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Paid Master Thesis or student job: Comparing Bioreactors with different scales and/or geometries

Background

The Institute of Process and Particle Engineering is a world leader in the development of simulation tools for industrial-scale bioprocessing units, funded by the Spin-Off Fellowship Program of the FFG. For example, our current code can model processes in large-scale bioreactors, up to 200m3 .
We are therefore offering a student job with the possibility to do a master thesis with the goal of creating a comparison algorithm for bioreactors. The objective is to find the influencing factors that determine the productivity difference between reactors. This should be done by comparing reactors of different scales and for reactors at the same scale but different geometry and should aid scale up or process transfer processes in the industry.

Tasks

  • Literature study on available influencing factors or comparison concepts for the production in bioreactors using cells or microorganisms
  • Propose an algorithm for the comparison of reactors
  • Do scale ups or process transfer virtually

Requirements

  • Background in biotechnology, biochemistry, molecular microbiology or similar
  • Being familiar with industrial production in bioreactors

What we offer:

  • Integration in an internationally leading team
  • Opportunity to be part of a commercialization project
  • Paid thesis

Start: Fall 2020

Contact
Dr. Christian Witz
0316 873 30416
christian.witznoSpam@tugraz.at


Bachelors’ or Masters’ Thesis - Development of biodegradable protein formulations in solid state

Biopharmaceuticals steadily increase in market share on the pharmaceutical market. New and innovative formulations for biopharmaceuticals such as protein-based drugs are of high interest for the future. Currently biopharmaceutical drugs are either formulated liquid based or freeze-dried.

Our research group focuses on alternatives to freeze drying such es e.g. spray drying (SD, Figure 1 right). The drying of a droplet to a solid particle encompasses three main steps; i) atomization of the feed formulation into micron sized droplets, ii) drying in several drying stages to a solid particle and iii) collection of the produced protein powder. The process parameters (e.g. inlet temperature, volumetric drying air rate, spray rate) and process configuration (e.g. type of nozzle, residence time) strongly interplay with the formulation properties such as viscosity, surface tension or protein concentration (Figure 1). In depth knowledge and sound understanding of the process and formulation correlations with regard to the product should be developed throughout this study.

This work includes literature research on excipient candidates and design of experiments (DoE), followed by setting up a DoE and the classification of excipient properties and performing of drying experiments. We offer you high scientific and industrial relevant work in the emerging field of drying biopharmaceuticals. You will be supported from the IPPE project team and obtain desk and office space. In case of a Masters’ thesis monetary compensation is possible.

Figure 1: Left: protein dispersed in excipient matrix (e.g. polymer); right: schematic representation of a spray dryer. Interplay between formulation properties and process settings on protein and powder characteristics should be evaluated.

Sparked interest?

Contact: Daniela Fiedler,
daniela.fiedlernoSpam@tugraz.at, +43 316 873 30418

Start: as soon as possible


Optimierung der Kristallisation bei der Herstellung von Methacrylamid

Röhm ist ein führender Anbieter der Methacrylat-Chemie weltweit. Als globales Unternehmen 
mit  15  Produktionsstandorten  auf  vier  Kontinenten  sind  wir  nah  an  unseren  Kunden  und 
Märkten.  Unser  Anspruch:  wir  wollen  als  weltweit  führender  Partner  in  Qualität  und 
Zuverlässigkeit gemeinsam mit unseren Kunden die Zukunft der Methacrylat-Märkte gestalten. 
Unser strategisches Zielbild ist klar: Wir werden der führende Methacrylat-Verbund.  
Derzeit wird Methacrylamid in einem langjährig etablierten Verfahren hergestellt. Um weiterhin 
eine hohe Produktqualität gewährleisten zu können optimieren wir ständig unsere Prozesse. 
Aktuell arbeiten wir an der Problematik die Trübung (Methacrylamid gelöst in organischem 
Lösungsmittel) in unserem Endprodukt zu reduzieren.  
Aus diesem Grund suchen wir in Worms, dem größten Standort von Röhm weltweit, eine/n 
motivierte/n  Studierende/n  als  Unterstützung  im  Produktionsbetrieb  für  Methylmethacrylate 
und Methacrylamid.

