractical Methods in Biocatalysis and Biotransformationsn/a - n/a Show publication in TUGRAZonline
Diogo Rodrigues, Matthias Kittelmann, Fabian Eggimann, Thorsten Bachler, Sandra Abad, Andrea Camattari, Anton Glieder, Margit Winkler and Stephan Lütz PRODUCTION OF RECOMBINANT HUMAN ALDEHYDE OXIDASE IN E. COLI AND OPTIMIZATION OF ITS APPLICATION FOR PREPARATIVE SYNTHESIS OF OXIDIZED DRUG METABOLITES Show publication in TUGRAZonline
Kamila Napora, Gernot Strohmeier and Margit Winkler BIOCATALYTIC REDUCTION OF CARBOXYLIC ACIDS Show publication in TUGRAZonline
Alexander Deutsch, Beate Rinner, Kerstin Wenzl, Martin Pichler, Katharina Troppan, Elisabeth Steinbauer, Daniela Schwarzenbacher, Sonja Reitter, Julia Feichtinger, Sascha Tierling, Andreas Prokesch, Marcel Scheideler, Anne Krogsdam, Gerhard Thallinger, Helmut Schaider, Christine Beham-Schmid and Peter Neumeister NR4A1-mediated apoptosis supresses lymphomagenesis and is associated with a favorable cancer specific survival in patients with aggressive B-cell lymphomas Show publication in TUGRAZonline
Matthias Hackl, Vaibhav Jadhav, Gerald Klanert, Michael Karbiener, Marcel Scheideler, Johannes Grillari and Nicole Borth Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation Show publication in TUGRAZonline
Andrzej Franciszek Lyskowski, Christian Gruber, Georg Steinkellner, M Schuermann, Helmut Schwab, Karl Gruber and Kerstin Steiner Crystal structure of an (R)-selective ω-transaminase from Aspergillus terreus (R)-selective ω-transaminase from Aspergillus terre Show publication in TUGRAZonline
Katrin Weinhandl, Margit Winkler, Anton Glieder and Andrea Camattari Carbon source dependent promoters in yeasts Show publication in TUGRAZonline
Martin Pichler, Anna Ress, Elke Winter, Verena Stiegelbauer, Michael Karbiener, Daniela Schwarzenbacher, Marcel Scheideler, Cristina Ivan, Stephan Jahn, Tobias Kiesllich, Armin Gerger, Thomas Bauernhofer, George Calin and Gerald Höfler MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients Show publication in TUGRAZonline
Michael Karbiener, Didier Pisani, Andrea Frontini, Lisa Maria Oberreiter, Eleonore Lang, Alexandros Vegiopoulos, Karin Mössenböck, Gerwin Bernhardt, Torsten Mayr, Florian Hildner, Johannes Grillari, Gerard Ailhaud, Stephan Herzig, Saverio Cinti, Ez-Zoubir Amri and Marcel Scheideler MicroRNA-26 family is required for human adipogenesis and drives brown adipocytes characteristics Show publication in TUGRAZonline
Michael Karbiener and Marcel Scheideler MicroRNA functions in brite/brown fat - novel perspectives towards anti-obesity strategies Show publication in PURE
Laura Näätsaari, Florian Krainer, Michael Schubert, Anton Glieder and Gerhard Thallinger Peroxidase gene discovery from the horseradish transcriptome Show publication in PURE
Ryan Lauchli, Julia Pitzer, Rebekah Z. Kitto, Karolina Z. Kalbarczyk and Kersten S. Rabe Improved selectivity of an engineered multi-product terpene synthase Show publication in PURE
Oliver Spadiut, Simona Capone, Florian Krainer, Anton Glieder and Christoph Herwig Microbials for the production of monoclonal antibodies and antibody fragments Show publication in PURE
Marcel Scheideler, Michael Karbiener, Eleonore Lang, Lisa Maria Oberreiter, Christina Glantschnig, Didier Pisani, Gérard Ailhaud and Ez-Zoubir Amri MicroRNA functions in human fat cell development - Novel perspectives towards anti-obesity strategiesBIT´s Annual World Congress of Molecular & Cell Biology - 2014124-124 Show publication in PURE
Margit Winkler, Martina Geier, Thorsten Bachler, Steven P Hanlon, Matthias Kittelmann, Anton Glieder, Stephan Lütz and Beat Wirz Human flavin monooxygenase 2: Heterologous expression in E. coli and API modificationNew BiotechnologyS82-S82 Show publication in PURE
Margit Winkler, Kamilla Napora-Wijata, Birgit Wilding and Norbert Klempier Unconventional Enzymatic Reductions: Nitriles and Carboxylates as SubstratesNew BiotechnologyS1-S2 Show publication in PURE
Katrin Weinhandl, Margit Winkler, Anton Glieder and Andrea Camattari Extracellular transaminases for biocatalysisNew BiotechnologyS198-S198 Show publication in PURE
Anita Emmerstorfer, Tamara Wriessnegger, Melanie Hirz and Harald Pichler Overexpression of membrane proteins from higher eukaryotes in yeasts Show publication in PURE
Ludger Wessjohann, Martin Dippe, Martin Tengg and Mandana Gruber Methyltransferases in biocatalysisCascade Biocatalysis: Stereoselective and Environmentally Friendly Reactions Show publication in PURE
Steffen Gruber, Jeremias Hagen, Helmut Schwab and Petra Köfinger Versatile and stable vectors for efficient gene expression in Ralstonia eutropha H16 Show publication in PURE
Katharina Schmoelzer, Christiane Luley, Tibor Czabany, Doris Ribitsch, Helmut Schwab, Hansjörg Weber and Bernd Nidetzky Mechanistic study of CMP-Neu5Ac hydrolysis by α2,3-sialyltransferase from Pasteurella dagmatis Show publication in PURE
Tamara Wriessnegger, Peter Andreas Augustin, Matthias Engleder, Erich Leitner, Monika Müller, Iwona Kaluzna, Martin Schürmann, Daniel Mink, Günther Zellnig, Helmut Schwab and Harald Pichler Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastors Show publication in PURE
Ian Reid, Nick O'Toole, Omar Zabaneh, Reza Nourzadeh, Mike Dahdouli, Mostafa Abdellateef, Paul M. Gordon, Jung Soh, Greg Butler, Christoph Wilhelm Sensen and Adrian Tsang SnowyOwl: accurate prediction of fungal genes by using RNA-Seq and homology information to select ab initio models. Show publication in PURE
Martin Pichler, Anna Ress, Elke Winter, Verena Stiegelbauer, Michael Karbiener, Daniela Schwarzenbacher, Marcel Scheideler, Cristina Ivan, Stephan Jahn, Tobias Kiesllich, Armin Gerger, Thomas Bauernhofer, George Calin and Gerald Höfler MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients Show publication in PURE
Claudia Ruth, Markus Buchetics, Viktorija Vidimce, Daniela Kotz, Stefan Naschberger, Diethard Mattanovich, Harald Pichler and Brigitte Gasser Pichia pastoris Aft1 - a novel transcription factor, enhancing recombinant protein secretion Show publication in PURE
Katrin Weinhandl, Margit Winkler, Anton Glieder and Andrea Camattari Carbon source dependent promoters in yeasts Show publication in PURE
Barbara Petschacher, Nicole Staunig, Monika Mueller, Martin Schuermann, Daniel Mink, Stefaan Wildemann, Karl Gruber and Anton Glieder Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD (P)+ Regeneration in Biocatalytic Oxidations Show publication in PURE
Ahmad Mudassar, Melanie Hirz, Harald Pichler and Helmut Schwab Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production Show publication in PURE
RJ Gruninger, Christoph Wilhelm Sensen, TA McAllister and RJ Forster Diversity of Rumen Bacteria in Canadian Cervids Show publication in PURE
Florian Krainer, Robert Pletzenauer, Laura Rossetti, Christoph Herwig, Anton Glieder and Oliver Spadiut Purification and basic biochemical characterization of 19 recombinant plant peroxidase isoenzymes produced in Pichia pastoris. Show publication in PURE
Andrea Mellitzer, Claudia Ruth, Claes Gustafson, Mark Welch, Ruth Birner-Gruenberger, Roland Weis, Thomas Purkarthoer and Anton Glieder Synergistic modular promoter and gene optimization to push cellulase secretion by Pichia pastoris beyond existing benchmarks Show publication in PURE
Kamila Napora, Gernot Strohmeier and Margit Winkler BIOCATALYTIC REDUCTION OF CARBOXYLIC ACIDS Show publication in PURE
Aleksandra Mitrovic and Anton Glieder Discovery of fungal enzymes and pathwaysFungal Bio-Molecules: Sources, Applications and Recent Developments51-61 Show publication in PURE
Antje Chang, Ida Schomburg, Sandra Placzek, Lisa Jeske, Markus Ulbrich, Mei Xiao, Christoph Wilhelm Sensen and Dietmar Schomburg BRENDA in 2015: exciting developments in its 25th year of existence. Show publication in PURE
Thomas Vogl, Claudia Ruth, Julia Pitzer, Thomas Kickenweiz and Anton Glieder Synthetic Core Promoters for Pichia pastoris Show publication in PURE
Andreas Maccani, Matthias Hackl, Christian Leitner, Nadine E. Tatto, Michael Karbiener, Marcel Scheideler, Johannes Grillari, Diethard Mattanovich, Renate Kunert, Nicole Borth, Reingard Grabherr and Wolfgang Ernst Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation Show publication in PURE
