2016
Norbert Klempier Kinetic analysis and probing with substrate analogues of the reaction pathway of the nitrile reductase QueF from Escherichia coli The Journal of Biological Chemistry 2016, 25411-25426, 2016
2015
Norbert Klempier A convenient synthetic route to substituted pyrrolo[2,3-b]pyridines via a novel ethylene-bridged compound Tetrahedron letters 2015, 6606-6609, 2015
Norbert Klempier An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain Organic & biomolecular chemistry 2015, 7803-7812, 2015
Norbert Klempier A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines Tetrahedron letters 2015, 4486-4489, 2015
2014
Norbert Klempier Enzymatic Reductions of unconventioal substrates: Carboxylates and Nitriles
Norbert Klempier In Vitro Reconstruction of Queuosine biosynthesis in Geobacillus kaustophilus: two step cascade from 7-carboxy-7-deazaguanin to PreQ1
Norbert Klempier ACIB Jahresbericht 2014 Enzymatic Nitrile Reduction
Norbert Klempier Unconventional Enzymatic Reductions: Nitriles and Carboxylates as Substrates
Norbert Klempier Unconventional Enzymatic Reductions: Nitriles and Carboxylates as SubstratesUnconventional Enzymatic Reductions: Nitriles and Carboxylates as SubstratesS1-S2
2013
Norbert Klempier Biocatalytic synthesis of taxol sidechain precursors
Norbert Klempier Exploring the active binding site of nitrile reductase queF
Norbert Klempier Biological nitrile reduction – exploring a remarkable reaction
Norbert Klempier Syntheses of substituted thieno-, cyclopenta- and pyrazolopyrimidines
Norbert Klempier ACIB Jahresbericht 2013 Enzymatic Nitrile Reduction
Norbert Klempier Exploring the Active Binding Site of Nitrile Reductases
Norbert Klempier Synthesis of a taxol sidechain precursor with bacterial and fungal nitrilases
Norbert Klempier Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering Chemistry - A European Journal 2013, 7007-7012, 2013
Norbert Klempier Enzymatic Nitrile Reduction
Norbert Klempier ACIB International Scientific Advisory Board - Project Report Enzymatic Nitrile Reduction
2012
Norbert Klempier ACIB International Scientific Advisory Board - Project Report Enzymatic Nitrile Reduction
Norbert Klempier Enzymatic Nitrile Reduction
Norbert Klempier Enzymatic Nitrile Reduction
Norbert Klempier A Two Enzyme Approach to a Taxol Sidechain Precursor
Norbert Klempier ACIB Jahresbericht 2012 Enzymatic Nitrile Reduction
Norbert Klempier Synthesis of 7-deazaguanine analogues including a novel biotransformation step
Norbert Klempier Biocatalytic nitrile reduction with wild type and mutant nitrile reductases
Norbert Klempier Investigations of the substrate scope of nitrile reductase queF
Norbert Klempier NITRILE REDUCTASE FROM GEOBACILLUS KAUSTOPHILUS: A POTENTIAL CATALYST FOR A NEW NITRILE BIOTRANSFORMATION REACTION Advanced Synthesis & Catalysis 2012, 2191-2198, 2012
2011
Norbert Klempier Nitrile Reduction using Nitrile Reductase
Norbert Klempier PREPARATION OF AN ENANTIOENRICHED TAXOL SIDECHAIN PRECURSOR BY NITRILASE AND NITRILE HYDRATASE
Norbert Klempier Enzymatic Nitrile Reduction
Norbert Klempier Biocatalytic synthesis of an enantioenriched taxol sidechain precursor
Norbert Klempier Enzymatic Nitrile Reduction
Norbert Klempier Enzymatic Nitrile Reduction using wild type and mutant Nitrile Reductase QueF
Norbert Klempier Preparation of an enantioenriched taxol side chain precursor by nitrilase and nitrile hydratasePreparation of an enantioenriched taxol side chain precursor by nitrilase and nitrile hydratase76-76
Norbert Klempier Enzymatic Nitrile reduction
Norbert Klempier Enzymatic Nitrile Reduction using wild type and mutant Nitrile Reductase QueFEnzymatic Nitrile Reduction using wild type and mutant Nitrile Reductase QueF76-76
2010
Norbert Klempier Biotransformation of Purine and Pyrimidine CarbonitrilesBiotransformation of Purine and Pyrimidine Carbonitriles150-150
Norbert Klempier Engineered Alcaligenes faecalis nitrilases
Norbert Klempier Biotransformation of Purine, Pyrimidine and Pyrrole Carbonitriles