Themenschwerpunkte hierbei sind: 

  • Literaturrecherche und Vergleich zu Alternativverfahren
  • Untersuchungen  zur  Bildung  von  interkristalliner  Trübung  (Löseversuche  nach Lagerungszeit und Korngröße)
  • Optimierung der Korngrößenverteilung in Hinsicht auf: Trübung, Rieselfähigkeit und Explosionsfähigkeit
  • Lager- und Trocknungsversuche in Hinblick auf Verklumpen des Produktes
  • Alternative  Verfahrenskonzepte  sollen  mit  Hinblick  auf  Nebenprodukte  im  Produkt analysiert und bewertet werden
  • Nach der Kristallisation muss im Down-Streaming getrocknet werden, daraufhin soll die Feuchte und Verweilzeit des Schüttguts im Fließbetttrockner und im Tellertrockner untersucht und idealerweise die Prozessparameter optimiert werden
  • In Praxisversuchen / Optimierung an der laufenden Anlage soll der Einfluss der Verweilzeit, Temperatur und Konzentration auf die Korngrößenverteilung im Kristallisator untersucht und dokumentiert werden

Richtet sich an Studierende mit folgenden Voraussetzungen

  • Mechanische Verfahrenstechnik I (wünschenswert auch II)
  • Thermische Verfahrenstechnik I (wünschenswert auch II)
  • Grundlagen Analytische Chemie
  • Thermodynamik
  • Idealerweise Labor/Praxis Erfahrung

Kontakt

Assoc. Prof. Dipl.-Ing. Dr.techn. Stefan Radl 
radl(at)tugraz.at

Assoc. Prof. Dipl.-Ing. Dr.techn. Heidrun Gruber-Wölfler 
woelfler(at)tugraz.at

Dr. Markus Maier
markus.maier(at)roehm.com 
www.roehm.com

Röhm GmbH
Im Pfaffenwinkel 6
67547 Worms
Germany


Development of UV-based Reactor to Inactive Virus-particles in Inside Air (Paid Master Thesis)

Background

The current COVID-19 crisis highlights the need to treat inside air, as inside-air viral transmission  is  considered  an  important  route  of  infection.  Interestingly,  UV-based irradiation of virus particles is known to inactivate the virus.  Thus, the goal of the thesis is to develop a low-cost UV-based air flow-through device (UV decontamination reactor) that can be integrated in typical air handling systems in restaurants, movie theatres, concert halls, trains, etc.

Tasks

  • Literature study on available UV-based de-contamination systems  
  • Understanding the requirement of a system in terms of integration in air-handling systems   
  • Basic design of the reactor chamber with respect to UV-exposure and residence time distribution using a simple (e.g., analytical or semi-analytical) model   
  • Air flow optimization via flow simulation (CFD)   
  • Building a prototype of the UV-based reactor   
  • Interaction with Universities that can study the impact of UV on viral inactivation

Requirements

  • Background in chemical engineering, mechanical engineering   
  • Basic computer knowledge   
  • CFD knowledge is an advantage   
  • Interest in developing a novel system

What we offer:

  • Integration in an internationally leading institute (IPPT) of TU Graz
  • Opportunity to be part of a commercialization project
  • Paid thesis

Start: Summer/Fall 2020

Contact

Assoc. Prof. Dr. Stefan Radl
Univ.-Prof. Dr. Johannes Khinast
(radlnoSpam@tugraz.at, khinastnoSpam@tugraz.at)


Continuous Cooling Crystallization

Background

For this construction thesis we are looking for a student to design a water bath made of stainless steel for continuous cooling crystallization in a tubular reactor (plug flow crystallizer).