Shuke Wu, Yongzheng Chen, Yi Xu, Anton Glieder and Zhi Li Enantioselective trans-dihydroxylation of aryl olefins by cascade biocatalysis with recombinant escherichia coli coexpressing monooxygenase and epoxide hydrolase Show publication in PURE
L Hilterhaus and R Kourist Microbial Lactone Synthesis Based on Renewable Resources Show publication in PURE
Ronald Gstir, Simon Schafferer, Marcel Scheideler, M Misslinger, Matthias Griehl, N Daschil, C Humpel, GJ Obermair, C Schuckermair, J Striessnig, BE Flucher and Alexander Hüttenhofer Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases. Show publication in PURE
Michael Karbiener, Didier Pisani, Andrea Frontini, Lisa Maria Oberreiter, Eleonore Lang, Alexandros Vegiopoulos, Karin Mössenböck, Gerwin Bernhardt, Torsten Mayr, Florian Hildner, Johannes Grillari, Gerard Ailhaud, Stephan Herzig, Saverio Cinti, Ez-Zoubir Amri and Marcel Scheideler MicroRNA-26 family is required for human adipogenesis and drives brown adipocytes characteristics Show publication in PURE
Georg Steinkellner, Christian C. Gruber, Tea Pavkov-Keller, Alexandra Binter, Kerstin Steiner, Christoph Winkler, Andrzej Lyskowski, Orsolya Schwamberger, Monika Oberer, Helmut Schwab, Kurt Faber, Peter Macheroux and Karl Gruber Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations Show publication in PURE
Diogo Rodrigues, Matthias Kittelmann, Fabian Eggimann, Thorsten Bachler, Sandra Abad, Andrea Camattari, Anton Glieder, Margit Winkler and Stephan Lütz PRODUCTION OF RECOMBINANT HUMAN ALDEHYDE OXIDASE IN E. COLI AND OPTIMIZATION OF ITS APPLICATION FOR PREPARATIVE SYNTHESIS OF OXIDIZED DRUG METABOLITES Show publication in PURE
R Kourist, F. Hollmann and G. S. Nguyen Lipases as Sustainable Biocatalysts for the Sustainable Industrial Production of Fine Chemicals and Cosmetics Show publication in PURE
Thomas Vogl, Gerhard Thallinger, Günther Zellnig, David Drew, James Cregg, Anton Glieder and Maria Elisabeth Freigaßner Towards improved membrane protein production in Pichia pastoris: general and specific transcriptional response to membrane protein overexpression Show publication in PURE
Robert Kourist, Jan-Karl Guterl, Kenji Miyamoto and Volker Sieber Enzymatic decarboxylation—an emerging reaction for chemicals production from renewable resources Show publication in PURE
Aleksandra Mitrovic, Karlheinz Flicker, Georg Steinkellner, Karl Gruber, Christoph Reisinger, Christoph Schirrmacher, Andrea Camattari and Anton Glieder Thermostability improvement of endoglucanase Cel7B from Hypocrea pseudokoningii Show publication in PURE
Thomas Brück, Robert Kourist and Bernhard Loll Production of macrocyclic sesqui‐and diterpenes in heterologous microbial hosts: A systems approach to harness Nature’s molecular diversity Show publication in PURE
Matthias Hackl, Vaibhav Jadhav, Gerald Klanert, Michael Karbiener, Marcel Scheideler, Johannes Grillari and Nicole Borth Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation Show publication in PURE
Martin Grube, Tomislav Cernava, J. Soh, S. Fuchs, Ines Aschenbrenner, C. Lassek, U Wegener, K. Riedel, Christoph Wilhelm Sensen and Gabriele Berg Exploring a functional network of symbiotic sustain with the microbiome of lichens and comparative omics Show publication in PURE
Doris Ribitsch, Sabine Zitzenbacher, Peter Andreas Augustin, Katharina Schmoelzer, Christiane Luley, Marco Thomann, Christine Jung, Harald Sobek, Rainer Müller, Bernd Nidetzky and Helmut Schwab High-quality production of human α-2,6-sialyltransferase in Pichia pastoris requires control over N-terminal truncations by host-inherent protease activities Show publication in PURE
Steven P. Hanlon, Matthias Kittelmann and Margit Winkler SEMI-PREPARATIVE SCALE DRUG METABOLITE SYNTHESIS WITH HUMAN FLAVIN MONOOXYGENASESPractical Methods in Biocatalysis and Biotransformations135-139 Show publication in PURE
Michael Karbiener, Christina Glantschnig and Marcel Scheideler Hunting the needle in the haystack - A guide to obtain biologically meaningful microRNA targets Show publication in PURE
Michael Felber, Harald Pichler and Claudia Ruth Strains and Molecular Tools for Recombinant Protein Production in Pichia pastorisYeast Metabolic Engineering: Methods and Protocols87-111 Show publication in PURE
Alexander Deutsch, Beate Rinner, Kerstin Wenzl, Martin Pichler, Katharina Troppan, Elisabeth Steinbauer, Daniela Schwarzenbacher, Sonja Reitter, Julia Feichtinger, Sascha Tierling, Andreas Prokesch, Marcel Scheideler, Anne Krogsdam, Gerhard Thallinger, Helmut Schaider, Christine Beham-Schmid and Peter Neumeister NR4A1-mediated apoptosis supresses lymphomagenesis and is associated with a favorable cancer specific survival in patients with aggressive B-cell lymphomas Show publication in PURE
Romana Wiedner, Mandana Gruber, Helmut Schwab and Kerstin Steiner Discovery of a novel (R)-selective bacterial cupin HNL from Acidobacterium capsulatum ATCC 51196 by a sequence-based approach Show publication in PURE
Andrzej Franciszek Lyskowski, Christian Gruber, Georg Steinkellner, M Schuermann, Helmut Schwab, Karl Gruber and Kerstin Steiner Crystal structure of an (R)-selective ω-transaminase from Aspergillus terreus (R)-selective ω-transaminase from Aspergillus terre Show publication in PURE
2013
Martina Geier, Christian Schmid and Anton Glieder First functional expression of cytochrome P450 3A4 in Pichia pastoris Show publication in TUGRAZonline
Martina Geier, Andreas Braun, Patrick Fladischer, Piotr Stepniak, Florian Rudroff , Christoph Hametner , Marko Mihovilovic and Anton Glieder Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation Show publication in TUGRAZonline
Florian Krainer, Christoph Gmeiner, Lukas Neutsch, Markus Windwarder, Robert Pletzenauer, Christoph Herwig, Friedrich Altmann, Anton Glieder and Oliver Spadiut Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris Show publication in TUGRAZonline
Alireeza Saidi-Mehrabad, Zhiguo He, I. Tamas, C. E. Sharp , A. L. Brady, Fauziah F. Rochman, L. Bodrossy, G. C. J. Abell, T. Penner, Xiaoli Dong, Christoph Wilhelm Sensen and Peter F. Dunfield Methanotrophic bacteria in oilsands tailings ponds of northern Alberta Show publication in TUGRAZonline
Howard Wong, Jung Soh, Paul M. K. Gordon, Tom Yu, Christoph Wilhelm Sensen, Edward Parr and Randal N. Johnston Genomic Compartmentalization of Gene Families Encoding Core Components of Metazoan Signaling Systems Show publication in TUGRAZonline
Damian Paul Drew, Bjørn Dueholm, Corinna Weitzel, Ye Zhang , Christoph Wilhelm Sensen and Henrik Toft Simonsen Transcriptome Analysis of Thapsia laciniata Rouy provides insights into terpenoid biosynthesis and diversity in Apiaceae Show publication in TUGRAZonline
M. Xiao , Y. Zhang , X. Chen , E. J. Lee, C. J. Barber, R. Chakrabarty , I. Desgagné-Penix, T. M. Haslam, Y. B. Kim, E. Liu, G. MacNevin , S. Masada-Atsumi , D. W. Reed , J. M. Stout , B. Zerbe, Y. Zhang, J. Bohlmann , P. S. Covello, V. De Luca V, J. E. Page, D. K. Ro, V. J. Martin , P. J. Facchini and Christoph Wilhelm Sensen Tanscriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest Show publication in TUGRAZonline
Xiaoli Dong, Boonfei Tan, Christoph Wilhelm Sensen and Julia Foght Metagenomic analysis of an anerobic alkane-degrading microbial culture: Potential hydrocarbon-activating pathways and inferred roles of community members Show publication in TUGRAZonline
Jung Soh, Sean Caffrey, Gerrit Voordouw and Christoph Wilhelm Sensen Phoenix 2: a locally installable large-scale 16S rRNA gene sequence analysis pipeline with Web interface Show publication in TUGRAZonline
Dongshan An, Damon Brown, Xiaoli Dong, Esther Ramos-Padron, Sandra Wilson, Sylvain Bordenave, Sean Caffrey, Lisa M. Gieg, Christoph Wilhelm Sensen and Gerrit Voordouw Microbial community and potential functional gene diversity involved in anaerobic hydrocarbon degradation and methanogenesis in an oil sands tailings pond Show publication in TUGRAZonline