Norbert Klempier ACIB Jahresbericht 2010
Norbert Klempier Biotransformation of Purine and Pyrimidine Carbonitriles
Norbert Klempier Directed evolution of Alcaligenes faecalis nitrilase Enzyme and microbial technology 2010, 140-146, 2010
2009
Norbert Klempier BIOCATALYTIC APPLICATION OF NITRILASES FROM FUSARIUM SOLANI O1 AND ASPERGILLUS NIGER K10 Journal of molecular catalysis / B 2009, 243-247, 2009
Norbert Klempier Nitrile transforming enzymes in enantioselective synthesis of non-proteinogenic amino acids
Norbert Klempier ENANTIOSEPARATION OF NONPROTEINOGENIC AMINO ACIDS Analytical and Bioanalytical Chemistry 2009, 1789-1796, 2009
Norbert Klempier Enantioseparation of Non-proteinogenic Amino Acids Analytical and Bioanalytical Chemistry 2009, 1789-1796, 2009
Norbert Klempier Nitrilase and Nitrile Hydratase Catalyzed Enantioselective Preparation of Non-proteinogenic Amino AcidsNitrilase and Nitrile Hydratase Catalyzed Enantioselective Preparation of Non-proteinogenic Amino Acids247-260
2008
Hansjörg Weber and Norbert Klempier Influence of relative configuration of disubstituted cyclopentanes and –hexanes on 13C shifts Magnetic resonance in chemistry 2008, 865-871, 2008
2007
Norbert Klempier Nitrilase catalyzes key step to gamma-amino acids in high optical purity
Norbert Klempier Nitrilases catalyze Key Step to conformationally constrained GABA analogous gamma-Amino Acids in high Optical Purity The journal of organic chemistry 2007, 7423-7426, 2007
Norbert Klempier Asymmetric Synthesis of Cyclic Amino Acids
Hansjörg Weber and Norbert Klempier Nitrilase catalyzed enantioselective Synthesis of Pyrrolidine and Piperidine Carboxylic Acids
Norbert Klempier Nitrilase catalyzed enantioselective Synthesis of Pyrrolidine and Piperidine Carboxylic Acids Advanced Synthesis & Catalysis 2007, 1475-1480, 2007
2006
Norbert Klempier Nitrilase catalyzed Synthesis of GABA Transition State Analogues
Norbert Klempier Enzyme stabilizer DTT catalyzes nitrilase analogue hydrolysis of nitriles Chemical Communications 2006, 1298-1300, 2006
Norbert Klempier Biotransformations employing Nitrile converting Enzymes
Norbert Klempier Nitrilase catalyzed Synthesis of GABA Transition State Analogues
Norbert Klempier SYNTHESIS OF DIASTEREOISOMERIC ß- AND y-FLUORO NITRILES
2005
Norbert Klempier Synthese regio- und stereoisomerer ß-Aminoindannitrile
Norbert Klempier Microbial preparation of Cispentacin-derivatives
Norbert Klempier Enzyme Mediated Three Step Preparation of the TAXOL-side Chain Starting from Benzaldehyde.
Norbert Klempier Enzyme mediated three step Preparation of the Taxol SideChain starting from Benzaldehyde
Norbert Klempier Enantioselective preparation of ß-amino acids and amides using nitrile hydrolyzing enzymes
Norbert Klempier Microbial preparation of Cispentacin-derivativesMicrobial preparation of Cispentacin-derivatives188-188
Norbert Klempier Enantioselective microbial transformation of ß-amino nitrilesEnantioselective microbial transformation of ß-amino nitriles1-349
Norbert Klempier Enantioselective microbial transformation of ß-amino nitriles
2004
Herfried Griengl and Norbert Klempier Microbial Hydrolysis of ß-Aminonitriles
Norbert Klempier Trends of nitrile hydratase/amidase catalyzed transformation of alicyclic ß-amino nitrilesTrends of nitrile hydratase/amidase catalyzed transformation of alicyclic ß-amino nitriles1-278
Norbert Klempier Synthese regio- und stereoisomerer ß-Indannitrile
Norbert Klempier Trends of nitrile hydratase / amidase catalyzed transformation of alicyclic -amino nitriles
Norbert Klempier Trends of nitrile hydratase/amidase catalyzed transformation of alicyclic ß-amino nitriles
Helmut Hönig and Norbert Klempier Biotransformation of beta-amino nitriles: the role of the N-protecting group Journal of molecular catalysis / B 2004, 115-121, 2004
2003
Norbert Klempier Biocatalytic Characterization of Esterases Journal of Biotechnology 2003, 2003
Norbert Klempier Biotransformation of N-protected ß-Amino Nitriles to ß-Amino Acids.
