Damage-assessment of Intraocular Lenses by correlative microscopy

Master Thesis (NanoVISION)

Cataract is the most common cause of blindness. Thankfully, it can be treated by replacing the cloudy natural lens by an artificial Intraocular lens (IOL).This procedure, called cataract surgery, is one of the most common operation in modern medicine and is performed more than 30 million times a year. Unfortunately, in many cases a secondary opacification occurs after the surgery, which is usually removed by Nd:YAG-Laser-Capsulotomy. This procedure uses a laser to remove the cloudy tissue around the IOL; it is a quick and effective procedure. However, if the laser is poorly aligned, it can cause various degrees of damage to the IOL (see below). These damages can later on lead to an impairment of the patient’s vision.

Correlative assessment of laser shots in IOLs by (a) ESEM, (b) Raman microscopy, (c) light microscopy

The aim of this master thesis is to do a systematic analysis of the laser damages caused to different IOL-types and materials by the correlation of various microscopic techniques, such as environmental scanning electron microscope (ESEM), Raman microscopy or light microscopy. The thesis involves close cooperation with the ophthalmologists Borkenstein & Borkenstein and is embedded in the Nano-VISION project that aims at improving various aspects of the cataract surgery. By that, this thesis not only introduces the master student to a variety of analytic and microscopic techniques, but also to interdisciplinary research at the juncture of material science and medicine.

The ideal applicant has a strong interest in interdisciplinary and experimental work and will receive a financial support of € 2640,- (€ 440 for 6 months).

Addressed to Master students from the following fields of Technical Physics, Advanced Materials Science and Technical Chemistry.

Start: As soon as possible

Dipl.-Ing. Dr. Harald Fitzek
0316 873 8333
Institut für Elektronenmikroskopie und Nanoanalytik (FELMI) &
Zentrum für Elektronenmikroskopie (ZFE)
Steyrergasse 17
8010 Graz