Optical imaging of concrete materials: Application and synthesis of luminescent pH sensitive dyes with high pKa values as well as chloride sensitive dyes for monitoring of degradation processes of concrete materials.
Optical Sensor Concepts for Monitoring Metabolic Activity: Investigation of new sensor concepts for lactate, potassium and reactive oxygen species, and transfer to Organ-on-Chips devices. Sensor concepts are based on the enzyme catalysed conversion of the target analytes and the determination of consumed oxygen or changes of pH by integrated optical sensors.
Thermally Activated Delayed Fluorescence-based Molecular Thermometers: Design, synthesis and characterisation of new purely organic and metal-organic thermally activated delayed fluorescent (TADF) emitters. Development of applications for molecular thermometers based on TADF dyes
Synthesis and Characterisation of Optical Trace Ammonia Sensors and Luminescence Based CO2 Sensors: Design, synthesis and characterisation of asymmetric BF2-chelated tetraarylazadipyrromethene (azaBODIPY) dyes for environmental monitoring of trace amounts of ammonia in waters and application as CO2 sensors in Organ-On-Chip (OoC) systems.
Optical biosensor integration in microfluidic systems: Development of optical measurement systems for toxicity tests of nanomaterials based an algae-biosensors. Application of bioprinting methods to integrate algae based biosensors in microfluidic devices.
Porphyrin based indicators for dual oxygen and temperature sensing: Synthesis and photophysical characterization of porphyrin based luminescent indicators exhibiting simultaneous phosphorescence and thermally activated delayed fluorescence at ambient temperatures. Preparation and evaluation of sensor materials based on these dyes.
Hydrophilic fluorescent conjugated polymers for optical sensing of pH/ions: Preparation of hydrophilic conjugated fluorescent polymers containing additional functionalities for sensing pH/ions. These materials will be evaluated in form of bulk optodes and water-dispersible nanoparticles, particularly for imaging applications with help of multi-photon excitation.
Label-free optical immunosensor for biomarker detection: Development of a Mach-Zehnder interferometer based platform for the detection of clinically relevant biomarkers, e.g. proinflammatory cytokines. Investigation of: various antibody immobilization techniques, methods of unspecific adsorption reduction and the binding efficiency of biomarkers.
Optical Imaging of Concrete – Chloride Sensitive Imaging: Synthesis and study of chloride sensitive dyes for (DLR) imaging; also, applying fluorescence imaging for pH and chloride resolution in concrete material surfaces. Furthermore, fluorescence imaging will be extended to more applications, for example for depth profile analysis.
Integration of optical sensors in microphysiological systems (Organ-on-Chip): Miniaturization and integration of oxygen and pH sensors in various microfluidic systems for cell culture (Organ-on-Chip (OoC)). Adaptation of glucose sensor for use in OoC (measurement range, biocompatibility, size). Multiparametric monitoring of cells in OoC.
For information on possible topics for Bachelor- / Masterthesis please contact us by phone or email (Dr. Helmar Wiltsche) or visit us at our institute.