Christoph W. Sensen is mainly interested in research topics related to Genome Research and Bioinformatics. Having worked previously in Canada, his group has participated in many large-scale Genome Projects, including recently an Oil Sands Metagenomics Research Program and the PhytoMetaSyn Program, which is related to the study of the Expressed Genes in 75 higher plants.
The Computational Biotechnology group began work in Graz in September 2014. By the end of 2015, all of the Computer Equipment will have been relocated from Calgary, Canada to Graz. The hardware and software environment currently being configured will be one of the most powerful Bioinformatics facilities in Austria.
The Computational Biotechnology Group is conducting research, especially related to the identification of serum-based DNA markers for chronic diseases and the development of rapid and cost-effective screening systems for the presence of particular DNA Sequences in the environment, and is also providing services related to high-throughput Bioinformatics analyses.
DNA-based markers identified from Circulating Nucleic Acids (CNA)
When animals get infected with diseases like Bovine Spongiform Encephalopathy or Bovine Respiratory disease, they start to release exosomes which contain specific DNA molecules into the blood stream. This specific process already starts at early stages of the disease, which makes it a promising candidate for the detection of the disease before any clinical sign could be observed.
Currently, the diagnostics and monitoring of chronic and infectious diseases in animals and humans is mainly based on the identification of an infective agent. This approach is slowly changing towards the measurement of the reaction of the host to the disease challenge. A new approach is the identification of DNA markers in the serum of diseased production animals (as well as humans), which can be used for the early identification of disease states, ideally before clinical signs emerge.
This research project is focused on industrial biotechnology enabling (a) the diagnostic of diseases in mammalian systems and (b) developing DNA screening devices for the rapid monitoring of the presence of specific DNA sequences in liquids, especially blood serum, to be used in animal production processes.
Petra HeidingerHydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necatorShow publication in PURE
Gerhard ThallingerThe CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In VitroShow publication in PURE
Christoph Wilhelm SensenCellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianusShow publication in PURE
Gerhard ThallingerUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patientsShow publication in PURE
Gerhard ThallingerGene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studiesShow publication in PURE
Gerhard ThallingerComparison and evaluation of integrative methods for the analysis of multilevel omics dataShow publication in PURE
Gerhard ThallingerDimension Reduction for the Integrative Analysis of Multilevel Omics DataDimension Reduction for the Integrative Analysis of Multilevel Omics DataShow publication in PURE
Gerhard ThallingerMyristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cellsShow publication in PURE
Gerhard ThallingerMethanol independent induction in Pichia pastoris by simple derepressed overexpression of single transcription factorsShow publication in PURE
Gerhard ThallingerA concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methodsShow publication in PURE
Christoph Wilhelm SensenInstant Feedback Rapid Prototyping for GPU-Accelerated Computation, Manipulation, and Visualization of Multidimensional DataShow publication in PURE
Christoph Wilhelm SensenPlasticity of a holobiont: desiccation induces fasting-like metabolism within the lichen microbiotaShow publication in PURE
Influence of domestic and environmental weathering in the self-cleaning performance and durability of TiO2 photocatalytic coatingsShow publication in PURE
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcomeShow publication in PURE
Gerhard ThallingerCytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survivalShow publication in PURE
Gerhard ThallingerComparison of tear proteome in allergic rhinoconjunctivitis patients and controls with respect to pollen seasonShow publication in PURE
Gerhard ThallingerDeletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma CellsShow publication in PURE
Gerhard ThallingerUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patientsUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patients219Show publication in PURE
Christoph Wilhelm SensenFour distinct types of E.C. 184.108.40.206 enzymes can catalyze the reduction of carboxylic acids to aldehydesShow publication in PURE