Dongshan An, Sean Caffrey, Jung Soh, Akhil Agrawal, Damon Brown, Karen Budwill, Xiaoli Dong, Peter F. Dunfield, Julia Foght, Lisa M. Gieg, Steven J. Hallam, Niels W. Hanson, Zhiguo He, Thomas R. Jack, Jonathan Klassen, Kishori M. Konwar, Eugene Kuatsjah, Carmen Li, Steve Larter, Verlyn Leopatra, Camilla L. Nesbø, Thomas Oldenburg, Antoine P. Pagé, Esther Ramos-Padron, Fauziah F. Rochman, Alireeza Saidi-Mehrabad, Christoph Wilhelm Sensen, Payal Sipahimalani, Young C. Song, Sandra Wilson, Gregor Wolbring, Man-Ling Wong and Gerrit Voordouw Metagenomics of Hydrocarbon Resource Environments indicates Aerobic Taxa and Genes to be unexpectedly common Show publication in TUGRAZonline
Yetunde Folarin, Dongshan An, Sean Caffrey, Jung Soh, Christoph Wilhelm Sensen, Johanna Voordouw, Tom Jack and Gerrit Voordouw Contribution of make-up water to the microbial community in an oil field from which oil is produced by produced water re-injection Show publication in TUGRAZonline
Ivan Hajnal, Andrzej Franciszek Lyskowski, Ulf Hanefeld, Karl Gruber, Helmut Schwab and Kerstin Steiner Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase Show publication in TUGRAZonline
F.G. Eikmeyer, Petra Köfinger, Andrea Poschenel, S Jünemann , M Zakrzewski , Stefan Heinl, Elisabeth Mayrhuber, Reingard Grabherr, Alf Pühler, Helmut Schwab and Andreas Schlüter Metagenome analyses reveal the influence of the inoculant Lactobacillus buchneri CD034 on the microbial community involved in grass ensiling Show publication in TUGRAZonline
Kateryna Fesko, Kerstin Steiner, Rolf Breinbauer, Helmut Schwab, Martin Schürmann and Gernot Strohmeier Investigation of one-enzyme systems in the w-transaminase-catalyzed synthesis of chiral amines Show publication in TUGRAZonline
Katharina Tauber, Michael Fuchs, Johann H. Sattler, Julia Pitzer, Desiree Pressnitz, Dominik Koszelewski, Kurt Faber, Jan Pfeffer, Thomas Haas and Wolfgang Kroutil Artificial Multi-Enzyme Networks for the Asymmetric Amination of sec-Alcohols Show publication in TUGRAZonline
Thomas Vogl, Claudia Ruth, Julia Pitzer, Thomas Kickenweiz and Anton Glieder Synthetic Core Promoters for Pichia pastoris Show publication in TUGRAZonline
Thomas Vogl New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris Show publication in TUGRAZonline
Thomas Vogl Regulation of Pichia pastoris promoters and its consequences for protein production Show publication in TUGRAZonline
Aashrita Rajagopalan, Markus Schober, Anita Emmerstorfer, Lucas Hammerer, Anna Migglautsch, Birgit Seisser, Silvia M Glück, Frank Niehaus, Jürgen Eck, Harald Pichler, Karl Gruber and Wolfgang Kroutil Enzymatic aerobic alkene cleavage catalyzed by a Mn3+-dependent proteinase A homologue. Show publication in TUGRAZonline
Katharina Schmoelzer, Doris Ribitsch, Tibor Czabany, Christiane Luley, Deja Kokot, Andrzej Franciszek Lyskowski, Sabine Zitzenbacher, Helmut Schwab and Bernd Nidetzky Characterization of a multifunctional α2,3-sialyltransferase from Pasteurella dagmatis Show publication in TUGRAZonline
Christine Winkler, Mudassar Ahmad, Peter Neugebauer, Helmut Schwab and Harald Pichler Probing the secretory pathway of the yeast Pichia pastorisBook of abstracts38 - 38 Show publication in TUGRAZonline
Tamara Wriessnegger, Anita Emmerstorfer, Monika Müller, Iwona Kaluzna, Helmut Schwab and Harald Pichler Terpenoid production in yeastsBook of abstracts26 - 26 Show publication in TUGRAZonline
Elisa Lanfranchi, Kerstin Steiner, Anton Glieder, Ivan Hajnal, Roger A. Sheldon, Sander van Pelt and Margit Winkler RECENT DEVELOPMENTS IN HYDROXYNITRILE LYASES FOR INDUSTRIAL BIOTECHNOLOGY Show publication in TUGRAZonline
Melanie Hirz, Gerald Richter, Erich Leitner, Tamara Wriessnegger and Harald Pichler A novel cholesterol-producing Pichia pastoris strain is an ideal host for functional expression of human Na,K-ATPase α3β1 isoform Show publication in TUGRAZonline
Birgit Wilding, Margit Winkler, Barbara Petschacher, Regina Kratzer, Sigrid Egger, Georg Steinkellner, Andrzej Franciszek Lyskowski, Bernd Nidetzky, Karl Gruber and Norbert Klempier Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering Show publication in TUGRAZonline
Enrique Herrero Acero, Doris Ribitsch, Anita Dellacher, Sabine Zitzenbacher, Annemarie Marold, Georg Steinkellner, Karl Gruber, Helmut Schwab and Georg Gübitz Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis Show publication in TUGRAZonline
Doris Ribitsch, Orcal Yebra Antonio, Sabine Zitzenbacher, Susanne Nowitsch, Georg Steinkellner, Katrin Julia Greimel, Doliška Aleš, Gustav Oberdorfer, Christian Gruber, Karl Gruber, Helmut Schwab, Stana-Kleinschek Karin, Enrique Herrero Acero and Georg Gübitz Fusion of binding-domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis Show publication in TUGRAZonline
Tamara Wriessnegger and Harald Pichler Yeast metabolic engineering - targeting sterol metabolism and terpenoid formation Show publication in TUGRAZonline
Kamila Napora, Tanja Wrodnigg, Patrick Kosmus, Martin Thonhofer, Karen Robins and Margit Winkler YARROWIA LIPOLYTICA DEHYDROGENASE/ REDUCTASE: AN ENZYME TOLERANT FOR LIPOPHILIC COMPOUNDS AND CARBOHYDRATE SUBSTRATES Show publication in TUGRAZonline
Martina Geier and Anton Glieder Protein Engineering Using Eukaryotic Expression SystemsProtein Engineering Handbook - Volume 347 - 72 Show publication in TUGRAZonline
Alireeza Saidi-Mehrabad, Zhiguo He, I. Tamas, C. E. Sharp, A. L. Brady, Fauziah F. Rochman, L. Bodrossy, G. C. J. Abell, T. Penner, Xiaoli Dong, Christoph Wilhelm Sensen and Peter F. Dunfield Methanotrophic bacteria in oilsands tailings ponds of northern Alberta Show publication in PURE
Aashrita Rajagopalan, Markus Schober, Anita Emmerstorfer, Lucas Hammerer, Anna Migglautsch, Birgit Seisser, Silvia M Glück, Frank Niehaus, Jürgen Eck, Harald Pichler, Karl Gruber and Wolfgang Kroutil Enzymatic aerobic alkene cleavage catalyzed by a Mn3+-dependent proteinase A homologue Show publication in PURE
Katharina Tauber, Michael Fuchs, Johann H. Sattler, Julia Pitzer, Desiree Pressnitz, Dominik Koszelewski, Kurt Faber, Jan Pfeffer, Thomas Haas and Wolfgang Kroutil Artificial Multi-Enzyme Networks for the Asymmetric Amination of sec-Alcohols Show publication in PURE
Yetunde Folarin, Dongshan An, Sean Caffrey, Jung Soh, Christoph Wilhelm Sensen, Johanna Voordouw, Tom Jack and Gerrit Voordouw Contribution of make-up water to the microbial community in an oil field from which oil is produced by produced water re-injection Show publication in PURE
Jung Soh, Sean Caffrey, Gerrit Voordouw and Christoph Wilhelm Sensen Phoenix 2: a locally installable large-scale 16S rRNA gene sequence analysis pipeline with Web interface Show publication in PURE
Florian Krainer, Christoph Gmeiner, Lukas Neutsch, Markus Windwarder, Robert Pletzenauer, Christoph Herwig, Friedrich Altmann, Anton Glieder and Oliver Spadiut Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris Show publication in PURE
Ivan Hajnal, Andrzej Franciszek Lyskowski, Ulf Hanefeld, Karl Gruber, Helmut Schwab and Kerstin Steiner Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase Show publication in PURE
Doris Ribitsch, Orcal Yebra Antonio, Sabine Zitzenbacher, Jing Wu, Susanne Nowitsch, Georg Steinkellner, Katrin Julia Greimel, Doliška Aleš, Gustav Oberdorfer, Christian Gruber, Karl Gruber, Helmut Schwab, Stana-Kleinschek Karin, Enrique Herrero Acero and Georg Gübitz Fusion of binding-domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis Show publication in PURE
Dongshan An, Damon Brown, Xiaoli Dong, Esther Ramos-Padron, Sandra Wilson, Sylvain Bordenave, Sean Caffrey, Lisa M. Gieg, Christoph Wilhelm Sensen and Gerrit Voordouw Microbial community and potential functional gene diversity involved in anaerobic hydrocarbon degradation and methanogenesis in an oil sands tailings pond Show publication in PURE
Tamara Wriessnegger and Harald Pichler Yeast metabolic engineering - targeting sterol metabolism and terpenoid formation Show publication in PURE
Xiaoli Dong, Boonfei Tan, Christoph Wilhelm Sensen and Julia Foght Metagenomic analysis of an anerobic alkane-degrading microbial culture: Potential hydrocarbon-activating pathways and inferred roles of community members Show publication in PURE
Martina Geier, Andreas Braun, Patrick Fladischer, Piotr Stepniak, Florian Rudroff, Christoph Hametner, Marko Mihovilovic and Anton Glieder Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation Show publication in PURE
