Julia Feichtinger's research focus lies on the large-scale analyses of transcriptomics and (epi)genomics data, in particular relating to long non-coding RNAs.
Exploiting the large amount of available sequencing data enables us to construct a comprehensive picture of gene expression patterns across tissues, diseases and cell types and, therefore, will help us to better understand the underlying mechanisms of gene expression regulation and its dysregulation in diseases.
Advances in this field will greatly promote molecular biology and clinical/biomedical research. Furthermore, we support biologists with biostatistics and bioinformatics analyses.
FWF Project T 923-B26 - Antisense and Allele-specific Transcription in Human Cancer January 2018 - June 2021
We are investigating two widespread transcriptional phenomena, antisense and allele-specific transcription, in a large-scale study. Antisense transcripts are at least partially complementary to a corresponding (mainly protein-coding) sense transcript and can have diverse functional roles in gene regulation (e.g., modifying epigenetic marks). This genomic arrangement also clearly suggests that antisense transcripts are mainly involved in allele-specific gene regulation/silencing. We aim to construct a comprehensive picture of these processes in a large panel of cancer samples and healthy controls by making use of the current wealth of transcriptomics and (epi)genomics data provided in the constantly growing public repositories. This will not only lead to new insights into gene regulation and provide new diagnostic/prognostic marker and drug target candidates for clinical applications but could also change the paradigm on how we conduct gene expression analyses in the future.
Petra HeidingerHydrogen-driven cofactor regeneration for stereoselective whole-cell C=C bond reduction in Cupriavidus necatorShow publication in PURE
Gerhard ThallingerThe CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In VitroShow publication in PURE
Christoph Wilhelm SensenCellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianusShow publication in PURE
Gerhard ThallingerUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patientsShow publication in PURE
Gerhard ThallingerGene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studiesShow publication in PURE
Gerhard ThallingerComparison and evaluation of integrative methods for the analysis of multilevel omics dataShow publication in PURE
Gerhard ThallingerDimension Reduction for the Integrative Analysis of Multilevel Omics DataDimension Reduction for the Integrative Analysis of Multilevel Omics DataShow publication in PURE
Gerhard ThallingerMyristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cellsShow publication in PURE
Gerhard ThallingerMethanol independent induction in Pichia pastoris by simple derepressed overexpression of single transcription factorsShow publication in PURE
Gerhard ThallingerA concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methodsShow publication in PURE
Christoph Wilhelm SensenInstant Feedback Rapid Prototyping for GPU-Accelerated Computation, Manipulation, and Visualization of Multidimensional DataShow publication in PURE
Christoph Wilhelm SensenPlasticity of a holobiont: desiccation induces fasting-like metabolism within the lichen microbiotaShow publication in PURE
Influence of domestic and environmental weathering in the self-cleaning performance and durability of TiO2 photocatalytic coatingsShow publication in PURE
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcomeShow publication in PURE
Gerhard ThallingerCytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survivalShow publication in PURE
Gerhard ThallingerUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patientsUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patients219Show publication in PURE
Christoph Wilhelm SensenFour distinct types of E.C. 188.8.131.52 enzymes can catalyze the reduction of carboxylic acids to aldehydesShow publication in PURE