Time calibration of a thrombus formation model for an idealized backward-facing step geometry

Aortic Dissection (AD) is a severe condition that involves the aorta. Although the number of cases that have been registered is relatively small, this illness is often fatal. Blood clot, medically thrombus, is a coagulation of blood that forms under some particular conditions. When formed and then dislodged, the thrombus can be dangerous or fatal. However, the thrombus can be clinically beneficial in AD when it develops in the FL. A thrombus formation model is developed following Menichini et al.

The model has been performed in 2D backward-facing step (BFS) settings. The model is a hemodynamic-based model in which the thrombus forms and grows mainly in areas where low shear stress and high residence time are measured. Experimental results of thrombus growth in a 3D BFS are available from Joshua O Taylor et al. The experimental results and the computational model coincide in trend. However, they act on two different time scales: the thrombus develops in circa 30 minutes in the experiment, while the model is much faster.

Aim: The Master Thesis aims to find the settings to create a time calibration algorithm between experimental data and computational model. Furthermore, the use of sensitivity analysis is suggested to reach such a goal.


•    Literature research of time calibration of models to data
•    development of an algorithm. MATLAB language is preferred but not mandatory

Scientific publication is possible at the end of the thesis.

Duration: 3 to 6 months

Begin: as soon as possible

Requirements: Basic knowledge of any coding language

For any information, please contact Melito Gian Marco gmelitonoSpam@tugraz.at