M. Xiao, Y. Zhang, X. Chen, E. J. Lee, C. J. Barber, R. Chakrabarty, I. Desgagné-Penix, T. M. Haslam, Y. B. Kim, E. Liu, G. MacNevin, S. Masada-Atsumi, D. W. Reed, J. M. Stout, B. Zerbe, J. Bohlmann, P. S. Covello, V. De Luca V, J. E. Page, D. K. Ro, V. J. Martin, Christoph Wilhelm Sensen and Peter J. Facchini Tanscriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest Show publication in PURE
Dongshan An, Sean Caffrey, Jung Soh, Akhil Agrawal, Damon Brown, Karen Budwill, Xiaoli Dong, Peter F. Dunfield, Julia Foght, Lisa M. Gieg, Steven J. Hallam, Niels W. Hanson, Zhiguo He, Thomas R. Jack, Jonathan Klassen, Kishori M. Konwar, Eugene Kuatsjah, Carmen Li, Steve Larter, Verlyn Leopatra, Camilla L. Nesbø, Thomas Oldenburg, Antoine P. Pagé, Esther Ramos-Padron, Fauziah F. Rochman, Alireeza Saidi-Mehrabad, Christoph Wilhelm Sensen, Payal Sipahimalani, Young C. Song, Sandra Wilson, Gregor Wolbring, Man-Ling Wong and Gerrit Voordouw Metagenomics of Hydrocarbon Resource Environments indicates Aerobic Taxa and Genes to be unexpectedly common Show publication in PURE
Thomas Vogl Regulation of Pichia pastoris promoters and its consequences for protein production Show publication in PURE
Howard Wong, Jung Soh, Paul M. K. Gordon, Tom Yu, Christoph Wilhelm Sensen, Edward Parr and Randal N. Johnston Genomic Compartmentalization of Gene Families Encoding Core Components of Metazoan Signaling Systems Show publication in PURE
Kateryna Fesko, Kerstin Steiner, Rolf Breinbauer, Helmut Schwab, Martin Schürmann and Gernot Strohmeier Investigation of one-enzyme systems in the w-transaminase-catalyzed synthesis of chiral amines Show publication in PURE
Thomas Vogl New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris Show publication in PURE
Martina Geier, Christian Schmid and Anton Glieder First functional expression of cytochrome P450 3A4 in Pichia pastoris Show publication in PURE
Elisa Lanfranchi, Kerstin Steiner, Anton Glieder, Ivan Hajnal, Roger A. Sheldon, Sander van Pelt and Margit Winkler RECENT DEVELOPMENTS IN HYDROXYNITRILE LYASES FOR INDUSTRIAL BIOTECHNOLOGY Show publication in PURE
Damian Paul Drew, Bjørn Dueholm, Corinna Weitzel, Ye Zhang, Christoph Wilhelm Sensen and Henrik Toft Simonsen Transcriptome Analysis of Thapsia laciniata Rouy provides insights into terpenoid biosynthesis and diversity in Apiaceae Show publication in PURE
Birgit Wilding, Margit Winkler, Barbara Petschacher, Regina Kratzer, Sigrid Egger, Georg Steinkellner, Andrzej Franciszek Lyskowski, Bernd Nidetzky, Karl Gruber and Norbert Klempier Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering Show publication in PURE
Reina Wada, Takashi Kumon, Robert Kourist, Hiromichi Ohta, Daisuke Uemura, Shosuke Yoshida and Kenji Miyamoto Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants Show publication in PURE
Enrique Herrero Acero, Doris Ribitsch, Anita Dellacher, Sabine Zitzenbacher, Annemarie Marold, Georg Steinkellner, Karl Gruber, Helmut Schwab and Georg Gübitz Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis Show publication in PURE
Martina Geier and Anton Glieder Protein Engineering Using Eukaryotic Expression SystemsProtein Engineering Handbook - Volume 347-72 Show publication in PURE
F.G. Eikmeyer, Petra Köfinger, Andrea Poschenel, S Jünemann, M Zakrzewski, Stefan Heinl, Elisabeth Mayrhuber, Reingard Grabherr, Alf Pühler, Helmut Schwab and Andreas Schlüter Metagenome analyses reveal the influence of the inoculant Lactobacillus buchneri CD034 on the microbial community involved in grass ensiling Show publication in PURE
Kamila Napora, Tanja Wrodnigg, Patrick Kosmus, Martin Thonhofer, Karen Robins and Margit Winkler YARROWIA LIPOLYTICA DEHYDROGENASE/ REDUCTASE: AN ENZYME TOLERANT FOR LIPOPHILIC COMPOUNDS AND CARBOHYDRATE SUBSTRATES Show publication in PURE
Katharina Schmoelzer, Doris Ribitsch, Tibor Czabany, Christiane Luley, Deja Kokot, Andrzej Franciszek Lyskowski, Sabine Zitzenbacher, Helmut Schwab and Bernd Nidetzky Characterization of a multifunctional α2,3-sialyltransferase from Pasteurella dagmatis Show publication in PURE
Melanie Hirz, Gerald Richter, Erich Leitner, Tamara Wriessnegger and Harald Pichler A novel cholesterol-producing Pichia pastoris strain is an ideal host for functional expression of human Na,K-ATPase α3β1 isoform Show publication in PURE
Tamara Wriessnegger, Anita Emmerstorfer, Monika Müller, Iwona Kaluzna, Helmut Schwab and Harald Pichler Terpenoid production in yeastsBook of abstracts26-26 Show publication in PURE
Christine Winkler, Mudassar Ahmad, Peter Neugebauer, Helmut Schwab and Harald Pichler Probing the secretory pathway of the yeast Pichia pastorisBook of abstracts38-38 Show publication in PURE
2012
Florian Krainer, Christian Dietzsch, Tanja Hajek, Christoph Herwig, Oliver Spadiut and Anton Glieder Recombinant protein expression in Pichia pastoris strains with an engineered methanol utilization pathway Show publication in TUGRAZonline
Jung Soh, Paul M. K. Gordon and Christoph Wilhelm Sensen Genome annotation [Elektronische Ressource]n/a978-1-439-84117-4 Show publication in TUGRAZonline
R. K. Lee, D. S. Hittel, V. Z. Nyamandi, L. Kang, Jung Soh, Christoph Wilhelm Sensen and J. Shearer Unconventional Microarray Design Reveals the Response to Obesity is Largely Tissue-Specific: Analysis of Common and Divergent Responses to Diet-Induced Obesity in Insulin Sensitive Tissues Show publication in TUGRAZonline
S. J. Fowler , Xiaoli Dong, Christoph Wilhelm Sensen, J. M. Suflita and Lisa M. Gieg Methanogenic toluene metabolism: community structure and intermediates Show publication in TUGRAZonline
Y. Kryachko , Xiaoli Dong, Christoph Wilhelm Sensen and Gerrit Voordouw Compositions of microbial communities associated with oil and water in a mesothermic oil field Show publication in TUGRAZonline
P. J. Facchini , J. Bohlmann , P. S. Covello, V. De Luca V, R. Mahadevan , J. E. Page, D. K. Ro, Christoph Wilhelm Sensen and R. Storms Synthetic biosystems for the production of high-value plant metabolites Show publication in TUGRAZonline
C. Berdugo-Clavijo , Xiaoli Dong, Jung Soh, Christoph Wilhelm Sensen and Lisa M. Gieg Methanogenic Biodegradation of Two-ringed Polycyclic Aromatic Hydrocarbons Show publication in TUGRAZonline
Jung Soh, Paul M. K. Gordon and Christoph Wilhelm Sensen The Bluejay Genome Browser Show publication in TUGRAZonline
Christoph Wilhelm Sensen, B. F. Benkel, Amanda Smith, Knud Christensen, Razvan Anistoroaei , Ye Zhang , Farid Hossain, Lyn Paterson and Ronald M. Teather A comparative, BAC end sequence enabled map of the genome of the American mink (Neovison vison) Show publication in TUGRAZonline
N. J. Ruecker, J. C. Matsune, D. R. Lapen, E. Topp, T. A. Edge, Christoph Wilhelm Sensen, L. Xiao and N. F. Neumann Molecular and phylogenetic approaches for assessing sources of Cryptosporidium contamination in water Show publication in TUGRAZonline
Christoph Wilhelm Sensen, Jung Soh and Paul M. K. Gordon Genome Annotationn/a978-1-4398-4117-4 Show publication in TUGRAZonline
Stefan Heinl, D Wibberg, F.G. Eikmeyer, R Szczepanowski , J Blom, B Linke, A Goesmann, Reingard Grabherr, Helmut Schwab, Alf Pühler and Andreas Schlüter Insights into the completely annotated genome of Lactobacillus buchneri CD034, a strain isolated from stable grass silage Show publication in TUGRAZonline
Tanja Knaus, Markus Schober, Bernhard Kepplinger, Martin Faccinelli, Julia Pitzer, Kurt Faber, Peter Macheroux and Ulrike Wagner Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates Show publication in TUGRAZonline
Christoph Sygmund, Alexander Gutmann, Iris Krondorfer, Magdalena Kujawa, Anton Glieder, Beate Pscheidt, Dietmar Haltrich, Clemens Peterbauer and Roman Kittl Simple and efficient expression of Agaricus meleagris pyranose dehydrogenase in Pichia pastoris Show publication in TUGRAZonline
Andreas Braun, Martina Geier, Bruno Buehler, Andreas Schmid, Stephan Mauersberger and Anton Glieder Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes Show publication in TUGRAZonline
Martina Geier, Andreas Braun, Anita Emmerstorfer, Harald Pichler and Anton Glieder Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study Show publication in TUGRAZonline
Kerstin Steiner and Helmut Schwab Recent advances in rational approaches for enzyme engineerings in rational approaches for enzyme engineering Show publication in TUGRAZonline
