Cohesive particulate matter is of central importance for chemical engineering, as well as a plurality of other sciences, e.g., space or earth sciences that are interested in the mechanical properties of particulate systems. While a variety of particle-scale models for cohesive systems are available (e.g., models for van der Waals forces), the effect of model details on bulk properties (e.g., the yield locus, or the bulk density) are not well explored. Also, most available force models were built for infinitely stiff particles. This image of infinitely stiff particles conflicts with the assumption of Discrete Element Method (DEM)-based simulators that rely on (often very) soft particles.
We are looking for two enthusiastic students. More details are available HERE.
· high industrial and scientific relevance (e.g., for powder processing, petroleum engineering, or space science)
· computer(s) with installed, fully documented, and tested DEM simulation software LIGGGHTS®. Tutorials, screencasts, and personal training on the DEM simulator can be provided. Based on the interest of the student(s), an introduction to C/C++ programming can be provided to allow students to extend the simulation software
· desk and office space for writing the bachelor thesis
Stefan Radl, radlnoSpam@tugraz.at; 0680 / 12 22 168. The bachelor thesis projects can be started earliest by April 1st 2017. However, thesis work during the summer months would be preferred.
Swallowing issues of standard tablets and capsules is an increasing issue in delivering especially higher dosed medicines to patients. One of the most promising approaches is the use of small multiparticulate systems that can be dispersed in food or beverages for administration. In order to achieve a precise dose of the medicine, a precise dose of multiparticulates is filled into two piece capsules, which are opened before the administration.
This thesis will focus on the engineering concept development of a capsule opening device by simple manual opening mechanism. This master thesis will include a variety of different research tools from literature research to engineering concept development and preliminary functional assessment. The master student will be supervised by myself and supported by PhD students.
· Understanding in mechanical systems and engineering
· Motivation and creativity towards problem solving
· Interest in working on medical device development and human factored design
· A project that matters the patient and is highly relevant for the pharmaceutical industry
· A thesis in the fast evolving field of patient centric drug products
· Coaching and career development support
· Financial support during the thesis work
Univ.-Prof. Dr. Sven Stegemann
TU Graz - IPPT
Phone: +43 316 873 0422
Detailed understanding of film coating processes is of utmost importance for designing drug products that are sensitive to heat and moisture during production. Conditions such as the local temperature (of tablets or particles), local humidity, as well as the film thickness on the particles are critical quality attributes that determine film formation. Unfortunately, there is a lack of quantitative information on how these critical quality attributes affect the coating process. Since it is tedious to perform experimental studies to answer such questions, simulations can help in collecting data to establish a quantitative and mechanistic understanding of the coating process.
The thesis‘ work will focus on performing a literature research on film coating and drying process, characterization of the „microenvironment“ by means of dimensionless numbers, and computer simulations to quantify the relevance of these dimensionless numbers on the coating process. For the latter, computational tools will be used to simulate the coating and drying of liquid film on the spherical particles. Theoretical developments will complement computational work.
Contact: Ass.-Prof. Dr. Stefan Radl (firstname.lastname@example.org, 0680/12 22 168)
Possible Start Date: February 2015 or later
Master thesis Characterization of microenvironment in a coater
Prediction of the condensation rate of vapors on particles is of fundamental interest for a variety of engineering applications, like nano particle detection, application of coatings to nano particles, or the formation of clouds in the atmosphere. Specifically, the very early stage of the condensation process, typically referred to as nucleation, is of interest, since this stage determines whether condensation does occur or not. Starting with the seminal work of Fletcher (1958), a sound theoretical framework for heterogeneous nucleation on spherical particles has been built in the last decades. Unfortunately, there are significant gaps in our current understanding of the condensation rate on particles with a more complex morphology. The proposed Master Thesis aims on providing a theoretical basis for closing this gap.
The thesis’ work will focus on developing a theoretical understanding of the effect of the contact angle and the morphology of the particle on the initiation of condensation. Specifically, the thesis should include (i) an analysis of relevant literature, (ii) computational studies to investigate the shape of liquid droplets on a variety of morphologically-complex particles, as well as (iii) a theoretical analysis to predict heterogeneous nucleation phenomena on these particles.
This thesis is sponsored by a world-wide leading company in the field of particle analysis, i.e., AVL List GmbH. Appropriate financial and technical support will be provided by AVL List GmbH (€ 2500, plus optional extra payment of € 800); academic supervision will be provided by the Institute of Process and Particle Engineering.
Start Date April 2015