Katharina Hiebler

Katharina Hiebler
BSc MSc
Phone
+43 (316) 873 - 30405
Office hours
nach Vereinbarung

About me

Born in Graz, I decided to stay in my hometown after leaving school and started the bachelor’s programme Environmental System Sciences with the special field chemistry at University of Graz. Early I began to recognize that my special interest is on chemistry and therefore I decided to continue with the master’s programme Chemistry. In my bachelor thesis as well my master thesis I worked on the topic of biocatalysis, which focuses on the application of enzymes for chemical transformations. After my graduation in 2016 I started the PhD programme Chemical Engineering at the Institute of Process and Particle Engineering at Graz University of Technology and since March 2017 I am part of the Horizon2020-project “One-Flow”.


Research interests

My research within the framework of the One-Flow project targets the continuous syntheses of the active pharmaceutical ingredients valsartan and sacubitril, which are applied in a combination drug for the treatment of hypertension and heart failure. Key step of the multistep syntheses is a Suzuki-Miyaura coupling facilitated by novel heterogeneous palladium catalysts. Additionally, the use of enzymes is planned to accomplish product formation and to implement a more sustainable reaction protocol.

Tools

Apart from classical organic synthesis as well as the synthesis of heterogeneous catalysts I work on the identification of components via nuclear magnetic resonance spectroscopy (NMR), high performance liquid chromatography (Agilent 1260 HPLC) and mass spectrometry (Alliance HPLC-MS Waters). Furthermore, I am using nitrogen physisorption (ASAP 2000), He-pycnometry (SYLAB Accupyc) and laser diffraction for particle analysis.

Publications

PURE