Margit Winkler and Andrea Camattari Recombinant Human Flavin Monooxygenases: Expression and Moclobemide N-oxide Synthesis on Semi-Preparative ScaleNew BiotechnologyS236 - S237 Show publication in TUGRAZonline
Katrin Weinhandl, Margit Winkler, Anton Glieder and Andrea Camattari A NOVEL MULTI-ENZYMATIC ASSAY FOR TRANSAMINASE ACTIVITY: HIGH THROUGHPUT SCREENING APPLICATIONS IN PICHIA PASTORIS Show publication in TUGRAZonline
Birgit Wilding, Margit Winkler, Regina Kratzer, Barbara Petschacher, Anton Glieder and Norbert Klempier NITRILE REDUCTASE FROM GEOBACILLUS KAUSTOPHILUS: A POTENTIAL CATALYST FOR A NEW NITRILE BIOTRANSFORMATION REACTION Show publication in TUGRAZonline
Enrique Herrero Acero, Doris Ribitsch, Katrin Julia Greimel, Anita Dellacher, Sabine Zitzenbacher, Annemarie Marold, Rosario Diaz Rodriguez, Gibson Stephen Nyanhongo, Helmut Schwab and Georg Gübitz Two-step enzymatic functionalisation of polyamide with phenolics Show publication in TUGRAZonline
Bettina Halwachs, Gregor Gorkiewicz and Gerhard Thallinger High-throughput characterization and comparison of microbial communitiesComputational Medicine37 - 57 Show publication in TUGRAZonline
Andreas Braun, Bettina Halwachs, Martina Geier, Katrin Weinhandl, Michael Guggemos, Jan Marienhagen, Anna Joel Ruff, Ulrich Schwaneberg, Daniel E. Torres Pazmiño, Vincent Rabin, Gerhard Thallinger and Anton Glieder MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes Show publication in TUGRAZonline
Christine Winkler Organaktivitäten im Schüttelkolben: Rekombinante menschliche Enzyme für die Pharmaindustrie Show publication in TUGRAZonline
Margit Winkler Organ Function in Shake Flasks: Recombinant Human Enzymes for the Pharmaceutical Industry Show publication in TUGRAZonline
Andrzej Lyskowski, Martin Tengg, Georg Steinkellner, Helmut Schwab, Mandana Gruber and Karl Gruber Crystallisation of the novel S-adenosyl-L-methionine dependent C-methyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data analysis. Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. Show publication in TUGRAZonline
Martin Tengg, Harald Stecher, Peter Remler, Inge Eiteljörg, Mandana Gruber and Helmut Schwab Molecular characterization of the C-Methyltransferase NovO of Streptomyces spheroides, a valuable enzyme for performing Friedel-Crafts alkylation Show publication in TUGRAZonline
Steven P. Hanlon, Andrea Camattari, Sandra Abad, Anton Glieder, Beat Wirz, Matthias Kittelmann, Stephan Lütz and Margit Winkler EXPRESSION OF RECOMBINANT HUMAN FLAVIN MONOOXYGENASE AND MOCLOBEMIDE N-OXIDE SYNTHESIS ON MULTI-MG SCALE Show publication in TUGRAZonline
Doris Ribitsch, Enrique Herrero Acero, Katrin Julia Greimel, Anita Dellacher, Sabine Zitzenbacher, Annemarie Marold, Rosario Diaz Rodriguez, Georg Steinkellner, Karl Gruber, Helmut Schwab and Georg Gübitz A New Esterase from Thermobifida halotolerans Hydrolyses Polyethylene Terephthalate (PET) and Polylactic Acid (PLA) Show publication in TUGRAZonline
Harald Pichler and Tamara Wriessnegger Pichia pastoris as whole-cell biocatalyst for (+)-nootkatone productionPichia 201248 - 48 Show publication in TUGRAZonline
Kerstin Steiner, Andrzej Franciszek Lyskowski, Ivan Hajnal, Georg Steinkellner, Helmut Schwab and Karl Gruber Crystallization of a novel metal-containing cupin from Acidobacterium sp. and preliminary diffraction data analysis Show publication in TUGRAZonline
Doris Ribitsch, Enrique Herrero Acero, Katrin Julia Greimel, Inge Eiteljörg, Eva Trotscha, Giuliano Freddi, Helmut Schwab and Georg Gübitz Characterization of a new cutinase from Thermobifida alba regarding PET-surface hydrolysis Show publication in TUGRAZonline
Zahid Hussain, Romana Wiedner, Kerstin Steiner, Tanja Hajek, Manuela Avi , Bianca Hecher, Angela Sessitsch and Helmut Schwab Characterization of two bacterial hydroxynitrile lyases with high similarity to cupin superfamily proteins Show publication in TUGRAZonline
Doris Ribitsch, Sonja Heumann, W. Karl, Jochen Gerlach, R. Leber, Ruth Birner-Grünberger, Karl Gruber, Inge Eiteljörg, Peter Remler, P. Siegert, J. Lange, Karl-Heinz Maurer, Gabriele Berg, Georg Gübitz and Helmut Schwab Extracellular serine proteases from Stenotrophomonas maltophilia: screening, isolation and heterologous expression in E.coli. Show publication in TUGRAZonline
Margit Winkler, Anton Glieder and Kerstin Steiner C–X Bond Formation: Hydroxynitrile lyases: From Nature to ApplicationComprehensive Chirality350 - 371 Show publication in TUGRAZonline
Margit Winkler and David O'Hagan Synthesis of Fluorinated Neurotransmitter AnaloguesFluorine in Pharmaceutical and Medicinal Chemistry : From Biophysical Aspects to Clinical Applications299 - 331 Show publication in TUGRAZonline
Peter J. Facchini, J. Bohlmann, P. S. Covello, V. De Luca V, R. Mahadevan, J. E. Page, D. K. Ro, Christoph Wilhelm Sensen and R. Storms Synthetic biosystems for the production of high-value plant metabolites Show publication in PURE
Andreas Braun, Bettina Halwachs, Martina Geier, Katrin Weinhandl, Michael Guggemos, Jan Marienhagen, Anna Joel Ruff, Ulrich Schwaneberg, Daniel E. Torres Pazmiño, Vincent Rabin, Gerhard Thallinger and Anton Glieder MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes Show publication in PURE
N. J. Ruecker, J. C. Matsune, D. R. Lapen, E. Topp, T. A. Edge, Christoph Wilhelm Sensen, L. Xiao and N. F. Neumann Molecular and phylogenetic approaches for assessing sources of Cryptosporidium contamination in water Show publication in PURE
Doris Ribitsch, Sonja Heumann, W. Karl, Jochen Gerlach, R. Leber, Ruth Birner-Grünberger, Karl Gruber, Inge Eiteljörg, Peter Remler, P. Siegert, J. Lange, Karl-Heinz Maurer, Gabriele Berg, Georg Gübitz and Helmut Schwab Extracellular serine proteases from Stenotrophomonas maltophilia: screening, isolation and heterologous expression in E.coli. Show publication in PURE
Martin Tengg, Harald Stecher, Peter Remler, Inge Eiteljörg, Mandana Gruber and Helmut Schwab Molecular characterization of the C-Methyltransferase NovO of Streptomyces spheroides, a valuable enzyme for performing Friedel-Crafts alkylation Show publication in PURE
Tanja Knaus, Markus Schober, Bernhard Kepplinger, Martin Faccinelli, Julia Pitzer, Kurt Faber, Peter Macheroux and Ulrike Wagner Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates Show publication in PURE
Zahid Hussain, Romana Wiedner, Kerstin Steiner, Tanja Hajek, Manuela Avi, Bianca Hecher, Angela Sessitsch and Helmut Schwab Characterization of two bacterial hydroxynitrile lyases with high similarity to cupin superfamily proteins Show publication in PURE
Margit Winkler Organ Function in Shake Flasks: Recombinant Human Enzymes for the Pharmaceutical Industry Show publication in PURE
Doris Ribitsch, Enrique Herrero Acero, Katrin Julia Greimel, Inge Eiteljörg, Eva Trotscha, Giuliano Freddi, Helmut Schwab and Georg Gübitz Characterization of a new cutinase from Thermobifida alba regarding PET-surface hydrolysis Show publication in PURE
Kerstin Steiner and Helmut Schwab Recent advances in rational approaches for enzyme engineerings in rational approaches for enzyme engineering Show publication in PURE
Jung Soh, Paul M. K. Gordon and Christoph Wilhelm Sensen Genome annotation [Elektronische Ressource] Show publication in PURE
Enrique Herrero Acero, Doris Ribitsch, Katrin Julia Greimel, Anita Dellacher, Sabine Zitzenbacher, Annemarie Marold, Rosario Diaz Rodriguez, Gibson Stephen Nyanhongo, Helmut Schwab and Georg Gübitz Two-step enzymatic functionalisation of polyamide with phenolics Show publication in PURE
Florian Krainer, Christian Dietzsch, Tanja Hajek, Christoph Herwig, Oliver Spadiut and Anton Glieder Recombinant protein expression in Pichia pastoris strains with an engineered methanol utilization pathway Show publication in PURE
S. J. Fowler, Xiaoli Dong, Christoph Wilhelm Sensen, J. M. Suflita and Lisa M. Gieg Methanogenic toluene metabolism: community structure and intermediates Show publication in PURE
Christoph Wilhelm Sensen, Jung Soh and Paul M. K. Gordon Genome Annotation Show publication in PURE
Stefan Heinl, D Wibberg, F.G. Eikmeyer, R Szczepanowski, J Blom, B Linke, A Goesmann, Reingard Grabherr, Helmut Schwab, Alf Pühler and Andreas Schlüter Insights into the completely annotated genome of Lactobacillus buchneri CD034, a strain isolated from stable grass silage Show publication in PURE
