15.07.2020

New paper on SAR studies of ATGL inhibitors


In our latest publication in Bioorganic & Medicinal Chemistry, we disclose structure–activity relationship (SAR) studies of small molecule inhibitors of murine adipose triglyceride lipase (mATGL) that resulted in the development of Atglistatin as powerful tool compound.
https://www.sciencedirect.com/science/article/pii/S0968089620304405

 

14.07.2020

Congratulations to Corina Maller


Corina just finished her Master studies! We wish you all the best for your upcoming PhD studies in Freiburg!

04.05.2020

New paper on stereoselective synthesis of thiol-containing 1,2-aminoalcohols

In this contribution published in Tetrahedron, we report a synthetic protocol for the stereoselective preparation of highly functionalized aminohydroxythiols. The methodology is based on a SmI2/LiBr-mediated reductive coupling of Ellman N-sulfinylimines with aldehydes.
https://www.sciencedirect.com/science/article/pii/S0040402020303926

30.04.2020

Congratulations to Niklas Pontesegger


Niklas Pontesegger just finished his Master studies doing a marvelous job at his exam! We wish you all the best for your upcoming PhD studies!

23.04.2020

Congratulations to Martin Vařeka


Today Martin Vařeka defended his PhD thesis on quateraryl alpha-helix mimetics as inhibitors for protein-protein interactions (PPIs) in the first-ever online defense at our Institute. We congratulate on this achievement and are looking forward to his party at a later date!

19.03.2020

New publication on alpha-helix mimetics

In this study a highly modular synthesis of quateraryl alpha-helix mimetics as inhibitors for protein-protein interactions (PPIs) is presented. The combination of an electroorganic as well as a Pd-catalyzed cross-coupling provides efficient access to quaterarylic systems. This work was published in Catalysts.
https://www.mdpi.com/2073-4344/10/3/340

06.03.2020

Congratulations to Anna Migglautsch

Anna Migglautsch just defended her PhD thesis on “Development of inhibitors of human adipose triglyceride lipase (hATGL)”. We want to thank her for the last years in which she became an essential member of the Institute and congratulate on doing an amazing job at her defense!

01.02.2020

New Senior Scientist: Rita Fürst

Today Rita Fürst has started her new position as Senior Scientist at our Institute!

06.01.2020

Press release on drug development

The Austrian Research Promotion Agency (FFG) just published a press release on the development of a drug candidate for diabetes treatment. This joint research project between the Institute of Molecular Biosciences (University of Graz) and the Institute of Organic Chemistry (TU Graz) focuses on the synthesis of small molecule inhibitors of the adipolytic enzyme ATGL.
https://www.ffg.at/sites/default/files/allgemeine_downloads/strukturprogramme/RSA/RSA_Studios_A3_Atglistatin.pdf

11.12.2019

Institute tour

Today a group of students from the BORG Birkfeld visited our Institute in the course of their NAWI Graz day at TU Graz. We hope that you enjoyed your tour through our lab facilities!

01.12.2019

New PhD-Student: Till Schreiner

Today Till Schreiner started as new PhD-Student and University Assistant at the Institute!

11.11.2019

 Congratulations to Till Schreiner

Till Schreiner just finished his Master studies! We are looking forward to welcome him as PhD student soon.

07.11.2019

New study on highly selective Pd-catalyzed S-allylation

In our latest publication we disclose a palladium-catalyzed protocol for the highly chemo- as well as regioselective S-allylation of thiols. This transformation developed at the Institute of Organic Chemistry offers several advantages over established reaction for the synthesis of thioethers. The paper was published in Advanced Synthesis & Catalysis and highlighted as “very important publication”!
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201901250

15.10.2019

New PhD-Student: Michael Frieß

We would like to welcome Michael Frieß as new PhD-Student at the Institute!

11.10.2019

Press release on new method for the synthesis of lipidated proteins

TU Graz just published a press release on the development of a new method for the site-selective lipidation of proteins. This palladium-mediated reaction was developed at the Institute of Organic Chemistry (TU Graz) in collaboration with the Institute of Biological Chemistry (University of Vienna) and recently published in the Journal of American Chemical Society.
https://www.tugraz.at/en/tu-graz/services/news-stories/media-service/singleview/article/neues-verfahren-zur-schnelleren-und-einfacheren-herstellung-lipidierter-proteine0/

10.10.2019

Farewell party for Prof. Norbert Klempier

After a great farewell party at Buschenschank Schneiderannerl, we wish Prof. Norbert Klempier all the best for his retirement!

18.09.2019

New MSc-Student: Corina Maller


We would like to welcome Corina Maller for her Master Thesis at the Institute!

02.09.2019

New MSc-Student: Niklas Pontesegger

We would like to welcome Niklas Pontesegger for his Master Thesis at the Institute!

02.09.2019

New Senior Post-Doc: Melanie Trobe

Today Melanie Trobe (PhD alumnus) arrived back from her two-year post-doctoral stay in the lab of Martin D. Burke at the University of Illinois in the U.S. As a recipient of the Erwin Schrödinger Fellowship, she will now join the group of Prof. Breinbauer for her return phase.