Crystallization is one of the most important unit operations in the production of active pharmaceutical ingredients (APIs) in a solid form. It defines product properties like purity, crystalline structure, crystal size and the crystal size distribution, which is especially important for further downstream operations like filtration and formulation of pharmaceuticals. Because of lower production volumes in the pharmaceutical industry compared to industrial inorganic salt production, the development of continuous processes for the production of certain APIs was not profitable in the pharmaceutical industry in the last decades.
Nevertheless, companies are now investing into the development of continuous processes for synthesis and also crystallization, since a constant quality can be ensured and no service time in between production batches is necessary. Therefore, crystallizers and crystallization processes for continuous applications have to be developed.
The aim of this master thesis is to design and characterize a continuous crystallizer by exploiting recent advances that have been accomplished in the field of additive manufacturing (3D-printing). Based on the working principle of an OSLO-type crystallizer, this technique will facilitate realizing a modular setup. Thereby, rapid replacement of parts of the reactor is feasible, allowing to analyze their influence on the overall behavior. This strategy aims to provide previously unattainable insights into the behavior of continuous crystallizers. The main challenge of the thesis will be the characterization of the current crystallizer using simple model systems. In a possible second step, alternative designs should be evaluated and produced, using additive manufacturing, to optimize the overall performance of the crystallizer.
Figure 1: Current Design of the OSLO type crystallizer.
What we offer:
Dipl.-Ing. Nys Nico, BSc nico.nysnoSpam@tugraz.at - Tel.: +4331687330438
Assoc. Prof. Dipl.-Ing. Dr.techn. Heidrun Gruber-Wölfler woelflernoSpam@tugraz.at
Background Polymers are used in the electrical industry to insulate devices. Especially in corrosive atmospheres the investigation of the degradation of these polymers and the protected devices is of vital importance to increase their longevity. One main influence is the diffusion of corrosive substances through the protective layer of a device. In recent years as computational power became cheaper, using molecular dynamics simulations to quantify transport properties of polymers became more commonly used.
In this thesis molecular dynamics (MD) simulations should be used to quantify the transport processes of different penetrator molecules in polymers. Investigations regarding the polymer’s chain-length, the degree of cross-linking, as well as the charge of the penetrator molecules under different environmental conditions should be conducted.
Work on the thesis is paid (6 months), and we offer office space, computers, simulation software and expertise, as well as integration to a highly-relevant research project
Contact Dr. Stefan Radl (radlnoSpam@tugraz.at; 0680 12 22 168) Dipl.-Ing. Philipp Mayr, BSc. (philipp.mayrnoSpam@tugraz.at)
The Institute of Process and Particle Engineering is a world leader in the development of pharmaceutical products and processes.
In this context, we are offering a paid master thesis where the student is employed at an external company.
The goal of the master thesis is to create the basis for product development, focusing on a novel drug delivery system where the medicine is contained in a flavored gel, either as solution, emulsion or suspension. Drug delivery occurs via breaking a seal of a snap-package and sucking out the flavored gel. Target patient populations includes:
Start: Spring 2021
Contact: Univ.-Prof. Dr. Johannes Khinast, khinastnoSpam@tugraz.at
The Institute of Process and Particle Engineering is a world leader in the development of simulation tools for industrial-scale bioprocessing units, funded by the Spin-Off Fellowship Program of the FFG. For example, our current code can model processes in large-scale bioreactors, up to 200m3 . We are therefore offering a student job with the possibility to do a master thesis with the goal of creating a comparison algorithm for bioreactors. The objective is to find the influencing factors that determine the productivity difference between reactors. This should be done by comparing reactors of different scales and for reactors at the same scale but different geometry and should aid scale up or process transfer processes in the industry.
Start: Fall 2020
Contact Dr. Christian Witz 0316 873 30416 christian.witznoSpam@tugraz.at
For this construction thesis we are looking for a student to design a water bath made of stainless steel for continuous cooling crystallization in a tubular reactor (plug flow crystallizer).
Using such a tubular crystallizer the continuous cooling crystallization process should be carried out in two water baths of different temperature. Each water bath has separate glass inserts which enable the visual observation of the crystallization process within the tubes via a high speed camera. To achieve high resolution images a backlight source e.g. a LED panel in addition to the camera is necessary. Due to the reflection of the water inside the bath the distance between the backlight and the camera should be as short as possible. To keep the tube cycles uniformly immersed and to guide them special tube mountings are also required.
What we offer
Dipl.-Ing. Alexander Meister, BSc Inffeldgasse 13 / III, 8010 Graz alexander.meisternoSpam@tugraz.at
Institut für Prozess- und Partikeltechnik