Norbert Klempier A NEW APPROACH TO ß-AMINO ACIDS: BIOTRANSFORMATION OF N-PROTECTED ß-AMINO NITRILES Tetrahedron letters 2003, 5057-5059, 2003
Norbert Klempier Biotransformation of N-protected b-Amino Nitriles to b-Amino AcidsBiotransformation of N-protected b-Amino Nitriles to b-Amino Acids325-526
2002
Norbert Klempier SELECTIVE BIOTRANSFORMATION OF SUBSTITUTED ALICYCLIC NITRILES BY RHODOCOCCUS EQUI A4 Canadian Journal of Chemistry 2002, 724-727, 2002
2001
Norbert Klempier ASYMMETRIC TRANSFORMATIONS BY COUPLED ENZYME AND METAL BIOCATALYTIC POTENTIAL OF A NITRILE-CONVERTING MICROORGANISM, RHODOCOCCUS EQUI STRAIN A4ASYMMETRIC TRANSFORMATIONS BY COUPLED ENZYME AND METAL BIOCATALYTIC POTENTIAL OF A NITRILE-CONVERTING MICROORGANISM, RHODOCOCCUS EQUI STRAIN A41-492
Herfried Griengl and Norbert Klempier Biotransformation of 3-substituted methyl (R,S)-4-cyanobutanoates with nitrile-and amide-converting biocatalysts. Journal of molecular catalysis / B 2001, 95-99, 2001
Norbert Klempier Biocatalytic potential of a nitrile converting microorganism Rhodococcus equi strain A4
2000
Norbert Klempier Biocatalytic characteristics of bacterial esterases
1999
Norbert Klempier Biocatalytic characteristics of bacterial
Herfried Griengl and Norbert Klempier Proton-NMR-Analyses of the Substrate Specificity of a ß-Ketolase from Pseudomonas putida, Acetopyruvate Hydrolase Biotechnology Letters 1999, 909-912, 1999
Norbert Klempier Chemoselective Biotransformation of Nitriles by Rhodococcus equi A4. Biotechnology Letters 1999, 909-912, 1999
Norbert Klempier Nitrile hydratase and amidase from Rhodococcus rhodochrous Hydrolysis of acrylic fibres and granulates
Norbert Klempier Biotransformations of 2-hydroxynitriles and 3-hydroxynitriles by Rhodococcus equi strain A4
1998
Herfried Griengl and Norbert Klempier Enzyme Catalysed Formation of (S)-Cyanohydrins Derived from Aldehydes and Ketones in a Biphasic Solvent System Tetrahedron 1998, 14477-14486, 1998
1997
Norbert Klempier New Pseudomonas esterases by genetic engineering Journal of molecular catalysis / B 1997, 25-27, 1997
Norbert Klempier Chemoselective Biotransformations of nitriles by Rhodococcus equi strain A4
1996
Norbert Klempier Chemoselective Hydrolysis of Nitriles by Rhodococcus rhodochrous NCIMB 11216 Food technology and biotechnology 1996, 67-70, 1996
Norbert Klempier and Kurt Faber Recombinant Esterases for Organic Synthesis Mededelingen / Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen, Universiteit Gent 1996, 1391-1394, 1996
1995
Norbert Klempier New esterases for organic synthesis by genetic engeneering
Norbert Klempier Synthesis of alpha,-beta-unsaturated (S)-Cyanohydrins using the Hydroxynitrile Lyase from Hevea brasiliensis Tetrahedron / Asymmetry 1995, 845-848, 1995
Norbert Klempier Hevea brasiliensis hydroxynitrile lyase: substrates and selectivities
Norbert Klempier Recombinant esterases for organic synthesis
Norbert Klempier Recombinant esterases for organic synthesis
1994
Norbert Klempier New esterases for organic synthesis by genetic engeneering
Norbert Klempier Molecular cloning and overexpression of an esterase gene from Pseudomonas marginata
Norbert Klempier Lyase catalyzed preparation of enantiomerically enriched cyanohydrins of aliphatic ketones
1993
Herfried Griengl and Norbert Klempier Aliphatic (S)-cyanohydrins by enzyme catalyzed synthesis Tetrahedron letters 1993, 4769-4772, 1993
Norbert Klempier Aliphatic (S)-cyanohydrins by a hydroxynitrile lyase from Hevea brasiliensis
Norbert Klempier Enzyme catalyzed synthesis of bifunctional aliphatic (S)-cyanohydrins
Norbert Klempier Asymmetric Hydrolysis of Epoxides using an immobilised Enzyme Preparation from Rhodococcus sp. Tetrahedron 1993, 1161-1164, 1993
Herfried Griengl, Anna De Raadt, Arnold Stütz and Norbert Klempier A mild and simple enzymatic conversion of aldono and aldurononitriles into the corresponding amides and/or carboxylic acids The journal of organic chemistry 1993, 3179-3184, 1993
Norbert Klempier Purification of a hydroxynitrile lyase from Hevea brasiliensis