Using such a tubular crystallizer the continuous cooling crystallization process should be carried out in two water baths of different temperature. Each water bath has separate glass inserts which enable the visual observation of the crystallization process within the tubes via a high speed camera. To achieve high resolution images a backlight source e.g. a LED panel in addition to the camera is necessary. Due to the reflection of the water inside the bath the distance between the backlight and the camera should be as short as possible. To keep the tube cycles uniformly immersed and to guide them special tube mountings are also required.

Tasks

  • To design a water bath of stainless steel with glass inserts for the image-based observation of a continuous cooling crystallization within a transparent tubular crystallizer.
  • To make a selection of necessary materials and equipment and process the orders
  • Image-based monitoring and observation of crystal segments via high speed camera and backlight
  • Doing some final experiments to demonstrate the applicability of the two water baths for visual investigations.


Requirements

  • Background in chemical / pharmaceutical engineering or chemistry
  • Basic experience in working with CAD drawing desirable
  • Basic experience in lab work

What we offer

  • Integration in an internationally leading team

Contact

Dipl.-Ing. Alexander Meister, BSc
Inffeldgasse 13 / III, 8010 Graz
alexander.meisternoSpam@tugraz.at



Paid Master’s Thesis - Development of a Dosing Unit for the Production of personalized Tablets

The fact that human beings differ from each other, regarding their physiology, pathology and environment suggests, that not everyone can be treated using the same medication. Therefore, a trend towards personalized medicine is observable. This trend brings up some challenges, as it comes to the production of tablets. The dose of the Active Pharmaceutical Ingredient (API) as well as the amount of any excipient needs to be dosed accurately, for each individual tablet.

The development of a device being capable to do so, is the goal of this thesis. As the dosing shall be done gravimetrically, the dosing unit will contain a feeder and a weighing cell. A scheme of the set-up and its features can be seen below.


Your work will include the following points:
•    Picking a development environment (LabView, Arduino/Raspberry Pi, …)
•    Picking a weighing cell with sufficient accuracy and fitting dynamic properties
•    Integration of weighing cell and feeder in an environment for control and data acquisition
•    Investigation of the feeding/dosing characteristics of the set-up
•    Development of a self-adjusting dose algorithm

We offer
•    High scientific and industrial relevance (the approach involving this dosing process could speed up the development in pharmaceutical industry and allow to produce personalized medicine)
•    Support from the IPPE project team and Prof. Horn from IRT
•    Desk and office space

Contact:
Andreas Kottlan, andreas.kottlannoSpam@tugraz.at, 0316-873-30419
Starting date: as soon as possible 2020


Paid Master’s Thesis - Investigations on a Sonic Mixing Process

Sonic mixing is a relatively new approach for mixing various systems. The process is used to some extend in pharmaceutical industry to produce powder mixtures and pastes. To achieve a satisfying mixing quality, the system is exposed to vibration with high acceleration and high amplitudes in means of travel. This is commercially realized by using a system working at resonance frequency to minimize the power input.

We aim for a much smaller system size, i.e. the mass of single tablet. This allows us to get rid of the need for a system operated at resonance. Therefore, the frequency can be varied to achieve the most effective mixing process. A schematic sketch of the setup can be seen in figure 1.

This thesis shall bring insight to some specific points:
•    How do the operating parameters, i.e. frequency and amplitude affect the flow pattern within the mixing vessel?
•    How does the “flow regime” within the mixing chamber affect the mixing performance?
•    How do different powders react to different operating parameters?
•    Is it possible to find a robust mode of operation which provides satisfying results for various powder systems?
•    Can coating or granulation processes be done using this setup?

The investigation on these topics shall be done using an existing experimental setup, which can be modified to meet arising requirements. The student shall elaborate a design of experiments which covers the relevant operating range of the used vibration generator and accounts for different powder blends. Once defined, the mixing experiments are to be carried out. The blends, produced in this way, need to be analysed. The search for meaningful analysis methods is part of this work.

