The 1st FoE Day of Human & Biotechnology brings together the researchers from these two main disciplines. Talks will be given by scientists who either received a research project after successful FoE seed funding, or made a major step in their careers. Two keynote speakers from external research labs will conclude this event.
14:10 Selina Wriessnegger: Towards BCI technology for healthy users
14:25 Christian Baumgartner: Cardiac engineering: from basic research to clinical application
14:40 Reinhold Scherer: Motor learning and default networks after stroke
14:55 Hermann Scharfetter: CONQUER: New molecular MR imaging from good old physics
15:10 coffee break & poster
15:35 Tanja Wrodnigg: Glycomimetics: Useful Tools and Potential Therapeutics
15:50 Barbara Siegmund: Flavour as an essential quality aspect of foods
16:05 Andreas Winkler: Allosteric signaling in light-regulated enzymatic functionalities
16:20 Regina Kratzer:Multiphasic reaction mixtures - product isolation and beyond
16:35 coffee break & poster
17:00 Keynote: Tomislav Milekovic: Neuroprosthetic technologies to improve motor recovery after spinal cord injury.
18:00 Keynote: Bruno Bühler: Integrated bioprocess development for whole-cell biocatalysis
19:00 get together "roof top mia&mason" , Stremayrgasse 16
Dr. Tomislav Milekovic: Neuroprosthetic technologies to improve motor recovery after spinal cord injury
Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology Lausanne (EPFL)
Severe spinal cord injury leads to a range of disabilities, including permanent motor impairments that seriously diminish the patients’ quality of life. Over the past decade, Courtine lab developed a multipronged intervention that restored supraspinal control over leg movements after severe spinal cord injury in rats. The intervention acts over two time windows. Immediately, electrochemical neuromodulation of spinal circuits enables motor control of the paralyzed legs. In the long term, will-powered training regimens enabled by electrochemical neuromodulation and robotic assistance promote neuroplasticity of residual connections—an extensive rewiring that reestablishes voluntary control of movement. We found that electrochemical neuromodulation therapies enable motor control through the recruitment of muscle spindle feedback circuits. This framework steered the design of spatially selective spinal implants that specifically target these circuits to modulate muscle synergies underlying the flexion or extension of the leg. To modulate these muscle synergies, we interfaced leg motor cortex activity with electrochemical neuromodulation therapies. This brain spinal interface instantly restored robust locomotor movements of a paralyzed leg in non-human primate models. Preliminary clinical studies suggest that our concepts and technologies are directly translatable to therapeutic strategies to augment motor recovery after spinal cord injury in humans.
PD Dr. Bruno Bühler: Integrated bioprocess development for whole-cell biocatalysis
Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
Martin-Luther-University Halle-Wittenberg, Halle, Germany
What are the opportunities of biocatalysis in a future bioeconomy? Production of fuels? Chemicals? Pharmaceuticals? All of them? From what resources and with what technologies? Interesting questions not to be answered simply and maybe not in a comprehensive way, yet. Efficiency regarding the use of resources and productivity are key for the implementation of bioprocesses and largely rely on an integrated approach for bioprocess development. Whole-cell biocatalysis can be considered a promising tool for a future bioeconomy. The living microbial cell is highly attractive as catalyst unit for energy demanding reactions, since it allows efficient cofactor regeneration, self-renewal, and handling of reactive oxygen species. Thus, whole-cell systems pose big chances as well as challenges in terms of catalyst optimization and process control. Beside technical aspects, a large number of concurrent and highly cross-linked biological processes such as recombinant gene expression, energy metabolism, and toxification have to be considered. With the aim to construct the ideal microbial cell for recombinant oxygenase and multistep catalysis, we follow a systems biotechnology approach considering both biological and technical implications on a systems level. Challenges and benefits originating from cellular functionalities will be discussed in the frame of integrated bioprocess development. In this context, the intracellular coupling of multiple enzymes from diverse origin, i.e., orthogonal pathway engineering, will be presented as a tool to produce high volume products, e.g., polymers, from renewables. Furthermore, prospects for the use of phototrophic microorganisms will be given with the goal to make use of sunlight to drive sustainable production.
November 3rd, 2016
2 p.m. to 7p.m.
Lecture Hall Petersgasse 12
7 p.m. get together "mia & mason"
Registration is closed!
If you plan to present a poster indicate it in the Doodle Poll. Poster Format A0 Portrait.