At first glance, this type of high-rise building appears to be inherently energy efficient. However, the wind pressure prevailing at high altitudes often makes the use of conventional external sun shading devices and openable windows impossible, so that year-round mechanical ventilation and air conditioning systems are usually used. Strategies that allow natural ventilation of tall buildings therefore have a high potential for improving energy efficiency. For this reason, the winning project in the competition for the new headquarters of the European Central Bank in Frankfurt developed a concept that allows exclusively natural ventilation of the building. These ideas were further developed within the framework of the present research project. The following advantages can result from this: Higher energy efficiency in operation, reduction of grey energy, lower risk of Sick Building Syndrome, savings in both operating costs and construction costs. The results were presented to the scientific community at an international congress in Kyoto, Japan in October 2008.