R. K. Lee, D. S. Hittel, V. Z. Nyamandi, L. Kang, Jung Soh, Christoph Wilhelm Sensen and J. Shearer Unconventional Microarray Design Reveals the Response to Obesity is Largely Tissue-Specific: Analysis of Common and Divergent Responses to Diet-Induced Obesity in Insulin Sensitive Tissues Show publication in PURE
Christoph Sygmund, Alexander Gutmann, Iris Krondorfer, Magdalena Kujawa, Anton Glieder, Beate Pscheidt, Dietmar Haltrich, Clemens Peterbauer and Roman Kittl Simple and efficient expression of Agaricus meleagris pyranose dehydrogenase in Pichia pastoris Show publication in PURE
Christine Winkler Organaktivitäten im Schüttelkolben: Rekombinante menschliche Enzyme für die Pharmaindustrie Show publication in PURE
Kerstin Steiner, Andrzej Franciszek Lyskowski, Ivan Hajnal, Georg Steinkellner, Helmut Schwab and Karl Gruber Crystallization of a novel metal-containing cupin from Acidobacterium sp. and preliminary diffraction data analysis Show publication in PURE
Christoph Wilhelm Sensen, B. F. Benkel, Amanda Smith, Knud Christensen, Razvan Anistoroaei, Ye Zhang, Farid Hossain, Lyn Paterson and Ronald M. Teather A comparative, BAC end sequence enabled map of the genome of the American mink (Neovison vison) Show publication in PURE
Y. Kryachko, Xiaoli Dong, Christoph Wilhelm Sensen and Gerrit Voordouw Compositions of microbial communities associated with oil and water in a mesothermic oil field Show publication in PURE
Jessica Rehdorf, Geoffrey A Behrens, Giang-Son Nguyen, Robert Kourist and Uwe T Bornscheuer Pseudomonas putida esterase contains a GGG(A)X-motif confering activity for the kinetic resolution of tertiary alcohols Show publication in PURE
Henrike B Brundiek, Andrew S Evitt, Robert Kourist and Uwe T Bornscheuer Creation of a lipase highly selective for trans fatty acids by protein engineering Show publication in PURE
Martina Geier, Andreas Braun, Anita Emmerstorfer, Harald Pichler and Anton Glieder Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study Show publication in PURE
Katrin Weinhandl, Margit Winkler, Anton Glieder and Andrea Camattari A NOVEL MULTI-ENZYMATIC ASSAY FOR TRANSAMINASE ACTIVITY: HIGH THROUGHPUT SCREENING APPLICATIONS IN PICHIA PASTORIS Show publication in PURE
Henrike Brundiek, Stefan Saß, Andrew Evitt, Robert Kourist and Uwe T Bornscheuer The short form of the recombinant CAL-A-type lipase UM03410 from the smut fungus Ustilago maydis exhibits an inherent trans-fatty acid selectivity Show publication in PURE
Andrzej Lyskowski, Martin Tengg, Georg Steinkellner, Helmut Schwab, Mandana Gruber and Karl Gruber Crystallisation of the novel S-adenosyl-L-methionine dependent C-methyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data analysis. Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. Show publication in PURE
Birgit Wilding, Margit Winkler, Regina Kratzer, Barbara Petschacher, Anton Glieder and Norbert Klempier NITRILE REDUCTASE FROM GEOBACILLUS KAUSTOPHILUS: A POTENTIAL CATALYST FOR A NEW NITRILE BIOTRANSFORMATION REACTION Show publication in PURE
Doris Ribitsch, Enrique Herrero Acero, Katrin Julia Greimel, Anita Dellacher, Sabine Zitzenbacher, Annemarie Marold, Rosario Diaz Rodriguez, Georg Steinkellner, Karl Gruber, Helmut Schwab and Georg Gübitz A New Esterase from Thermobifida halotolerans Hydrolyses Polyethylene Terephthalate (PET) and Polylactic Acid (PLA) Show publication in PURE
Jung Soh, Paul M. K. Gordon and Christoph Wilhelm Sensen The Bluejay Genome Browser Show publication in PURE
Margit Winkler, Anton Glieder and Kerstin Steiner C–X Bond Formation: Hydroxynitrile lyases: From Nature to ApplicationComprehensive Chirality350-371 Show publication in PURE
Steven P. Hanlon, Andrea Camattari, Sandra Abad, Anton Glieder, Beat Wirz, Matthias Kittelmann, Stephan Lütz and Margit Winkler Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale Show publication in PURE
Andreas Braun, Martina Geier, Bruno Buehler, Andreas Schmid, Stephan Mauersberger and Anton Glieder Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes Show publication in PURE
Margit Winkler and David O'Hagan Synthesis of Fluorinated Neurotransmitter AnaloguesFluorine in Pharmaceutical and Medicinal Chemistry : From Biophysical Aspects to Clinical Applications299-331 Show publication in PURE
Bettina Halwachs, Gregor Gorkiewicz and Gerhard Thallinger High-throughput characterization and comparison of microbial communitiesComputational Medicine37-57 Show publication in PURE
Andrea Mellitzer, Anton Glieder, Roland Weis, Christoph Reisinger and Karlheinz Flicker Sensitive high-throughput screening for the detection of reducing sugars Show publication in PURE
Margit Winkler and Andrea Camattari Recombinant Human Flavin Monooxygenases: Expression and Moclobemide N-oxide Synthesis on Semi-Preparative ScaleNew BiotechnologyS236-S237 Show publication in PURE
Andrea Mellitzer, Roland Weis, Anton Glieder and Karlheinz Flicker Expression of lignocellulolytic enzymes in Pichia pastoris Show publication in PURE
Laura Näätsaari, Beate Mistlberger, Claudia Ruth, Tanja Hajek, Franz Stefan Hartner and Anton Glieder Deletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biology Show publication in PURE
Harald Pichler and Tamara Wriessnegger Pichia pastoris as whole-cell biocatalyst for (+)-nootkatone productionPichia 201248-48 Show publication in PURE
C. Berdugo-Clavijo, Xiaoli Dong, Jung Soh, Christoph Wilhelm Sensen and Lisa M. Gieg Methanogenic Biodegradation of Two-ringed Polycyclic Aromatic Hydrocarbons Show publication in PURE
2011
Petra Köfinger, Christian Wels, Shiprad Joshi, Sabine Damm, Elisabeth Steinbauer, Christine Beham-Schmid, Sasa Frank, Helmut Bergler and Helmut Schaider The cadherin switch in melanoma instigated by HGF is mediated through epithelial-mesenchymal transition regulators. Show publication in TUGRAZonline
Christian Wels, Shiprad Joshi, Petra Köfinger, Helmut Bergler and Helmut Schaider Transcriptional Activation of ZEB1 by Slug Leads to Cooperative Regulation of the EMT like Phenotype in Melanoma Show publication in TUGRAZonline
Esther Ramos-Padron, Sylvain Bordenave, Shiping Lin, Iyswarya Mani Bhaskar , Christoph Wilhelm Sensen, Xiaoli Dong, Joseph Fournier, Gerrit Voordouw and Lisa M. Gieg Carbon and Sulfur Cycling by Microbial Communities in a Gypsum-Treated Oil Sands Tailings Pond Show publication in TUGRAZonline
Davin Duggan, D. S. Hittel, Christoph Wilhelm Sensen, Aalim M Weljie, Hans J. Vogel and J. Shearer Metabolomic Response to Exercise in Lean and Diet-induced Insulin Resistant Mice Show publication in TUGRAZonline
O. Meruvia-Pastor , M. Xiao , Jung Soh and Christoph Wilhelm Sensen Generation of connectivity-preserving surface models of multiple sclerosis lesionsMedicine meets virtual reality 18359 - 356 Show publication in TUGRAZonline
Cameron M. Callbeck, Xiaoli Dong, Indranil Chatterjee, Akhil Agrawal, Sean Caffrey, Christoph Wilhelm Sensen and Gerrit Voordouw Microbial community succession in a bioreactor modelling a souring low temperature oil reservoir subjected to nitrate injection Show publication in TUGRAZonline
O. Meruvia-Pastor , Jung Soh, J. E. Schmidt, J. C. Boughner , M. Xiao , H. A. Jamniczky , Benedikt Hallgrímsson and Christoph Wilhelm Sensen Estimating Cell Count and Distribution in Labeled Histological Samples Using Incremental Cell Search Show publication in TUGRAZonline
Jung Soh, M. Xiao , T. Do, O. Meruvia-Pastor and Christoph Wilhelm Sensen Integrative Visualization of Temporally Varying Medical Image Patterns Show publication in TUGRAZonline
Hyung Soo Park, Indranil Chatterjee, Xiaoli Dong, Sheng-Hung Wang, Christoph Wilhelm Sensen, Sean Caffrey, Thomas R. Jack, Joe Boivin and Gerrit Voordouw Effect of sodium bisulfite injection on the microbial community composition in failed pipe sections of a brackish-water-transporting pipeline Show publication in TUGRAZonline
Johan Wolfaardt, Ben King, Richard Bibb, Henk Verdonck, Jan de Cubber, Christoph Wilhelm Sensen and Jung Soh Digital Technology in Maxillofacial Rehabilitation.Maxillofacial Rehabilitation: Surgical and Prosthodontic Management of Cancer-Related Acquired, and Congenital Defects of the Head and Neck355 - 373 Show publication in TUGRAZonline
