ICBT/Research/Sensen Team

Sensen Team


Research Goals

Christoph W. Sensen is mainly interested in research topics related to Genome Research and Bioinformatics. Having worked previously in Canada, his group has participated in many large-scale Genome Projects, including recently an Oil Sands Metagenomics Research Program and the PhytoMetaSyn Program, which is related to the study of the Expressed Genes in 75 higher plants.

The Computational Biotechnology group began work in Graz in September 2014. By the end of 2015, all of the Computer Equipment will have been relocated from Calgary, Canada to Graz. The hardware and software environment currently being configured will be one of the most powerful Bioinformatics facilities in Austria.

The Computational Biotechnology Group is conducting research, especially related to the identification of serum-based DNA markers for chronic diseases and the development of rapid and cost-effective screening systems for the presence of particular DNA Sequences in the environment, and is also providing services related to high-throughput Bioinformatics analyses.


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Current Projects

  • DNA-based markers identified from Circulating Nucleic Acids (CNA)

    When animals get infected with diseases like Bovine Spongiform Encephalopathy or Bovine Respiratory disease, they start to release exosomes which contain specific DNA molecules into the blood stream. This specific process already starts at early stages of the disease, which makes it a promising candidate for the detection of the disease before any clinical sign could be observed.

    Currently, the diagnostics and monitoring of chronic and infectious diseases in animals and humans is mainly based on the identification of an infective agent. This approach is slowly changing towards the measurement of the reaction of the host to the disease challenge. A new approach is the identification of DNA markers in the serum of diseased production animals (as well as humans), which can be used for the early identification of disease states, ideally before clinical signs emerge.

    This research project is focused on industrial biotechnology enabling (a) the diagnostic of diseases in mammalian systems and (b) developing DNA screening devices for the rapid monitoring of the presence of specific DNA sequences in liquids, especially blood serum, to be used in animal production processes.


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Current Theses

Maximilian Malek
PhD Thesis
Working title: Generating intermediate MRI datasets with applications in vehicle safety


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Partners

Industrial collaborations


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Selected Publications

2019
mzTab-M: a data standard for sharing quantitative results in mass spectrometry metabolomics Show publication in PURE
Christoph Wilhelm Sensen Enterobacteriaceae dominate the core microbiome and contribute to the resistome of arugula (Eruca sativa Mill.) Show publication in PURE
jmzTab-M: A Reference Parser, Writer and Validator for the Proteomics Standards Initiative mzTab 2.0 Metabolomics Standard Show publication in PURE
Gerhard Thallinger A Comprehensive FXR Signaling Atlas Derived from Pooled ChIP-seq Data Show publication in PURE
Petra Heidinger Hydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necator Show publication in PURE
Gerhard Thallinger The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro Show publication in PURE
Christoph Wilhelm Sensen Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus Show publication in PURE
Gerhard Thallinger Utility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patients Show publication in PURE
Gerhard Thallinger Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies Show publication in PURE
Gerhard Thallinger Comparison and evaluation of integrative methods for the analysis of multilevel omics data Show publication in PURE
2018
Gerhard Thallinger Dimension Reduction for the Integrative Analysis of Multilevel Omics DataDimension Reduction for the Integrative Analysis of Multilevel Omics Data Show publication in PURE
Gerhard Thallinger Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells Show publication in PURE
Gerhard Thallinger Methanol independent induction in Pichia pastoris by simple derepressed overexpression of single transcription factors Show publication in PURE
Gerhard Thallinger A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods Show publication in PURE
Christoph Wilhelm Sensen Instant Feedback Rapid Prototyping for GPU-Accelerated Computation, Manipulation, and Visualization of Multidimensional Data Show publication in PURE
Christoph Wilhelm Sensen Plasticity of a holobiont: desiccation induces fasting-like metabolism within the lichen microbiota Show publication in PURE
Influence of domestic and environmental weathering in the self-cleaning performance and durability of TiO2 photocatalytic coatings Show publication in PURE
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome Show publication in PURE
Gerhard Thallinger Cytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival Show publication in PURE
Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders Show publication in PURE
Gerhard Thallinger Phylogenomics uncovers early hybridization and adaptive loci shaping the radiation of Lake Tanganyika cichlid fishes Show publication in PURE
Gerhard Thallinger The mitochondrial genome of the oribatid mite Paraleius leontonychus Show publication in PURE
Gerhard Thallinger Comparison of tear proteome in allergic rhinoconjunctivitis patients and controls with respect to pollen season Show publication in PURE
Gerhard Thallinger Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells Show publication in PURE
2017
Gerhard Thallinger Utility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patientsUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patients219 Show publication in PURE
Christoph Wilhelm Sensen Four distinct types of E.C. 1.2.1.30 enzymes can catalyze the reduction of carboxylic acids to aldehydes Show publication in PURE
Lipidomics: Prospects from a technological perspective Show publication in PURE
Lipidomics by ultrahigh performance liquid chromatography-high resolution mass spectrometry and its application to complex biological samples Show publication in PURE
Christoph Wilhelm Sensen Unravelling the Bauplan of life: The DNA sequencing revolutionUnravelling the Bauplan of life: The DNA sequencing revolution218 Show publication in PURE
Gerhard Thallinger Deciphering lipid structures based on platform-independent decision rules Show publication in PURE
Determination of the Isotopic Enrichment of 13C- and 2H-Labeled Tracers of Glucose Using High-Resolution Mass Spectrometry Show publication in PURE
Proposal for a common nomenclature for fragment ions in mass spectra of lipids Show publication in PURE
Gerhard Thallinger Erratum Show publication in PURE
Gerhard Thallinger Critical Issues in Mycobiota Analysis Show publication in PURE
Gerhard Thallinger MetExtract II Show publication in PURE
Gerhard Thallinger The Human Gastric Microbiome Is Predicated upon Infection with Helicobacter pylori Show publication in PURE
Gerhard Thallinger NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes Show publication in PURE
2015
Christoph Wilhelm Sensen Exploring functional contexts of symbiotic sustain within lichen-associated bacteria by comparative omics Show publication in PURE

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Team Leader
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Christoph Wilhelm Sensen
Univ.-Prof. Dipl.-Biol. Dr.rer.nat.

Team Website
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For more information visit our team website CBT.