We offer
•    High scientific and industrial relevance (the approach involving this mixing process could speed up the development in pharmaceutical industry and allow to produce personalized medicine)
•    Support from the IPPE project team
•    Desk and office space

Contact:
Andreas Kottlan, andreas.kottlannoSpam@tugraz.at, 0316-873-30419
Starting date: as soon as possible


PAID MASTER’S THESIS: Influence of powder composition on macroscopic powder properties

To dedicated students who are interested in the pharmaceutical field (i.e. students of chemical engineering, pharmaceutical engineering, biomedical engineering, pharmacy, or related disciplines), we offer an opportunity to write a paid Master’s thesis.

OBJECTIVE:
Powder processing steps, such as feeding and mixing, are critical in many industries, including the pharmaceutical industry. For example, within a continuous tablet manufacturing environment, powder feeding impacts functionality and quality of the final product. For the rational design of such operations the powder properties need to be known, including the particle size distribution, bulk (poured) and tapped density, flowability, compressibility, electrostatic chargeability and tendency to segregate.

Thus, the development of solid dosage forms and the associated manufacturing processes requires a good understanding of the relationship between powder composition and the properties of the powder.

WITHIN THE FRAMEWORK OF THIS MASTER’S THESIS WE OFFER THE FOLLOWING:

  • Extensive participation in a top-level and industrially relevant research project in an international environment Supervised training in the task
  • Assistance of experienced staff with the implementation of innovative ideas
  • Access to highly modern infrastructure on campus of Graz University of Technology
  • Assistance with the publication of results Adequate compensation and opportunities for personal and professional development

FINANCING:
Compensation on the basis of a service contract

If you are interested in writing your thesis at the process and particle engineering institute of TUGraz, please contact us indicating the reference number. Candidates will be selected on a competitive basis and will be selected without regard to sex, race or nationality.

Contact: Sara Fathollahi (sara.fathollahinoSpam@tugraz.at, 0316 873 30938)


Exploiting Artificial Intelligence in Gas-Particle Flow Simulations

Current trends in advanced multiphase flow prediction aim at the usage of machine learning algorithms and deep neural networks to improve the accuracy and to speed-up numerical simulations. Overall, it can be expected that these tools (and artificial intelligence, AI, in a wider context) will become an important part of numerical modelling used in chemical engineering applications.

The overarching goal of this Master Thesis project is to increase the speed of gas-particle flow simulations (see the right panel in the Figure below) by using an AI-powered prediction algorithm.

Your tasks will include (i) a literature review on the usage of deep learning in numerical simulations, (ii) an investigation related to key parameters of a neural net structure to speed up a widely-used gas-particle flow simulator, and (iii) application of the improved simulator to a use case. The machine learning and deep neural nets will be based on existing open source AI platforms (e.g., Tensorflow), for which expert knowledge is already available at our institute.

Qualification

  • Interest in Computational Fluid Dynamics (CFD), Discrete Element Method (DEM)
  • Basics programming skills (Matlab/octave, Python, C/C++ or other), and interest to refine your programming skills during the Master Thesis project

We offer

  • Extremely high scientific and industrial relevance
  • Introduction to the leading open-source gas-particle simulation tools OpenFOAM® and CFDEM®. Support with the AI platform, as well as with respect to programming.
  • Computer power, desk and office space
  • Possibility to publish the results and findings in a scientific journal

Contact

Josef Tausendschön: josef.tausendschoennoSpam@tugraz.at, Stefan Radl: radlnoSpam@tugraz.at

Kontakt
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Michaela Cibulka
Mag.phil.

Institut für Prozess- und Partikeltechnik
Inffeldgasse 13
8010 Graz

Tel.
+43 (316) 873 - 30403
Fax
+43 (316) 873 - 1030403
Sprechstunden
nach Vereinbarung