Enrique Herrero Acero, Doris Ribitsch, Georg Steinkellner, Karl Gruber , Katrin Julia Greimel, Inge Eiteljörg, Eva Trotscha, R. Wei, W. Zimmermann, M. Zinn, A. Cavaco-Paulo, G. Freddi, Helmut Schwab and Georg Gübitz Enzymatic Surface Hydrolysis of PET. Effect of Structural Diversity on Kinetic Properties of Cutinases from Thermobifida Show publication in TUGRAZonline
Doris Ribitsch, Sonja Heumann, Eva Trotscha, Enrique Herrero Acero, Katrin Julia Greimel, Inge Eiteljörg, Peter Remler, Regina Maria Leber, Sigrid Deller, Giuliano Freddi, I. Donelli, K.H. Maurer, P. Siegert, T. Weber, Helmut Schwab and Georg Gübitz Hydrolysis of polyethyleneterephthalate by para-nitrobenzylesterase from Bacillus subtilis Show publication in TUGRAZonline
Andrea Hasmann, Anita Eberl, Konstantin Schneider, K.-U. Schoening, F. Kaufmann, Anton Glieder, J. Kovac, Artur Cavaco-Paulo, Eva Wehrschütz-Sigl and Georg Gübitz Hydroxylation of polypropylene using the monooxygenase mutant 139-3 from Bacillus megaterium BM3 Show publication in TUGRAZonline
Cleiton M Souza, Tatjana M Schwabe, Harald Pichler, Birgit Ploier, Erich Leitner, Xue Li Guan, Markus W Wenk, Isabelle Riezman and Howard Riezman A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance Show publication in TUGRAZonline
Gernot Strohmeier, Harald Pichler, Oliver May and Mandana Gruber Application of Designed Enzymes in Organic Synthesis Show publication in TUGRAZonline
Andreas Küberl, Jessica Schneider, Gerhard Thallinger, Ingund Anderl, Daniel Wibberg, Tanja Hajek, Sebastian Jaenicke, Karina Brinkrolf, Alexander Goesmann, Rafael Szczepanowski, Alfred Pühler, Helmut Schwab, Anton Glieder and Harald Pichler High-quality genome sequence of Pichia pastoris CBS7435 Show publication in TUGRAZonline
Sandra Abad, Jozef Nahalka, Margit Winkler, Gabriele Bergler, Robert Speight, Anton Glieder and Bernd Nidetzky HIGH LEVEL EXPRESSION OF RHODOTORULA GRACILIS D-AMINO ACID OXIDASE IN PICHIA PASTORIS Show publication in TUGRAZonline
Matthias Schittmayer, Anton Glieder, Michael Karl Uhl, Andreas Winkler, Simone Zach, Jörg Schrittwieser, Wolfgang Kroutil, Peter Macheroux, Karl Gruber, Spiros Kambourakis, J. David Rozzell and Margit Winkler Old Yellow Enzyme catalyzed dehydrogenation of saturated ketones Show publication in TUGRAZonline
Gernot Strohmeier, Harald Pichler, Oliver May and Mandana Gruber Application of Designed Enzymes in Organic Synthesis Show publication in PURE
Cleiton M Souza, Tatjana M Schwabe, Harald Pichler, Birgit Ploier, Erich Leitner, Xue Li Guan, Markus W Wenk, Isabelle Riezman and Howard Riezman A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance Show publication in PURE
Petra Köfinger, Christian Wels, Shiprad Joshi, Sabine Damm, Elisabeth Steinbauer, Christine Beham-Schmid, Sasa Frank, Helmut Bergler and Helmut Schaider The cadherin switch in melanoma instigated by HGF is mediated through epithelial-mesenchymal transition regulators. Show publication in PURE
O. Meruvia-Pastor, Jung Soh, J. E. Schmidt, J. C. Boughner, M. Xiao, H. A. Jamniczky, Benedikt Hallgrímsson and Christoph Wilhelm Sensen Estimating Cell Count and Distribution in Labeled Histological Samples Using Incremental Cell Search Show publication in PURE
Doris Ribitsch, Sonja Heumann, Eva Trotscha, Enrique Herrero Acero, Katrin Julia Greimel, Inge Eiteljörg, Peter Remler, Regina Maria Leber, Sigrid Deller, Giuliano Freddi, I. Donelli, K.H. Maurer, P. Siegert, T. Weber, Helmut Schwab and Georg Gübitz Hydrolysis of polyethyleneterephthalate by para-nitrobenzylesterase from Bacillus subtilis Show publication in PURE
Andreas Küberl, Jessica Schneider, Gerhard Thallinger, Ingund Anderl, Daniel Wibberg, Tanja Hajek, Sebastian Jaenicke, Karina Brinkrolf, Alexander Goesmann, Rafael Szczepanowski, Alfred Pühler, Helmut Schwab, Anton Glieder and Harald Pichler High-quality genome sequence of Pichia pastoris CBS7435 Show publication in PURE
Sandra Abad, Jozef Nahalka, Margit Winkler, Gabriele Bergler, Robert Speight, Anton Glieder and Bernd Nidetzky HIGH LEVEL EXPRESSION OF RHODOTORULA GRACILIS D-AMINO ACID OXIDASE IN PICHIA PASTORIS Show publication in PURE
Davin Duggan, D. S. Hittel, Christoph Wilhelm Sensen, Aalim M Weljie, Hans J. Vogel and J. Shearer Metabolomic Response to Exercise in Lean and Diet-induced Insulin Resistant Mice Show publication in PURE
Hyung Soo Park, Indranil Chatterjee, Xiaoli Dong, Sheng-Hung Wang, Christoph Wilhelm Sensen, Sean Caffrey, Thomas R. Jack, Joe Boivin and Gerrit Voordouw Effect of sodium bisulfite injection on the microbial community composition in failed pipe sections of a brackish-water-transporting pipeline Show publication in PURE
Christian Wels, Shiprad Joshi, Petra Köfinger, Helmut Bergler and Helmut Schaider Transcriptional Activation of ZEB1 by Slug Leads to Cooperative Regulation of the EMT like Phenotype in Melanoma Show publication in PURE
Cameron M. Callbeck, Xiaoli Dong, Indranil Chatterjee, Akhil Agrawal, Sean Caffrey, Christoph Wilhelm Sensen and Gerrit Voordouw Microbial community succession in a bioreactor modelling a souring low temperature oil reservoir subjected to nitrate injection Show publication in PURE
Jung Soh, M. Xiao, T. Do, O. Meruvia-Pastor and Christoph Wilhelm Sensen Integrative Visualization of Temporally Varying Medical Image Patterns Show publication in PURE
Giang-Son Nguyen, Mark L. Thompson, Gideon Grogan, Uwe T. Bornscheuer and Robert Kourist Identification of novel esterases for the synthesis of sterically demanding chiral alcohols by sequence-structure guided genome mining Show publication in PURE
Yusuke Miyauchi, Robert Kourist, Daisuke Uemura and Kenji Miyamoto Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by structure-guided directed evolution. Show publication in PURE
R Kourist and K.‚ Miyamoto Protein engineering of arylmalonate decarboxylase G74C, an artificial racemase Show publication in PURE
Robert Kourist, Pablo Domínguez de María and Kenji Miyamoto Biocatalytic strategies for the asymmetric synthesis of profens – recent trends and developments Show publication in PURE
R Kourist and U T Bornscheuer Biocatalytic synthesis of optically active tertiary alcohols Show publication in PURE
Susanne Herter, Giang-Son Nguyen, Mark L Thompson, Fabian Steffen-Munsberg, Frieder Schauer, Uwe T Bornscheuer and Robert Kourist Comparative analysis of tertiary alcohol esterase activity in bacterial strains isolated from enrichment cultures and from screening strain libraries. Show publication in PURE
Andrea Hasmann, Anita Eberl, Konstantin Schneider, K.-U. Schoening, F. Kaufmann, Anton Glieder, J. Kovac, Artur Cavaco-Paulo, Eva Wehrschütz-Sigl and Georg Gübitz Hydroxylation of polypropylene using the monooxygenase mutant 139-3 from Bacillus megaterium BM3 Show publication in PURE
Johan Wolfaardt, Ben King, Richard Bibb, Henk Verdonck, Jan de Cubber, Christoph Wilhelm Sensen and Jung Soh Digital Technology in Maxillofacial Rehabilitation.Maxillofacial Rehabilitation: Surgical and Prosthodontic Management of Cancer-Related Acquired, and Congenital Defects of the Head and Neck355-373 Show publication in PURE
Karim Engelmark Cassimjee, Robert Kourist, Diana Lindberg, Marianne Wittrup Larsen, Nguyen Hong Thanh, Mikael Widersten, Uwe T Bornscheuer and Per Berglund One-step enzyme extraction and immobilization for biocatalysis applications. Show publication in PURE
Matthias Schittmayer, Anton Glieder, Michael Karl Uhl, Andreas Winkler, Simone Zach, Jörg Schrittwieser, Wolfgang Kroutil, Peter Macheroux, Karl Gruber, Spiros Kambourakis, J. David Rozzell and Margit Winkler Old Yellow Enzyme catalyzed dehydrogenation of saturated ketones Show publication in PURE
Enrique Herrero Acero, Doris Ribitsch, Georg Steinkellner, Karl Gruber, Katrin Julia Greimel, Inge Eiteljörg, Eva Trotscha, R. Wei, W. Zimmermann, M. Zinn, A. Cavaco-Paulo, G. Freddi, Helmut Schwab and Georg Gübitz Enzymatic Surface Hydrolysis of PET. Effect of Structural Diversity on Kinetic Properties of Cutinases from Thermobifida Show publication in PURE
O. Meruvia-Pastor, M. Xiao, Jung Soh and Christoph Wilhelm Sensen Generation of connectivity-preserving surface models of multiple sclerosis lesionsMedicine meets virtual reality 18359-356 Show publication in PURE
