Optical imaging of concrete materials: Application and synthesis of luminescent pH sensitive dyes with high pKa values as well as chloride sensitive dyes for monitoring of degradation processes of concrete materials.
Optical Sensor Concepts for Monitoring Metabolic Activity: Investigation of new sensor concepts for lactate, potassium and reactive oxygen species, and transfer to Organ-on-Chips devices. Sensor concepts are based on the enzyme catalysed conversion of the target analytes and the determination of consumed oxygen or changes of pH by integrated optical sensors.
Thermally Activated Delayed Fluorescence-based Molecular Thermometers: Design, synthesis and characterisation of new purely organic and metal-organic thermally activated delayed fluorescent (TADF) emitters. Development of applications for molecular thermometers based on TADF dyes
Optical biosensor integration in microfluidic systems: Development of optical measurement systems for toxicity tests of nanomaterials based an algae-biosensors. Application of bioprinting methods to integrate algae based biosensors in microfluidic devices.
Porous materials for optical sensing of methane: Synthesis of porous materials (MOFs, MIPs, Sol Gels,...). Investigation of the materials regarding their stability, structure and gas uptake. Synthesis of fluorescent/phosphorescent dyes as indicators for optical sensing. Combination of the porous materials with the indicator dyes and investigation of their methane sensing behaviour.
Optical pH sensitive materials for biotechnological and life science applications: Preparation of pH sensor systems for water/solvent mixtures based on solvent resistant matrices. Application of pH-sensitive materials for the detection of ammonia or amines in bioprocesses.
Integration of optical sensors in microphysiological systems (Organ-on-Chip): Miniaturization and integration of oxygen and pH sensors in various microfluidic systems for cell culture (Organ-on-Chip (OoC)). Adaptation of glucose sensor for use in OoC (measurement range, biocompatibility, size). Multiparametric monitoring of cells in OoC.
Synthesis and characterization of BODIPY dyes: with different receptors for the detection of biologically relevant reactive species including organophosphorus nerve agents, H2S, H2O2 and 1O2. The probes are incorporated into polymeric matrices to prepare optical chemodosimeters for practical application in different scientific fields.
Electrospun Hydrogel Micro- and Nanofibers: Preparation of micro-and nanofibers via electrospinning, characterization of fibers and application for example in fast responding humidity sensors. Development of new procedures for electrospinning of hydrogels and related materials.
Porphyrin-based Metal-Organic Frameworks: Synthesis and characterization of porphyrins for oxygen sensor materials. Crystallization of porphyrins and inorganic linkers towards high resilient porous oxygen sensor materials.
For information on possible topics for Bachelor- / Masterthesis please contact us by phone or email (Dr. Helmar Wiltsche) or visit us at our institute.
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