Esther Ramos-Padron, Sylvain Bordenave, Shiping Lin, Iyswarya Mani Bhaskar, Christoph Wilhelm Sensen, Xiaoli Dong, Joseph Fournier, Gerrit Voordouw and Lisa M. Gieg Carbon and Sulfur Cycling by Microbial Communities in a Gypsum-Treated Oil Sands Tailings Pond Show publication in PURE
2010
Sabine Damm, Petra Köfinger, Martina Stefan, Christian Wels, Gabor Mehes, Eva Richtig, Helmut Kerl, Marcus Otte and Helmut Schaider HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta Show publication in TUGRAZonline
Mei Xiao, Jung Soh, O. Meruvia-Pastor , Eric J. Schmidt, Benedikt Hallgrímsson and Christoph Wilhelm Sensen Building Generic Anatomical Models Using Virtual Model Cutting and Iterative Registration Show publication in TUGRAZonline
Jonathan Zuccolo, Jeremy Bau, Sarah J. Childs, Christoph Wilhelm Sensen, Greg G. Goss and Julie P. Deans Phylogenetic Analysis of the MS4A and TMEM176 Gene Families Show publication in TUGRAZonline
Eric J. Schmidt, Trish E. Parsons, Heather A. Jamniczky , Julian Gitelman, Cvett Trpkov, Julia C. Boughner , C. Cairine Logan, Christoph Wilhelm Sensen and Benedikt Hallgrímsson Micro-computed tomography-based phenotypic approaches in embryology: Sources and effects of procedural artifacts on assessments of embryonic craniofacial growth and development Show publication in TUGRAZonline
Bernd Nidetzky, Sandra Abad, Jozef Nahalka, Robert Speight, I. Fotheringhan and Anton Glieder Stepwise engineering of a Pichia pastoris D-amino acid whole cell catalyst Show publication in TUGRAZonline
Doris Ribitsch, W Karl, Ruth Birner-Grünberger, Karl Gruber, Inge Eiteljörg, Peter Remler, Susanne Wieland, Petra Siegert, Karl Maurer and Helmut Schwab Engineering of choline oxidase from Arthrobacter nicotianae for potential use as biological bleach in detergents. Show publication in TUGRAZonline
Doris Ribitsch, W Karl, Ruth Birner-Grünberger, Karl Gruber, Inge Eiteljörg, Peter Remler, Susanne Wieland, Petra Siegert, Karl Maurer and Helmut Schwab C-terminal truncation of a metagenome-derived detergent protease for effective expression in E. coli. Show publication in TUGRAZonline
Ulrike Schreiner, Bianca Hecher, Sascha Obrowsky, Kerstin Waich, Norbert Klempier, Georg Steinkellner , Karl Gruber, J. David Rozzell, Anton Glieder and Margit Winkler Directed evolution of Alcaligenes faecalis nitrilase Show publication in TUGRAZonline
Claudia Ruth and Anton Glieder Perspectives on synthetic promoters for biocatalysis and biotransformation Show publication in TUGRAZonline
Sandra Abad, Kerstin Kitz, Astrid Hörmann, Ulrike Schreiner, Franz Stefan Hartner and Anton Glieder Real time PCR based determination of gene copy numbers in Pichia pastoris Show publication in TUGRAZonline
Daniel E Torres Pazmiño, Margit Winkler, Anton Glieder and Marco W Fraaije Monooxygenases as biocatalysts: classification, mechanistic aspects and biotechnological applications Show publication in TUGRAZonline
Kirsten Schroer, Klaus Peter Luef, Franz Stefan Hartner, Anton Glieder and Beate Pscheidt Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation Show publication in TUGRAZonline
Ulrike Schreiner, Georg Steinkellner, Anton Glieder, J. David Rozzell and Margit Winkler IMPROVED FITNESS OF ARABIDOPSIS THALIANA NITRILASE 2 Show publication in TUGRAZonline
Martin Koller, Aid Atlic, Miguel Miranda de Sousa Dias, Angelika Reiterer and Gerhart Braunegg Microbial PHA Production from Waste Raw MaterialsPlastics from Bacteria: Natural Functions and Applications85 - 119 Show publication in TUGRAZonline
Ulrike Schreiner, Bianca Hecher, Sascha Obrowsky, Kerstin Waich, Norbert Klempier, Georg Steinkellner, Karl Gruber, J. David Rozzell, Anton Glieder and Margit Winkler Directed evolution of Alcaligenes faecalis nitrilase Show publication in PURE
Jonathan Zuccolo, Jeremy Bau, Sarah J. Childs, Christoph Wilhelm Sensen, Greg G. Goss and Julie P. Deans Phylogenetic Analysis of the MS4A and TMEM176 Gene Families Show publication in PURE
Sandra Abad, Kerstin Kitz, Astrid Hörmann, Ulrike Schreiner, Franz Stefan Hartner and Anton Glieder Real time PCR based determination of gene copy numbers in Pichia pastoris Show publication in PURE
Doris Ribitsch, W Karl, Ruth Birner-Grünberger, Karl Gruber, Inge Eiteljörg, Peter Remler, Susanne Wieland, Petra Siegert, Karl Maurer and Helmut Schwab Engineering of choline oxidase from Arthrobacter nicotianae for potential use as biological bleach in detergents. Show publication in PURE
Kirsten Schroer, Klaus Peter Luef, Franz Stefan Hartner, Anton Glieder and Beate Pscheidt Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation Show publication in PURE
Martin Koller, Aid Atlic, Miguel Miranda de Sousa Dias, Angelika Reiterer and Gerhart Braunegg Microbial PHA Production from Waste Raw MaterialsPlastics from Bacteria: Natural Functions and Applications85-119 Show publication in PURE
Daniel E Torres Pazmiño, Margit Winkler, Anton Glieder and Marco W Fraaije Monooxygenases as biocatalysts: classification, mechanistic aspects and biotechnological applications Show publication in PURE
Doris Ribitsch, W Karl, Ruth Birner-Grünberger, Karl Gruber, Inge Eiteljörg, Peter Remler, Susanne Wieland, Petra Siegert, Karl Maurer and Helmut Schwab C-terminal truncation of a metagenome-derived detergent protease for effective expression in E. coli. Show publication in PURE
Claudia Ruth and Anton Glieder Perspectives on synthetic promoters for biocatalysis and biotransformation Show publication in PURE
Matthias Theurer, Peter Fischer, Angelika Baro, Giang Son Nguyen, Robert Kourist, Uwe Bornscheuer and Sabine Laschat Formation of chiral tertiary homoallylic alcohols via Evans aldol reaction or enzymatic resolution and their influence on the Sharpless asymmetric dihydroxylation Show publication in PURE
Ulrike Schreiner, Georg Steinkellner, Anton Glieder, J. David Rozzell and Margit Winkler IMPROVED FITNESS OF ARABIDOPSIS THALIANA NITRILASE 2 Show publication in PURE
Giang-Son Nguyen, Robert Kourist, Monica Paravidino, Anke Hummel, Jessica Rehdorf, Romano V. a. Orru, Ulf Hanefeld and Uwe T. Bornscheuer An Enzymatic Toolbox for the Kinetic Resolution of 2-(Pyridin- x -yl)but-3-yn-2-ols and Tertiary Cyanohydrins Show publication in PURE
R Kourist, H Jochens, S Bartsch, R Kuipers, S K Padhi, M Gall, D Böttcher, H J Joosten and U T Bornscheuer The alpha/beta-hydrolase fold 3DM database (ABHDB) as a tool for protein engineering Show publication in PURE
Robert Kourist, Henrike Brundiek and Uwe T. Bornscheuer Protein engineering and discovery of lipases Show publication in PURE
M Gall, R Kourist, M Schmidt and U T Bornscheuer The role of the GGGX motif in determining the activity and enantioselectivity of pig liver esterase towards tertiary alcohols Show publication in PURE
Elena Fernández-Álvaro, Robert Kourist, Julia Winter, Dominique Böttcher, Klaus Liebeton, Christian Naumer, Jürgen Eck, Christian Leggewie, Karl-Erich Jaeger, Wolfgang Streit and Uwe T Bornscheuer Enantioselective kinetic resolution of phenylalkyl carboxylic acids using metagenome-derived esterases. Show publication in PURE
Sabine Damm, Petra Köfinger, Martina Stefan, Christian Wels, Gabor Mehes, Eva Richtig, Helmut Kerl, Marcus Otte and Helmut Schaider HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta Show publication in PURE
Bernd Nidetzky, Sandra Abad, Jozef Nahalka, Robert Speight, I. Fotheringhan and Anton Glieder Stepwise engineering of a Pichia pastoris D-amino acid whole cell catalyst Show publication in PURE
Mei Xiao, Jung Soh, O. Meruvia-Pastor, Eric J. Schmidt, Benedikt Hallgrímsson and Christoph Wilhelm Sensen Building Generic Anatomical Models Using Virtual Model Cutting and Iterative Registration Show publication in PURE
Eric J. Schmidt, Trish E. Parsons, Heather A. Jamniczky, Julian Gitelman, Cvett Trpkov, Julia C. Boughner, C. Cairine Logan, Christoph Wilhelm Sensen and Benedikt Hallgrímsson Micro-computed tomography-based phenotypic approaches in embryology: Sources and effects of procedural artifacts on assessments of embryonic craniofacial growth and development Show publication in PURE

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Team Leader
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Harald Pichler
Assoc.Prof. Dipl.-Ing. Dr.techn.